Christopher J . Destache, PharmD, FCCP, BCIDP

Department

Pharmacy Practice

Position

Professor

Books

• Foye's Principles of Medicinal Chemistry
  Destache C. Clinical Significance of Antiviral Agents. Foye’s Principles of Medicinal Chemistry. 8th ed. Wolters Kluwer Publishers. 2018. 2018
• Journal of Doctoral Nursing Practice
  Destache CJ. Brain as an HIV Sequestered Site: Use of Nanoparticles as a Therapeutic Option. Progress in Brain Research (Volume 180, Chapter 12). Elsevier Academic Press. 2010. 2010
• Journal of Doctoral Nursing Practice
  Gendelman HE, Destache CJ, Zelivyanskaya ML, et al. Neuroimaging and proteomic tracking of neurodegeneration in MPTP-treated mice. Parkinson’s Disease The Life Cycle of the Dopamine Neuron. Federoff HJ, Burke RE, Fahn S, Fiskum G. eds. Annuals of the New York Academy of Sciences. Vol 991 2002; pg 319-321. 2002
• Sunshine IC. ed.
  96 Normal 0 false false false EN-US JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-fareast-language:EN-US;} Destache CJ, Meyer SM, Bittner MJ, Hermann KG.  Impact of a Clinical Pharmacokinetic Service on Patients Treated with Aminoglycosides:  A Cost-Benefit Analysis.  Recent Developments in Therapeutic Drug Monitoring. , p. pg. 159-164

Articles

• Journal of Infectious Diseases
  Shiv Patel , Gia Thinh Truong, Ajay Rajan, Zachary Creech, Ryan Walters, Ian Ng, Christopher Destache , Renuga Vivekanandan , Maureen Tierney , Manasa Velagapudi Discharge Disposition and Clinical Outcomes of Patients Hospitalized with COVID-19 2023
• Wisconsin Medical Journal
  Azeem A, Noor D, Carrig MW, Krajicek B, Destache CJ, Velegapudi M. Incidence and prognosis of pneumothorax and pneumomediastinum in patients with COVID-19. Wisc Med J 2023
• Pankaj Bhattarai, Pooja Hegde, Wei Li, Pavan Kumar Prathipati, Casey M. Stevens, Lixinhao Yang, Hinman Zhou, Amit Pandya, Katie Cunningham, Jenny Grissom, Mariaelena Roman Sotelo, Melanie Sowards, Lilian Calisto, Christopher J. Destache, Sonia Rocha-Sanchez, James C. Gumbart, Helen I. Zgurskaya, Mary Jackson, and E. Jeffrey North* Structural Determinants of Indole-2-carboxamides: Identification of Lead Acetamides with Pan Antimycobacterial Activity 2022
• Reiche W, Abodunrin F, Destache C, Rangray R, Velagapudi M. Doxycycline Induced Pancreatitis: An Uncommon Complication of a Common Drug 2022
• Intractable & Rare Diseases Research
  Nguyen A, Cooper S, Aldamen A, Destache C, Velagapudi M Incidence and clinical outcomes of COVID-19 in patients with chronic Hepatitis C. Intractable & Rare Diseases Research. 2022
• Antimic Stew Health Epidem
  Cooper S, Destache CJ, Vivekanandan R. Improving understanding and utilization of the antibiogram among medical residents. Antimic Stew Health Epidem 2022;2,e142:1-3 2022
• Pharmacy
  Destache CJ, Ahmad F, Rajendrapasad S, Loranger A, Pruett W, Jagan N, Krajicek B, Schmidt D, Quimby D, Velagapudi M, Boldt D, Hayes S, Anthone J, Kessel B, Vivekanandan R. COVID-19 mortality and therapeutics. Pharmacy 2022;10:69. 2022
• Nanomaterials
  Mandal S,, Sunagawa S, Prathipati PK, Belshan M, Shibata A, Destache CJ. Preliminary efficacy of a human CCR5 antibody conjugated to a nanoparticle against HIV-1. Nanomaterials 2022;12:1942. 2022
• Journal of Infectious Diseases
  Jackson I, Jaradeh H, Aurit S, Aldamen A, Narechania S, Destache C, Velagapudi M. Role of procalcitonin as a predictor of clinical outcomes in patients with COVID-19. Int J Infect Dis 2022 2022
• Pharmacotherapy
  Destache CJ, Aurit S, Schmidt D, Peets Erkes L, Tierney M, Vivekanandan R. Bamlanivimab use in mild COVID-19 disease: A matched cohort design. Pharmacother 2021 July 30. https://doi.org/10.1002/phar.2613. 2021
• Clin Virol
  M Belshan, Belshan M, Raine MA, Cheng AV, Destache CJ, Goering RA, Siedlik JA, Stessman HA. SARS-CoV-2 variation in COVID-19 long-haulers. Clin Virol 2021 Submitted 2021
• Destache CJ, Ahmad F, Rajendrapasad S, Loranger A, Pruett W, Jagan N, Krajicek B, Schmidt D, Quimby D, Velagapudi M, Boldt D, Hayes S, Anthone J, Kessel B, Vivekanandan R. COVID-19 mortality and therapeutic agents. 2021 Submitted. 2021
• Journal of Medicinal Chemistry
  Hegde P, Li W, Pratipati PK, Pandya AN, Destache CJ Jackson M, North EJ. Design, synthesis and evaluation of bioisosteres of indole-2-carboxamides with pan antimycobacterial activity. J Med Chem 2021 Submitted 2021
• Antivir Res
  Mandal S, Sunagawa S, Prathipati PK, Belshan M, Shibata A, Destache CJ. Preliminary efficacy of a human CCR5 antibody conjugated to a nanoparticle against HIV-1. Antivir Res 2021 Submitted. 2021
• American Journal of Health-System Pharmacy
  Velagapudi M, Sanley MJ, Ased S, Destache CJ, Malesker MA. Pharmacotherapy of nontuberculous mycobacterial pulmonary disease. Am J Health Syst Pharm 2021 Accepted. 2021
• Infect Dis Rep
  Rajendrapasad S, Destache CJ, Quimby D. Mycobacterium avium complex genitourinary infections: Care report and literature review. Infect Dis Rep 2021;13(2):454-464. https://doi.org/10.3390/idr13020045.
  13, p. 454-464 2021
• Journal of HIV/AIDS & Infectious Diseases
  Rajendrapasad S, Cheriyan AT, Renna S Goodman MT, Destache CJ, Velagaputi M. Clinical features and outcomes of Covid-19 in PLWH: a single-center, age-matched cohort study of hospitalized and clinic patients. J HIV/AIDS & Infect Dis 2021;8:1-10.
  8, p. 1-10 2021
• Antimicrobial Agents and Chemotherapy
  Mandal S, Prathipati PK, Sunagawa SW, Destache CJ. Long-acting bictegravir/tenofovir alafenamide nanoformulation, a novel combination controlled release system to prevent HIV-1: A concept evaluation study. Antimicrob Agents Chemother 2021;65:e02320-20 https://doi.org/10.1128/AAC.02320-20. 2021
• Front Pharmacol
  Perazzolo S, Mandal S, Prathipati PK, Destache CJ. Bictegravir plus tenofovir alafenamide nanoformulation as a long-acting PrEP Regimen: Application of modeling to design non-human primate pharmacokinetic experiments. Front Pharmacol 2020 https://doi.ord/10.3389/fphar.2020.603242. 2020
• Nebraska Mortar & Pestle
  Tran L and Destache CJ. A New Fluoroquinolone Antibiotic: Delafloxacin (Baxdela) Nebraska Mortar & Pestle. 2020; https://www.npharm.org/mortarandpestle. 2020
• Pharmacy (MDPI)
  Anthone J, Boldt D, Alexander B, Carroll C, Ased S, Schmidt D, Vivekanandan R, Destache CJ. Implementation of a health-system wide antimicrobial stewardship program in Omaha, NE. Pharmacy 2019, 7,156; doi:10.3390/pharmacy7040156.
  7, p. 1-10 2019
• Diagnosis Microbiol Infectious Diseases
  Cavalieri SJ, Kwon S, Vivekanandan R, Ased S, Carroll C, Anthone J, Schmidt D, Baysden M, Destache CJ.  Effect of antimicrobial stewardship with rapid MALDI-TOF identification and Vitek 2 antimicrobial susceptibility testing on hospitalization outcome., p. doi: 10.1016/j.diagnmicrobio.2019.05.020. 2019
• Therapeutic Delivery
  Prathipati PK, Mandal S, Destache CJ.  A review of CCR5 antibodies against HIV: Current and future aspects.  Therap Del 2019;10(2), p. doi.org/10.4155/tde-2018-0072. 2019
• Destache CJ, Guervil DJ, Kaye KS.  Ceftaroline fosamil for the treatment of Gram-positive endocarditis: CAPTURE study experience.  Int J Antimicrob Agents 2019 , p. DOI: 10.1016/j.ijantimicrag.2019.01.014 2019
• Antiviral Research
  Mandal S, Prathipati PK, Belshan MA, Destache CJ. Potential long-acting bictegravir loaded nano-drug delivery system to prevent HIV-1 infection: A proof-of-concept study. , p. doi: 10.1016/j.antiviral.2019.04.007 2019
• Journal of Controlled Release
  Mandal S, Prathipati PK, Kang G, Zhao Y, Fan W, Li Q, Destache CJ. Nanoencapsulation introduces long-acting phenomenon to tenofovir alafenamide and emtricitabine drug combination: A comparative pre-exposure prophylaxis efficacy study against HIV-1 vaginal transmission., p. Dec 18;294:216-225 2018
• Biomedical Chromatography : BMC
  Prathipati PK, Mandal S, Destache CJ. Development ad validation of LC-MS/MS method for quantification of bictegravir in human plasma and its application to an intracellular uptake study., p. 2018 Sep 4:e4379. doi:10.1002/bmc.4379 2018
• Biomedical Chromatography : BMC
  Prathipati PK, Mandal S, Destache CJ.  LC-MS/MS method for the simultaneous determination tenofovir, emtricitabine, elvitegravir, rilpivirine analysis on dried blood spots., p. 2018;e4270. 2018
• Antiviral Research
  Mandal S, Kang G, Prathipati PK, Fan W, Li Q, Destache CJ. Long-acting parenteral antiretrovirals loaded into a nano-drug delivery system for HIV-1 treatment: Humanized mouse model study., p. 2018 Jun 6. pii: S0166-3542(18)30248-1. 2018
• Antimicrobial Agents and Chemotherapy
  Pandya A, Prathipati PK, Hegde P, Li W, Graham K, Mandal S, Drescher K, Destache C, Ordway D, Jackson M, North EJ.  Indole-2-carboxamides are Active Against an Acute Mycobacterium abscessus Infected Mouse Model. , p. DOI: 10.1128/AAC.02245-18. 2018
• Antivir Res
  Pattnaik A, Palermo N, Sahoo BR, Yuan Z, Hu D, Annamalai AS, Vu HLX, Correas I, Prathipati PK, Destache CJ, Li Q, Osorio FA, Pattnaik AK, Xiang S. Discovery of a non-nucleoside RNA polymerase inhibitor for blocking Zika virus replication through in silico screening., p. Doi: 10.1016/j.antiviral.2017.12.016. 2017
• Curr HIV Res 
  Holec A, Mandal S, Prathipati PK, Destache CJ. Nucleoside reverse transcriptase inhibitors: A thorough review, present status and future perspective as HIV therapeutics., p. DOI:10.2174/1570162XI5666171120110145​​​​​​​ 2017
• Pharm Res
  Prathipati PK, Mandal S, Pon G, Vivekanandan R, Destache CJ. Pharmacokinetic and tissue distribution profile of long-acting tenofovir alafenamide and elvitegravir loaded nanoparticles in humanized mice model. 2017; Sept 13;, p. doi: 10.1007/s11095-017-2255-7 2017
• Polymer 2017
  Mandal S, Khandalavala K, Pham R, Bruck P, Varghese M, Kochvar A, Monaco A, Prathipati P, Destache C, Shibata A. Cellulose acetate phthalate and antiretroviral nanoparticle fabrications for HIV pre-exposure prophylaxis., p. doi:10.3390/polym9090423. 2017
• J Nanotech Mater Sci 
  Khandalavala K, Mandal S, Pham R, Destache CJ, Shibata A. Nanoparticle encapsulation for antiretroviral pre-exposure prophylaxis., p. doi:10.15436/2377-1372.17.1583.​​​​​​ 2017
• Infect Contr Hosp Epi
  Ased S, Rayes H, Dhami J, Amosson N, Fordjour A, Macaraen J, Vivekanandan R, Wilson J, Cabri A, Davids M, Anthone J, Cavaleri SA, Destache CJ. Evaluation of Staphylococcus aureus Bacteremia: Academic and Community-based Management Within a Health System  , p. https://doi.org/10.1017/ice.2017.30​​​​​​​ 2017
• AIDS
  Mandal S, Prathipati PK, Kang G, Zhao Y, Zhe Y, Fan W, Li Q, Destache CJ. Tenofovir alafenamide and elvitegravir nanoparticles for long-acting prevention of HIV-1 vaginal transmission. , p. doi: 10.1097/QAD.0000000000001349. PMCID 5283613.​​​​​​ 2017
• Antimicrob Agents Chemother
  Mandal S, Belshan MB, Holec A, Zhou Y, Destache CJ.  An enhanced emtricitabine loaded long-acting nano-formulation for prevention or treatment of HIV infection , p. pii:10.1128/AAC.01475-16. https://doi.org/10.1128/aac.01475-16 PCMID 5192106. 2016
• J Pharm and Biomed Anal
  Prathipati PK, Mandal S, Destache CJ.  Simultaneous quantification of tenofovir, emtricitabine, rilpivirine, elvitegravir, and dolutegravir in mouse biological matrices by LC-MS/MS and its application to a pharmacokinetic study. , p. 129:473-81.  http://dx.doi.org/10.1016/j.jpba.2016.07.040  PMCID 5003708. 2016
• J Am Osteo Assoc.
  Foral P, Anthone J, Destache C, Vivekanandan R, Preheim L, Gorby G, Horne J, Dobronski L, Syed J, Mindru C, Ali M, Ali K, Neemann K, Bittner M.  Interprofessional team practice education and face-to-face communication techniques in antimicrobial stewardship programs at two academic medical centers., p. 116(9):588-93. doi: 10.7556/jaoa.2016.116. 2016
• iScience Notes
  Destache CJ.  HIV cure. , p. https://drive.google.com/file/d/0B6lNiNcuTVQbbE5Tc2dyYUJUcm8/view 2016
• J Pharm and Biomed Anal 2016
  Prathipati PK, Mandal S, Destache CJ.  Simultaneous quantification of tenofovir, emtricitabine, rilpivirine, elvitegravir, and dolutegravir in mouse biological matrices by LC-MS/MS and its application to a pharmacokinetic study. , p. 129:473-81.  http://dx.doi.org/10.1016/j.jpba.2016.07.040  PMCID 5003708​​​​​​​. 2016
• Antimicrob Agents Chemother
  Destache CJ, Mandal S, Date AA, Yuan Z, Kang G, Lu W, Shibata A, Bruck P, Zhao Y, Fletcher CV, Li Q.  Topical application of tenofovir DF nanoparticles prevents HIV-1 vaginal transmission in humanized-BLT mice., p. 60(6):3633-9. doi:10.1128/AAC.00450-16. PMCID 4879396. 2016
• Drug Discovery Today
  Date AD, Destache CJ.  Natural polyphenols: Potential in the prevention of sexually transmitted viral infections.  , p. pii: S1359-6446(15)00416-X. doi: 10.1016/j.drudis.2015.10.019. 2015
• International Journal of Stem Cells
  Ahmad I, Zhao X, Parameswaran S, Destache CJ, Rodriguez-Sierra J, Ahmad H, Sorrentino J, Balasubramanian S. Direct differentiation of adult ocular progenitors into striatal dopaminergic neurons. International J Stem Cells 2015;8 http://dx.doi.org/10.15283/ijsc.2015.8.1.1.
  2015;8 http://dx.doi.org/10.15283/ijsc.2015.8.1.1. 2015
• US Pharmacist
  Bossou AR, Castillo S, O’Brien KK, Opere CA, Destache CJ.  Preventive HIV vaccines: Progress and challenges. , p. 40(10):46-50. 2015
• International Journal of Stem Cells
  Ahmad, I., Zhao, X., Parameswaran, S., Destache, C. J., Rodriguez-Sierra, J., Thoreson, W. B., Ahmad, H., Sorrentino, J., Balasubramanian, S. Direct differentiation of adult ocular progenitors into striatal dopaminergic neurons
  8, p. 106-114 2015
• Biomedical Chromatography : BMC
  Date, A. A., Shibata, A., Bruck, P., Destache, C. J. Development and validation of a simple and isocratic reversed-phase HPLC method for the determination of rilpivirine from tablets, nanoparticles and HeLa cell lysates
  29, p. 709-715 2015
• Biomedical Chromatography : BMC
  Date, A. A., Shibata, A., Bruck, P., Destache, C. J. Development and validation of a simple and isocratic reversed-phase HPLC method for the determination of rilpivirine from tablets, nanoparticles and HeLa cell lysates
  29, p. 709-715 2015
• Journal of Biomedical Nanotechnology
  Date, Abhijit A., Shibata, Annemarie, McMullen, Emily, La Bruzzo, Krista, Bruck, Patrick, Belshan, Michael, Zhou, You, Destache, Christopher J. Thermosensitive Gel Containing Cellulose Acetate Phthalate-Efavirenz Combination Nanoparticles for Prevention of HIV-1 Infection
  11, p. 416-427 2015
• Drug Discovery Today
  Date AD, Destache CJ. Natural polyphenols: Potential in the prevention of sexually transmitted viral infections. Drug Discovery Today 2015 Submitted. 2015
• British Medical Journal of the Heart
  Narayanan MA, Haddad TM, Baskaran J, Reddy AK, Mansour G, Destache C, Mooss A, Wichman T, Morrow L, Suri R, Kalil AC, Vivekanandan R. Evidence of lower mortality in early surgical intervention for infective endocarditis: A meta-analysis. Br Med J Heart 2015 Submitted. 2015
• J AIDS
  Li Q, Tso FY, Kang G, Fan W, Lu W, Li Y, Yuan Z, Destache CJ, Wood C. Early antiretroviral therapy prevents the establishment of HIV-1 infection in humanized-BLT mice. JAIDS 2015;69:519-527.
  69, p. 519-527 2015
• Journal
  Date AA, Shibata A, McMullen E, La Bruzzo K, Bruck P, Belshan M, Zhao Y, Destache CJ. Thermosensitive gel containing cellulose acetate phthalate-efavirenz nanoparticles for prevention of HIV-1 infection. J Biomed Nanotech 2015;11:416-427.
  11, p. 416-427 2015
• PLoS Pathogen
  Kovarova M, Council OD, Date AA, Long J, Nochii T, Belshan M, Shibata A, Vincent H, Baker CE, Thayer WO, Kraus G, Lachaud-Durand S, Williams P, Destache CJ, Garcia JV. Nanoformulations of rilpivirine for topical pericoital and systemic coital-independent administration efficiently prevent HIV transmission. PLoS Pathogen 2015; DOI:10.1371/journal.ppat 1005075.
  DOI:10.1371/journal.ppat 1005075. 2015
• AIP Advances
  Mandal S, Zhou Y, Shibata A, Destache CJ. Confocal fluorescence microscopy: an ultra-sensitive tool used to evaluate intracellular antiretroviral nano-drug delivery in HeLa cells. AIP Advances. 2015;8 http://dx.doi.org/10.1063/1.4926584 PMCID:4499042
  http://dx.doi.org/10.1063/1.4926584 PMCID:4499042 2015
• Journal of American Pharmacists Association
  Au T, Destache CJ, Vivekanandan R. Hepatitis C: Looking toward interferon-sparing regimens. J Am Pharm Assoc 2015:e72-86. http://dx.doi.org/10.1331/JAPhA.2015.15508.
  2015:e72-86. http://dx.doi.org/10.1331/JAPhA.2015.15508. 2015
• Journal of Doctoral Nursing Practice
  Destache CJ, Mandal S, Kang G, Zhe Y, Li Q. Combination antiretroviral nanoparticles as a sustained treatment modality in humanized mice. (In Preparation). 2015
• Journal of Doctoral Nursing Practice
  Destache CJ, Mandal S, Date AA, Zhe Y, Kang G, Lu W, Shibata A, Bruck P, Zhao Y, Fletcher CV, Li Q. Topical application of tenofovir DF nanoparticles prevents HIV-1 vaginal transmission in humanized-BLT mice. (In Preparation). 2015
• Journal of Pharmacy Practice
  Destache, C. J. Aminoglycoside-induced nephrotoxicity--a focus on monitoring: a review of literature
  27, p. 562-566 2014
• Clinical Infectious Diseases
  Hermsen, Elizabeth D., McDaneld, Patrick M., Eiland, Edward H., Destache, Christopher J., Lusardi, Katherine, Estrada, Sandy J., Mercier, Renée-Claude, DePestel, Daryl D., Lamp, Kenneth C., Anderson, Evette, Chung, Thomas J., McKinnon, Peggy S. Breaking Down the Barriers: Challenges With Development and Implementation of an Industry-Sponsored Antimicrobial Stewardship Data Collection and Analysis Tool
  59, p. S179-S184 2014
• Clinical Infectious Diseases
  DePestel, Daryl D., Eiland, Edward H., Lusardi, Katherine, Destache, Christopher J., Mercier, Renée-Claude, McDaneld, Patrick M., Lamp, Kenneth C., Chung, Thomas J., Hermsen, Elizabeth D. Assessing Appropriateness of Antimicrobial Therapy: In the Eye of the Interpreter
  59, p. S154-S161 2014
• Pharmacotherapy
  Dull, Ryan B., Friedman, Stacey K., Risoldi, Zara M., Rice, Eric C., Starlin, Richard C., Destache, Christopher J. Antimicrobial Treatment of Asymptomatic Bacteriuria in Noncatheterized Adults: A Systematic Review
  34, p. 941-960 2014
• Clinical Infectious Diseases
  DePestel DD, Eiland E III, Lusardi K, Destache CJ, Claude-Mercier R, McDaneld, P Lamp KC, Chung TJ, Hermsen ED. Assessing appropriateness of antimicrobial therapy: In the eye of the interpreter. Clin Infect Dis 2014 2014;59(Suppl 3):S154-S161.
  59 (Suppl) 3), p. S154-S161 2014
• Clinical Infectious Diseases
  Hermsen ED, McDaneld P, Eiland E III, Destache CJ, Lusardi K, Estrada S, Mercier R-C, DePestel D Lamp K, Anderson E, Chung T, McKinnon P. Breaking down the barriers: challenges with development and implementation of an industry-sponsored antimicrobial stewardship data collection and analysis tool. Clin Infect Dis 2014 2014;59(Suppl 3): S179-S184.
  59 (Suppl 3), p. S179-S184 2014
• Biomedical Chromatography : BMC
  Date AA, Shibata A, Bruck P, Destache CJ. Development and validation of a simple isocratic reverse-phase HPLC method for the determination of rilpivirine from tablets, nanoparticles, and cell lysates. Biomed Chromatog 2014 DOI 10.1002/bmc.3346. 2014
• Journal of Pharmacy Practice
  Destache CJ. Aminoglycoside-induced nephrotoxicity – A focus on monitoring: A review of the literature. doi: 10/1177/0897190014546102 http://jpp.sagepub.com/cgi/reprint/27/6/562.pdf?ijkey=eF7FbvzIRHukQoO&keytype=finite 2014
• Pharmacotherapy
  Dull RB, Friedman SK, Risoldi AM, Destache CJ. A systemic review of antimicrobial use for asymptomatic bacteriuria in non-catheterized adults. Pharmacother 2014; doi: 10/1002/phar.1437. 2014
• Biomaterials
  Date, Abhijit A., Destache, Christopher J. A review of nanotechnological approaches for the prophylaxis of HIV/AIDS
  34, p. 6202-6228 2013
• AIDS Research in Human Retroviruses
  Shibata A, McMullen E, Pham A, Belshan MA, Sanford B, Zhao Y, Goede M, Date A, Destache CJ. Polymeric nanoparticles containing combination antiretroviral drugs for HIV-1 treatment. AIDS Res Hum Retroviruses 2013;29(5):746-754. PMC3636590
  29(5), p. 746-754 2013
• Infectious Disease in Clinical Practice
  Knaak E, Cavalieri SM, Elsasser GN, Gonitzke A, Preheim LC, Destache CJ. Does antibiotic de-escalation for nosocomial pneumonia impact intensive care unit length of stay? Inf Dis Clin Pract 2013;21:172-176.
  21, p. 172-176 2013
• Biomaterials
  Date A and Destache CJ. Potential of nanotechnology to improve prophylaxis for HIV/AIDS. Biomaterials 2013. http://dx.doi.org/10.1016/j.biomaterials.2013.05.012 PMC482205. 2013
• Pharmacotherapy
  Davis, Estella M., Stang, Jenna, Foral, Pamela A., Baker, Thomas M., Destache, Chris Factors associated with early readmission of cardiothoracic surgical patients
  32, p. E109-E109 2012
• Antiviral Research
  Date, Abhijit A., Shibata, Annemarie, Goede, Michael, Sanford, Bridget, Bruzzo, Krista L., Belshan, Michel, Destache, Christopher J. Development and evaluation of a thermosensitive vaginal gel containing raltegravir? +? efavirenz loaded nanoparticles for HIV prophylaxis
  96, p. 430-436 2012
• Antiviral Research
  Date AA, Shibata A, Goede M, Sanford B, La Bruzzo K, Belshan M, Destache CJ. Development and evaluation of a thermosensitive vaginal gel containing raltegravir + efavirenz loaded nanoparticles for HIV prophylaxis. Antiviral Res 2012;96(3):430-436. PMC3513487
  96(3), p. 430-436 2012
• Clinical Medicine Insights: Cardiology
  Teply R, Goodman M, Destache CJ. Lopinavir-ritonavir: A review for 2011. Clinical Medicine Insights 2011;3:93-102.
  3, p. 93-102 2011
• Journal of Antimicrobial Chemotherapy
  Destache, C. J., Belgum, T., Goede, M., Shibata, A., Belshan, M. A. Antiretroviral release from poly(DL-lactide-co-glycolide) nanoparticles in mice
  65, p. 2183-2187 2010
• Therapeutic Delivery
  Destache, C. J., Goede, M., Belgum, T. Antiretroviral nanoparticles: An extended drug delivery modality. Spotlight article
  1, p. 383-386 2010
• American Journal of Pharmaceutical Education
  Packard, Kathleen A., Lenz, Thomas L., Destache, Christopher J. Teaching Heart Failure Treatment Guidelines and Assessing Heart Failure Therapy
  74, p. 103-103 2010
• American Journal of Pharmaceutical Education
  Elsasser, Gary N., Kavan, Michael G., Westerman, Gary H., Destache, Christopher J., Sexson, Emily, Turner, Paul D. A Survey of Pharmacy Students' Experiences With Gambling
  74, p. 26-26 2010
• American Journal of Pharmaceutical Education
  Packard, K. A., Lenz, T. L., Destache, C. J. A tool to teach heart failure treatment guidelines and to assess heart failure therapy in a pharmacy cardiology rotation
  74, p. 1-7 2010
• Therapeutic Delivery
  Destache CJ, Goede M, Belgum T. Antiretroviral nanoparticles: An extended drug delivery modality. Spotlight article. Therapeutic Delivery. 2010;1:383-386.
  1, p. 383-386 2010
• Journal of Antimicrobial Chemotherapy
  Destache CJ, Goede M, Belgum T, Shibata A, Belshan MA. Pharmacokinetics of antiretroviral release from PLGA nanoparticles in mice. J Antimicrob Chemother 2010;65:2183-2187. PMC2941676
  65, p. 2183-2187 2010
• American Journal of Pharmaceutical Education
  Packard KA, Lenz TL, Destache CJ. Teaching heart failure treatment guidelines and assessing heart failure therapy. Am J Pharm Educ 2010;74:Article 103. PMC2933012
  74, p. Article 103 2010
• American Journal of Pharmaceutical Education
  Elsasser GN, Kavan M, Westerman GH, Destache CJ, Sexson E, Turner PD. Pharmacy student experiences with gambling. Am J Pharm Educ 2010;74:Article 18. PMC2856415
  74, p. Article 18 2010
• Methods and findings in experimental and clinical pharmacology
  Zhao M, Destache CJ, Zhan G, Liu H, Zhang Y, Govindarajan V, Opere CA.  Regulation of endogenous amino acid neurotransmitters by isoprostanes in mammalian retina, ex vivo.  , p. 30:615-26.​​​​​​​ 2009
• Neurochemical Research
  Zhao, Min, Destache, Christopher J., Ohia, Sunny E., Opere, Catherine A. Role of Prostanoid Production and Receptors in the Regulation of Retinal Endogenous Amino Acid Neurotransmitters by 8-Isoprostaglandin E-2, Ex Vivo
  34, p. 2170-2180 2009
• Hospital Pharmacy
  Nystrom, K. K., Foral, P. A., Christensen, C. M., Destache, C. J., Davis, Estella M. Rotation Students' Perceptions of Clinical Workload Documentation Using a Personal Digital Assistant
  44, p. 968 2009
• Diabetes Spectrum
  Stading, J. A., Hermann, J., Walters, R., Destache, C. J., Chock, A. Impact of pharmacist intervention on diabetes patients in an ambulatory setting.
  22, p. 241-246 2009
• Diabetes Spectrum
  Stading J, Herrmann J, Walters R, Destache C, Chock A.  The impact of pharmacist intervention on diabetes patients in an ambulatory setting.  , p. 22:241-246.​​​​​​​ 2009
• Diabetes Educator
  Davis, Estella M., Bebee, Anne, Crawford, LeaAnne, Destache, Chris Nurse Satisfaction Using Insulin Pens in Hospitalized Patients
  35, p. 799-809 2009
• Journal of Immunology
  Dou, H., Grotepas, C. B., McMillan, J. M., Destache, C. J., Chaubal, M., Werling, J., Kipp, J., Rabinow, B., Gendelman, H. E. Macrophage delivery of nanoformulated antiretroviral drug to the brain in a murine model of neuroAIDS
  183, p. 661-669 2009
• International Journal of Instructional Technology and Distance Learning
  Elsasser, G. N., Hoie, E. B., Destache, C., Monaghan, M. S. Availability of internet download lecture audio files on class attendance and examination performance
  6, p. Article 3 2009
• BMC infectious diseases
  Destache, C. J., Belgum, T., Christensen, K., Shibata, A., Sharma, A., Dash, A. Combination antiretroviral drugs in PLGA nanoparticle for HIV-1
  9, p. 198 2009
• American Journal of Pharmaceutical Education
  Skrabal, M. Z., Jones, R. M., Nemire, R. E., Boyle, C. J., Assemi, M., Kahaleh, A. A., Soltis, D. A., Allen, R. E., Hritcko, P. M., O'Sullivan, T. A., Destache, C. J. National survey of volunteer pharmacy preceptors
  72, p. 112 2008
• Hernia
  Turaga K, Wright A, Lee R, Dias WP, Destache C, Christian R, Fitzgibbons RJ Jr. A randomized trial of the peri-operative use of COX-2 inhibitors in Lichtenstein herniorrhaphy.  , p. 12:515-519.​​​​​​​ 2008
• American Journal of Health-System Pharmacy
  Davis, Estella M., Christensen, Carla M., Nystrom, Kelly K., Foral, Pamela A., Destache, Chris Patient satisfaction and costs associated with insulin administered by pen device or syringe during hospitalization
  65, p. 1347-1357 2008
• Pharmacotherapy
  Carter BL, Davis LE, Drew RH, et al.  The research agenda of the American College of Clinical Pharmacy.  , p. 27:312-324.​​​​​​​ 2007
• Virology
  Dou, H. Y., Morehead, J., Destache, C. J., Kingsley, J. D., Shlyakhtenko, L., Zhou, Y., Chaubal, M., Werling, J., Kipp, J., Rabinow, B. E., Gendelman, H. E. Laboratory investigations for the morphologic, pharmacokinetic, and anti-retroviral properties of indinavir nanoparticles in human nomocyte-derived macrophages
  358, p. 148-158 2007
• American Journal of Health-System Pharmacy
  Elsasser, G. N., Goodman, M. D., Destache, C. J., Frey, D. R., Hadi, Z. Preprinted Risk Assessment and Prophylaxis Order Form for Venous Thromboembolism
  64, p. 1294 2007
• Blood
  Dou, H., Destache, C. J., Morehead, J. R., Mosley, R. L., Boska, M. D., Kingsley, J., Gorantla, S., Poluektova, L., Nelson, J. A., Chaubal, M., Werling, J., Kipp, J., Rabinow, B. E., Gendelman, H. E. Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery
  108, p. 2827-2835 2006
• J Neuroimmun Pharmacol
  Kingsley JD, Dou H, Morehead J, Gorantla S, Rabinow B, Gendelman HE, Destache CJ.  Nanotechnology: A focus on nanoparticles as a drug delivery system.  , p. 1:340-350​​​​​​​ 2006
• J Leuko Biol
  Gorantla S, Dou H, Boska M, Destache CJ, Nelson J, Poluektova L, Rabinow B, Gendelman HE, Mosley RL.  Quantitative magnetic resonance and SPECT imaging for macrophage tissue migration and nanoformulated drug delivery.  , p. 80(5):1165-1174​​​​​​​ 2006
• American Journal of Pharmaceutical Education
  Elsasser, G. N., Hoie, E. B., Destache, C. J., Monagahan, M. S. Effect of Lecture Audio Files on Class Attendance and Examination Performance
  70, p. Article 65 2006
• Glia
  Enose, Y., Destache, C. J., Mack, A. L., Anderson, J. R., Ullrich, F., Ciborowski, P. S., Gendelman, H. E. Proteomic fingerprints distinguish microglia, bone marrow, and spleen macrophage populations
  51, p. 161-172 2005
• J Neurosci
  Boska MD, Lewis TB, Destache CJ, Benner EJ, Nelson J, Uberti M, Mosley RL, Gendelman HE.  Quantitative 1H magnetic resonance spectroscopic imaging determines therapeutic immunization in an animal model of Parkinson’s disease.  , p. 25(7):1691-1700​​​​​​​ 2005
• Proceedings of the National Academy of Sciences of the United States of America
  Benner, E. J., Mosley, R. L., Destache, C. J., Lewis, T. B., Jackson-Lewis, V., Gorantla, S., Nemachek, C., Green, S. R., Przedborski, S., Gendelman, H. E. Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease
  101, p. 9435-9440 2004
• J Neuroimmun Pharmacol
  Carlson KA, Ciborowski P, Schellpeper CN, Biskup TM, Shen R-F, Luo X, Destache CJ, Gendelman HE.  Proteomic fingerprinting of HIV-1-infected monocyte-derived macrophages:  A preliminary report.  , p. 147:35-42​​​​​​​ 2004
• Annuals of the New York Academy of Sciences
  Gendelman HE, Destache CJ, Zelivyanskaya ML, Nelson JA, Boska MD, Biskup TM, McCarthy MK, Carlson KA, Nemechek CR, Benner EJ, Mosley RL.  neuroimaging and proteomic tracking of neurodegeneration in MPTP-treated mice.  , p. 991:319-321​​​​​​​ 2003
• Parkinson's Disease: the Life Cycle of the Dopamine Neuron
  Gendelman, H. E., Destache, C. J., Zelivyanskaya, M. L., Nelson, J. A., Boska, M. D., Biskup, T. M., McCarthy, M. K., Carlson, K. A., Nemechek, C., Benner, E. J., Mosley, R. L. Neuroimaging and proteomic tracking of neurodegeneration in MPTP-Treated mice
  991, p. 319-321 2003
• Disease Management and Health Outcomes
  Chock, A., Gong, V., Destache, C. J. Antibacterials and acute exacerbation of chronic bronchitis - Issues for formulary decision makers
  10, p. 333-336 2002
• Pharmacotherapy
  Packard KA, Backes JM, Lenz TL, Wurderman RL, Destache CJ, Hilleman DE.  Comparison of gemfibrozil and fenofibrate in patients with dyslipidemic coronary heart disease.  , p. 22:1527-1532​​​​​​​ 2002
• Pharmacotherapy
  Destache, CJ Optimizing economic outcomes in acute exacerbations of chronic bronchitis
  22, p. 12S-17S 2002
• Pharmacotherapy
  Faulkner, M. A., Hilleman, D. E., Destache, C. J., Mooss, A. N. Potential influence of timing of low-density lipoprotein cholesterol evaluation in patients with acute coronary syndrome
  21, p. 1055-1060 2001
• J Antimicrob Chemother
  Destache CJ, Pakiz CB, Larsen C, Owens HM, Dash AK.  Penetration of Levofloxacin into the Cerebrospinal Fluid and its Pharmacokinetics in an Experimental Rabbit Meningitis Model., p. 47:611-615​​​​​​​ 2001
• Journal of Antimicrobial Chemotherapy
  Destache, C. J., Pakiz, C. B., Larsen, C., Owens, H., Dash, A. K. Cerebrospinal fluid penetration and pharmacokinetics of levofloxacin in an experimental rabbit meningitis model
  47, p. 611-615 2001
• Pharmacotherapy
  Streetman, D. S., Nafziger, A. N., Destache, C. J., Bertino, J. S. Individualized pharmacokinetic monitoring results in less aminoglycoside-associated nephrotoxicity and fewer associated costs
  21, p. 443-451 2001
• The Journal of Pediatric Pharmacology and Therapeutics
  Pong A, Harrison CJ, Seidel TW, Needelman HW, Jirka JH, Awad KA, Cothran DL, Ohri L, Destache CJ.  Pilot study using a nomogram to predict gentamicin dosing intervals in preterm neonates treated with high dose gentamicin.  , p. 6:392-400​​​​​​​ 2000
• Pharm Education (Chinese)
  Alsarif NZ, Destache CJ, Roche VF. Teaching Medicinal Chemistry to Meet Outcome Objectives for Pharmacy Students., p. 3 (Fall):50-53​​​​​​​ 2000
• Pharmacotherapy
  Kelly JJ, Destache CJ, Horowitz EA, Fruin AH, Long VA.  A Complicated Case of M. tuberculosis Meningitis: Diagnosis and Treatment. ;, p. 19:1167-1172​​​​​​​ 1999
• Am J Pharmaceutical Education
  Alsarif NZ, Destache CJ, Roche VF. Teaching Medicinal Chemistry to Meet Outcome Objectives for Pharmacy Students., p. 63 (Spring):34-40 1999
• J Antimicrob Chemother
  Destache CJ, Dewan N, O’Donohue, Jr. W, Campbell JC, Angellio VA.  Economic and Clinical Effects of Treating Acute Exacerbations of Chronic Bronchitis., p. 43(Suppl A):107-113 1999
• Pharmacotherapy
  Destache CJ, Pakiz CB, Dash AK, Larsen C.  Nitric Oxide Concentrations in S. pneumoniae Meningitis: Correlation to Cytopathology.  , p. 18:628-634 1998
• US Pharmacist
  Elsasser GN, Goodman M, Destache CJ.  Drug Interactions with Protease Inhibitors.   1998
• Pharmacotherapy
  Destache CJ, Pakiz CB, Kersting K.  Effect of Bovine Cerebrospinal Fluid on the Microbiological Killing of Azithromycin against N. meningitidis, S. pneumoniae, and H. influenzae., p. 17:989-992 1997
• US Pharmacist
  Sanders CC and Destache CJ.  b-Lactamase Resistance., p. July (Suppl):1-12 1996
• J Antimicrob Chemother
  Destache CJ, Pakiz CB, Stoysich AM.  A-80556 for S. pneumoniae Meningitis using Microdialysis:  Pharmacodynamics and Pharmacokinetics., p. 38:977-985 1996
• Medical Interface
  Destache CJ. Clinical and Economic Benefits of a Clinical Pharmacokinetic Service: 1987 Versus 1992 Data.  , p. 7(11):84-90. 1995
• Frontiers in Therapeutic Drug Monitoring and Clinical Toxicology
  Destache CJ. Pharmacoeconomics. Frontiers in Therapeutic Drug Monitoring and Clinical Toxicology  , p. (Suppl Issue) 28-30.​​​​​​​ 1993
• Ther Drug Monit
  Destache CJ.  The Use of Therapeutic Drug Monitoring in Pharmacoeconomics.  , p. 15:608-610 1993
• Pharmacoeconomics
  Destache CJ. Cost-Benefit Relationships in the Use of a Pharmacokinetic Service., p. 3:433-436. 1993
• Clin Pharmacokin
  Kosirog J, Rospond RM, Destache CJ, Hall PD. Aminoglycoside Forecasting in Neutropenic Patients with Cancer., p. 24:79-87. 1993
• Pharmacotherapy
  Massoomi F, Savage JL, Destache CJ.  Omeprazole - A Comprehensive Review., p. 13:46-59 1993
• J Clin Pharmacol
  Hilleman DE, Mohiuddin SM, Destache CJ, Stoysich AS, Nipper HC, Maleskar MA.  Impact of Food on the Bioavailability of Encainide. , p. 32:833-837 1992
• Ther Drug Monit
  Destache CJ, Hilleman DE, Mohiuddin SM, Lang PT.  Predictive Performance of Bayesian and Nonlinear Least Squared Regression for Lidocaine.  , p. 14:286-291. 1992
• DICP The Annuals of Pharmacother
  Hilleman DE, Mohiuddin SM, Mooss A, Hunter CB, Destache CJ, Sketch MH, Sr. Comparative Pharmacodynamic  of Intravenous Lidocaine in Acute and Chronic Ventricular Arrhythmias., p. 26:763-767​​​​​​​ 1992
• American Heart Journal
  Mohiuddin SM, Stoysich AS, Destache CJ, Gannon JM, Hilleman DE, Sketch MH., p. 123:729-732​​​​​​​ 1992
• Journal of Clinical Pharmacology
  Stoysich AS, Mohiuddin SM, Destache CJ, Nipper HC, Hilleman DE. Influence of Mexiletine on the Pharmacokinetics of Theophylline in Healthy Volunteers., p. 31:354-357​​​​​​​ 1991
• DICP The Annuals of Pharmacother
  Malesker MA, Mohiuddin SM, Destache CJ, Stoysich AS, Dean RR, Hilleman DE, Sketch MS.  Pharmacokinetic and Tolerance Evaluation of Actisomide, A New Antiarrhythmic Agent in Healthy Volunteers.  , p. 25:231-233.​​​​​​​ 1991
• Ther Drug Monit
  Destache CJ, Meyer SM, Rowley KA.  Does Accepting Pharmacokinetic Recommendations Impact Length of Hospitalization?  A Cost-Benefit Analysis.  , p. 12:427-433. 1990
• Ther Drug Monit
  Destache CJ, Meyer SM, Bittner MB, Hermann KG.  Impact of a Clinical Pharmacokinetic Service on Patients Treated with Aminoglycosides: A Cost-Benefit Analysis. , p. 12:419-426.​​​​​​​ 1990
• Clin Pharmacokin
  Bertino JM, Rodvold K, Destache CJ. Cost-Benefit of a Clinical Pharmacokinetic Service., p. 26:641-651 1990
• DICP The Annuals of Pharmacother
  Destache CJ, Meyer SM, Ortmeier BG, Padomek MT.  Impact of a Clinical Pharmacokinetic Service on Patients Treated with Aminoglycosides for Gram-Negative Infections.  , p. 23:33-37.​​​​​​​ 1989
• Drug Intell Clin Pharm.
  Hilleman DE, Mohiuddin SM, Patterson AJ, Ortmeier BG, Destache CJ.  Comparative Bioequivalence and Efficacy of Two Sustained-Release Procainamide Formulations in Patients with Cardiac Arrhythmias.  , p. 22:554-558.​​​​​​​ 1988
• Family Medicine
  Meyer SM, Destache CJ, Brittan J, Gurnee M, Barone EJ.  A Pharmacy Fellowship in a Family Practice Training Program.  , p. 18:394-396​​​​​​​ 1986
• Drug Intell Clin Pharm.
  Hilleman DE, Mohiuddin SM, Destache CJ.  Lidocaine-Induced Second Degree Mobitz Type II Heart Block:  A Case Report and a Review of the Literature.  , p. 19:669-673​​​​​​​ 1985
• Antimicrobial Stewardship & Healthcare Epidemiology
  Cooper S, Destache CJ, Vivekanandan R. Improving understanding and utilization of the antibiogram among medical residents 0022
• S Mandal, Mandal S, Prathipati PK, Destache CJ. BIC+TAF NP for HIV prevention. (In Preparation). -0001
• The Internet Medical Journal
  Ayca B, Izzettin FV, Pala O, Destache CJ, Stohs SJ, Uras F.  Comparison of Biochemical Parameters in Pediatric Patients with and without Urinary Tract Infection.  , p.  http://www.medjournal.com​​​​​​​
• nvited publication to Neurology Review Series
  Kelly JJ, Horowitz EA, Destache CJ, Fruin AH, Long VA.  Diagnosis and treatment of complicated tubercular meningitis.  I, p. 2:6-7,24​​​​​​​

Publications

• SCCM Annual meeting
  Swaney R., Destache C, Nguyen A, Kenny D, Jokomo-Nyakabau R, Millner P, Velagapudi M Utility of fungal biomarkers in critically ill patients with COVID-19 and fungal co-infection (#461). SCCM Annual Meeting 2023. 2023
• SCCM Annual meeting
  Macaraeg JC, Van Dyke ZM, Lee S, Malesker MA, Destache CJ, Highley AD Evaluation of IV Fentanyl infusion dose in the intensive care unit (#750). SCCM Annual Meeting 2023. 2023
• Chest
  Swaney R, Jokomo-Nuakabau R, Destache CJ, Velagapudi M. Incidence, clinical characteristics, and outcomes of COVID-19 patients with fungal co-infection. Platform presentation at Chest Annual meeting October 2022. 2022
• ATS Annual Meeting
  swaney R, Jackson I, Aurit, S, Destache C, Walters RW, Vivekanandan R, Narechania S, Velagapudi M. Clinical outcomes of patients hospitalized with COVID-19 pneumonia and treated with tocilizumab: A single center study (#5521). 2022 ATS Annual Meeting San Francisco, CA 2022
• IDWeek
  Cooper S, Vivekanandan R, Destache C Improving understanding and utilization of the antibiogram among medical residents. (#956) 2022 IDWeek. Washington, DC 2022
• Aldamen A, Pinjala A, Destache CJ, Velagapudi M. Incidence of COVID-19 in patients with chronic hepatitis C in an outpatient clinic. 2021 ACG Annual Meeting. Las Vegas, NV Oct 22-27, 2021. Submitted. 2021
• Cooper S, Destache CJ, Vivekanandan R. Project Gram. Improving the Understanding and Utilization of Antibiograms. 2021 IDWeek Late Breaker San Diego, CA. September 24-28, 2021. Submitted 2021
• Maxwell T, Orban, III J, Kufel W, Destache C, Williams K, Velagupudi M, Bookstaver B, Tatem L, McCracken J, Carpenter B, Sharma R. Outcomes of daptomycin dosing regimens in hemodialysis patients. 2021 IDWeek San Diego, CA. September 24-28, 2021. Accepted. 2021
• Creech ZA, Truong TGD, Vivekanandan R, Tierney M, Destache CJ, Velagapudi M. Discharge disposition of COVID-19 patients admitted to ICU. 2021 SCCM Annual Meeting, Las Vegas, NV. Submitted. 2021
• Chest
  Destache CJ, Aurit S, Jackson I, Velagaputi M, Narechania S. Procalcitonin as a predictor of clinical outcomes in COVID-19patients. 2021 CHEST Accepted. 2021
• Chest
  Dela Cruz J, Malesker M, Destache CJ, Shafer D, Plambeck R. Evaluation of thromboembolic events and anticoagulant strategies in coronavirus disease-2019 patients: A retrospective analysis. 2021 CHEST Accepted. 2021
• Mandal S, Prathipati PK, Destache CJ. A novel combination thermosensitive gel dressing for “prolonged field care (PFC)”. Rand Corp. March 9-12, 2020. 2020
• Ahmad F; Rajendraprasad S; Loranger A; Pruett W; KesselB; Jagan N; Boldt D; Schmidt D; Hayes S; Anthone J; Vivekanandan R; Quimby D; Velagapudi M; Krajicek B; Destache C. Influence of Health Disparities on COVID-19 Critical Care Admission. 2020 SCCM Annual Meeting. 2020
• Rajendraprasad S; Ahmad F; Loranger A; Pruett W; KesselB; Jagan N; Boldt D; Schmidt D; Hayes S; Anthone J; Vivekanandan R; Quimby D; Velagapudi M; Krajicek B; Destache C. COVID-19 Therapeutics: What Works? SCCM Annual Meeting 2020. 2020
• Reid E, Walters R, Destache CJ. Beta-lactam vs fluoroquinolone monotherapy for Pseudomonas aeruginosa infection: a systematic review and meta-analysis. 2020 IDWeek. Philadelphia, PA. 2020
• Sunagawa S, Mandal S, Prathipati PK, Destache CJ. CCR5 antibody targeted tenofovir alafenamide (TAF) and dolutegravir (DTG) loaded nanoparticles: dual protection for human immunodeficiency virus (HIV) functional cure. APhA Annual Meeting 2020. 2020
• Ased S, Horne JM, Vivekanandan R, Destache CJ. Antimicrobial stewardship (ASP) in rural and critical access hospitals (CAHs) using TeleStewardship services. (Abstract #2095) 2019 IDWeek Washington, DC Oct 2-6, 2019. 2019
• Boldt D, Anthone J, Alexander B, Ased S, Carroll C, Schmidt D, Destache CJ, Vivekanandan R. Implementation and results of a health-system antimicrobial stewardship (AMS) program. (#1069) 2019 IDWeek Washington, DC Oct 2-6, 2019. 2019
• Mandal S, Prathipati PK, Destache CJ. CCR5 targeted ARV loaded nanoparticle: Dual protection for HIV functional cure. (Abstract #2501) 2019 IDWeek Washington, DC Oct 2- 6, 2019. 2019
• Destache CJ, Detweiler B, Vivekanandan R. A longitudinal study of the effect of renal failure on readmission rates of patients with Clostridioides difficile. (Abstract #2394) 2019 IDWeek Washington, DC Oct 2-6, 2019. 2019
• Gummadi PP, Aurit S, Destache C, Walters R, George EK, Vivekanandan R, Velagapudi M. Comparison of incidence of Kaposi’s sarcoma amongst solid organ transplant recipients. (#2691) 2019 IDWeek Washington, DC Oct 2-6, 2019. 2019
• Ased S, Horne JM, Vivekanandan R, Destache CJ. Antimicrobial stewardship (ASP) in rural and critical access hospitals (CAHs) using TeleStewardship services. 2019 ACCP New York City, NY Oct 2019. 2019
• Cavalieri S, Kwon S, Carroll C, Ased S, Schmidt D, Vivekanandan R, Destache CJ. MatrixAssisted Laser Desorption/Ionization-Time of Flight (MALDI-TOF) and Vitek 2 along with Antimicrobial Stewardship (ASP) Result in Faster Antimicrobial Therapy for Infected Curriculum Vitae for Christopher J. Destache, Pharm. D., FCCP, BCIDP 21 Patients: The CHI Health Experience. 2018 IDWeek (Abstract #1808) San Francisco, CA. Oct 3-7, 2018. 2018
• Anthone J, Abbas A, Alexander B, Boldt D, Ased S, Carroll C, Cavalieri S, Horn J, Velagapudi M, Valenta C, Andukuri V, Paguia RS, Petzar M, Kassim TA, George EK, Magliulo EK, Destache CJ, Vivekanandan R. New Robust Antimicrobial Stewardship Program (ASP) Results in Reduction of Clostridium difficile 30-Day Readmission. 2018 IDWeek (Abstract #527) San Francisco, CA. Oct 3-7, 2018. 2018
• Abbas A, Aurit S, Destache CJ, Horne J, Gorby G, Vivekanandan R. Health Disparities in HIV and Pregnancy. 2018 IDWeek (Abstract #861) San Francisco, CA. Oct 3-7, 2018. 2018
• George E, Aurit S, Destache C, Vivekanandan R. Where you live matters: United States region as a significant predictor of mortality for ESBL infection based on a descriptive study using NIS database. 2018 IDWeek (Abstract #1195) San Francisco, CA. Oct 3-7, 2018. 2018
• Mandal S, Prathipati PK, Destache CJ. Pharmacokinetics of emtricitabine and elvitegravir (FTC+EVG) nanoparticles for PrEP (Abstract #553). 2018 ASM Microbe, Atlanta, GA June 8, 2018. 2018
• Dull R, Adie S, Ohri LK, Destache C, Qi Y. Use of an electronic medical record (EMR) system to assess clinical outcomes of laboratory-confirmed influenza (LCII) among adults across five health system hospitals (Poster #371900). Fall 2017 Clinical Vaccinology Course. National Foundation for Infectious Diseases (NFID). Bethesda, MD. November 3- 4, 2017 2017
• Foral P, Saunders J, Davis E, Packard K, Duggins K, Hrdy M, Horne J, Destache C. A multicenter evaluation of cardiovascular implantable electronic device (CIED) infection management. (Abstract 65313) IDWeek San Diego, CA. Oct 7-10, 2017. 2017
• Foral P, Dalke B, Brondum A, Horne J, Hrdy M, Destache CJ. A novel vancomycin standardized calculations method achieved therapeutic trough goals in obese and non-obese patients in a Veterans Affairs Health Care System. (Abstract 65274) IDWeek San Diego, CA. Oct 7-10, 2017 2017
• Mandal S and Destache CJ. Combination antiretroviral (cARV) loaded nanoparticles: A potential alternative future for HIV patients. World Conference on STDs, STIs & HIV/AIDS. Vancouver, BC. July 26-27, 2017. 2017
• Dull R, Adie S, Ohri LK, Destache C. Clinical outcomes of laboratory-confirmed influenza among hospital patients. (#4-101) ASHP Midyear Clinical Meeting. Dec 5, 2016 Las Vegas, NV. 2016
• Anthone J, Cabri A, Walters RW, Destache C, Vivekanandan R. Impact of Pharmacist-Led Education on Prescribing Habits for Acute Treatment of Suspected Sexually Transmitted Infections (STIs) in an Academic Medical Center Emergency Department (ED). IDWeek. New Orleans, LA Oct 26-30, 2016 2016
• Mandal S and Destache CJ. Nanodrug-delivery system: Helping drugs to reach their targeted disease destination. Drug Delivery & Therapy World Congress Boston, MA. Aug 22-25, 2016. 2016
• Mandal S, Destache CJ, Prathipati PK. Combination antiretroviral drug Loaded Nanoparticles: An efficacious nano-drug delivery system for prevention/treatment of HIV in a humanized (Hu-BLT) mouse model. Drug Delivery & Therapy World Congress Boston, MA. Aug 22-25, 2016. 2016
• Shibata A, Bruck P, Pham R, Mandal S, Destache C. Development of dolutegravir combination nanoparticle fabrications for HIV prophylaxis. 2016 ASM-Microbe Conference. Boston, MA Jun 16-20, 2016. 2016
• Dhami JK, Anantha Narayanan M, Quirk SK, Destache CJ, Vivekanandan R. Multidrugresistant Pseudomonas and continuous renal replacement therapy: A case report and review of Literature. (Abstract #10955) 2016 Am Thoracic Society annual meeting. San Francisco, CA May 18, 2016. 2016
• Journal of Doctoral Nursing Practice
  Hoie E, Le S, Destache C. Use of fluconazole as prophylaxis for invasive Candida infections in preterm infants: a retrospective chart review. 2015 Global Conference on Clinical Pharmacy. San Francisco, CA Oct 17-21, 2015. Accepted. 2015
• Journal of Doctoral Nursing Practice
  Narayanan MA, Mansour G, Haddad T, Destache C, Vivekanandan R. Is there enough evidence for early surgery in infective endocarditis? A meta-analysis. 2015 American Thoracic Society Annual Meeting, Denver, CO May 15-20, 2015. 2015
• Infectious Diseases
  Foral P, Anthone J, Horne J, Dobronski L, Syed J, Destache C, Vivekanandan R, Preheim L, Gorby G, Bittner M. Incorporating interprofessional practice education and motivational interviewing techniques in antimicrobial stewardship programs at two academic medical centers. (Abstract #P-428) 2015 IDWeek San Diego, CA. 2015
• Journal of Doctoral Nursing Practice
  Kaye KS, Destache C, Guevil DJ. Ceftaroline fosamil for the treatment of Gram-positive endocarditis CAPTURE study experience. 2015 Interscience Conference of Antimicrobial Agents and Chemotherapy. (Abstract #L-345) San Diego, CA. , p. Abstract #L-345 2015
• Journal of Doctoral Nursing Practice
  15. Davis EM, Stang J, Foral PA, Baker TM, Destache C. Factors associated with early readmission of cardiothoracic surgical patients. American College of Clinical Pharmacy. Abstract 26438. Virtual Poster Symposium ACCP May 22-24, 2012. 2015
• Journal of Doctoral Nursing Practice
  Li Q, Tso FY, Kang G, Lu W, Li Y, Fan W, Destache CJ, Wood C. Early antiretroviral therapy prevents the establishment of HIV-1 infection in humanized-BLT mice. (#396) 2014 Conference on Retroviruses and Opportunistic Infections. Boston, MA. Mar 3-6, 2014. Presented as a poster. 2014
• Journal of Doctoral Nursing Practice
  Date AA, Shibata A, Bruck P Rezich M, Madson C, Belshan M, Destache C. Polymeric nanoparticles of tenofovir disoproxil furmarate for HIV prophylaxis. (Abstract #T3100) 2014 American Association of Pharmaceutical Scientists Annual Meeting. San Diego, CA. Presented as a poster. 2014
• Journal of Doctoral Nursing Practice
  Destache CJ, Date AA, Zhe Y, Kang G, Lu W, Tso FY, Wood C, Li Q. Topical application of tenofovir DF nanoparticles prevents HIV-1 vaginal transmission in humanized-BLT mice. (Abstract #109) 2014 American College of Clinical Pharmacy Annual Meeting. San Antonio, TX. Presented as a poster., p. Abstract #109 2014
• Journal of Doctoral Nursing Practice
  Kaye K, Destache C, Cole P, Jandourek A, Friedland HD. Gram-positive infective endocarditis treated with ceftaroline fosamil: CAPTURE study experience. (Abstract #L-1735) 2014 Interscience Conference of Antimicrobial Agents and Chemotherapy. Washington DC. Presented as a poster. 2014
• Journal of Doctoral Nursing Practice
  Destache CJ, Date AA, Zhe Y, Kang G, Lu W, Tso FY, Wood C, Li Q. Topical application of tenofovir DF nanoparticles prevents HIV-1 vaginal transmission in humanized-BLT mice. (#H-997) 2014 Interscience Conference of Antimicrobial Agents and Chemotherapy. Washington DC. Presented as a poster. 2014
• Journal of Doctoral Nursing Practice
  Anthone J, Vivekanandan R, Mindru C, Ali K, Ali M, Horowitz E, Bittner M, Gorby G, Destache C, Preheim L. Impact of an antimicrobial stewardship program (ASP) on antimicrobial usage and incidence of Clostridium difficile infections (CDI) at an academic teaching hospital. Abstract 41546 IDWeek San Francisco, CA Oct 2-5, 2013. 2013
• Journal of Doctoral Nursing Practice
  J. Long, C. Destache, M. Swanson, A. Date, J.V. Garcia. Thermosensitive gel delivery of rilpivirine nanoparticles (RPV NPs) prevents vaginal HIV-1 acquisition. Abstract MOPE141 International AIDS Society Meeting, Kuala Lumpur, Malaysia, June 30-July 3, 2013. 2013
• Journal of Doctoral Nursing Practice
  Rajca A, Li Q, Belshan M, Date A, Destache C. Thermosensitive vaginal gel containing PLGA-NRTI conjugate nanoparticles for HIV prophylaxis. Abstract T5.862. 2013 Nanotech Conference. Washington DC. May 12-16, 2013. Presented as a poster.
  Vol. 46 2013
• Journal of Doctoral Nursing Practice
  13. Cernik B, Foral P, Hrdy M, Destache C. Evaluating the appropriateness of an antimicrobial intravenous to oral conversion protocol compared to antimicrobial stewardship recommendations in a veterans affairs health care system. International Pharmaceutical Abstracts 2012. ASHP Midyear Clinical Meeting 46 (Dec). P3-157
  46(Dec), p. P3-157 2012
• Journal of Doctoral Nursing Practice
  Date A, Shibata A, Goede M, Sanford B, DeBoer J, Belshan M, Destache CJ. Thermosensitive gel containing raltegravir + efavirenz loaded nanoparticles for HIV prophylaxis. Abstract 2737. 2012 American Association of Pharmaceutical Scientists Annual Meeting Chicago, IL. 2012
• Journal of Doctoral Nursing Practice
  17. Mohapatra S, Kadajji VG, Goede M, Destache CJ, Dash AK. Combination antiretroviral vaginal gels for prophylactic treatment of HIV-1. American Association of Pharmaceutical Scientists Annual Meeting, New Orleans, LA. November 2011. 2011
• Journal of Doctoral Nursing Practice
  Elsasser GN, Lorhan PS, Destache CJ. Identifying an optimal dose of vancomycin in morbidly obese patients. (Abstract 134). American College of Clinical Pharmacy Annual Meeting, Pittsburgh, PA October 2011. 2011
• Journal of Doctoral Nursing Practice
  18. Destache CJ, Knaak E, Elsasser GN, Cavalieri SM, Preheim LC. Antibiotic De-Escalation for ICU Pneumonia: What is the impact? (Abstract K-1454) 51st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL September 2011. 2011
• Journal of Doctoral Nursing Practice
  19. Destache CJ, Goede M, McMullen E, Pham A, Shibata A. Sub-cellular fractionation and confocal microscopy for nanoparticle antiretroviral drugs for HIV-infected cell lines. (Abstract 129) Protection from HIV: Targeted Intervention Strategies. A Keystone Conference. Whistler, British Columbia. Mar 20-25, 2011. Presented as a poster 2011
• Journal of Doctoral Nursing Practice
  Davis WM, Foral PA, Baker TM, Herdzina AM, Destache C, Hardy KM. Identification of factors associated with early readmission of cardiothoracic surgical patients in a community hospital. Abstract 32 American College of Clinical Pharmacy 31st Annual Meeting, Austin, TX October 17-21, 2010. 2010
• Journal of Doctoral Nursing Practice
  Packard KA, Lenz TL, Destache CJ. A tool to teach heart failure guidelines and assess therapy in a cardiology rotation. American Association of Colleges of Pharmacy Annual Meeting, Seattle, WA. July 11-12, 2010. 2010
• ECCMID
  Destache, C, Boldt D, Anthone J, Velagapudi M, Swaney R, Jerabek J, Malik N, Williams J, Jokomo-Nyakabau J, Vivekanandan R, Cavalieri S. Impact of centralized BACT/ALERT Virtuo blood culture system (VIRTUO) implementation on outcomes in patients with gram-negative bacteremia. (Abstract #1977) 33rd ECCMID. Copenhagen, Denmark. -0001

General

• Heart
  Narayanan MA, Haddad TM, Baskaran J, Reddy AK, Mansour G, Destache C, Mooss A, Wichman T, Morrow L, Suri R, Kalil AC, Vivekanandan R.  Evidence of lower mortality in early surgical intervention for infective endocarditis: A meta-analysis.   , p. pii: heartjnl-2015-308589. doi: 10.1136/heartjnl-2015-308589. [Epub ahead of print] 2016
• Annals of Pharmacotherapy
  Massoomi F, Mathews HG, Destache CJ. Effect of Seven Fluoroquinolones on the Determination of Creatinine by the Picric Acid and Enzymatic Methods., p. 27:586-588 1993

Presentations

• Evusheld for Pre-exposure COVDI-19 2023 ID symposium 2023
• HIV drugs. Family Medicine Grand Rounds 2022
• Oral Antivirals for COVID-19 2022 ID Symposium 2022
• A Little of This and Little of That: Finding COVID-19 Therapeutics. 2021 Infectious Diseases Symposium April 24, 2021 2021
• Expanded role of the pharmacist during the COVID-19 pandemic Presented with Dr. Malesker for Rho Chi Society annual summer seminar Zoom meeting June 19, 2020. 2020
• Augmented Renal Clearance: Peeing Antibiotics Fast. Midwest College of Clinical Pharmacy CE meeting. Omaha, NE. January 15, 2020 2020
• Available therapy for resistant Gram-negative bacilli: A changing picture. Presented at the 2019 Infectious Diseases Spring Symposium. CHI Health Creighton University Medical Center-Bergan Mercy April 27, 2019. 2019
• HIV PrEP. Presented at Multi-Cultural Health Science Student Association (MCHSS). Jan 15, 2019. 2019
• Antiretroviral nanoparticles: From PrEP to treatment to functional cure. Nebraska Center for Virology May 4, 2018. 2018
• HIV PrEP: Who, What, When, Why presented at the 2018 Infectious Diseases Symposium CHI Health Bergan Mercy Medical Center April 28. 2018. 2018
• Shipley S, Cavalieri S, Vivekanandan R, Destache CJ. Evaluation of the management of ESBL-producing Enterobacteriaceae infections: CHI Health Omaha. (Abstract 62548) IDWeek San Diego, CA. Oct 7-10, 2017. Presented as a poster. 2017
• Mandal S, Kang G, Prathipati P, Zhou Y, Yuan Z, Fan W, Li Q, Destache C. A comparison study of tenofovir alafenamide (TAF) plus emtricitabine (FTC) in solution and as nanoparticles (NPs) for pre-exposure prophylaxis (PrEP) in humanized BLT (hu-BLT) mice (Abstract WEPEA0194). 9th IAS Conference on HIV Science. Paris, Fr July 23-26, 2017. Presented as a poster. 2017
• Antimicrobial stewardship program. St. Francis Regional Medical Center. 2017
• Antimicrobial stewardship program. St. Francis Regional Medical Center. May 14, 2017 2017
• Antiretroviral nanoparticles for PrEP. NE Center for Virology Inter-Campus Annual Retreat 2017
• Antiretroviral nanoparticles for PrEP. NE Center for Virology Inter-Campus Annual Retreat March 20, 2017. 2017
• Ased S, Vivekanandan R, Anthone J, Rayes H, Dhami J, Cabri A, Davids M, Amosson T, Macaraeg J, Fordjour A, Wilson J, Cavalieri S, Destache C. A Comparison of Staphylococcus aureus Bacteremia (SAB) Diagnosis and Management: Differences Between Academic and Community Hospital Settings. (#1030) IDWeek. New Orleans, LA Oct 26-30, 2016. Presented as a poster. 2016
• "Antiretroviral Nanoparticles for HIV-1 Treatment and Prevention" Biomedical Sciences Department, Creighton University 2016
• "Exploring antiretroviral nanomedicines for treatment and prevention of HIV infection". Invited presentation Department of Pharmacy Sciences, School of Pharmacy, Creighton University. 2016
• Exploring antiretroviral nanomedicines for treatment and prevention of HIV infection. Invited presentation Tulane National Primate Research Center. 2016
• Exploring antiretroviral nanomedicines for treatment and prevention of HIV infection. Invited presentation Tulane National Primate Research Center. September 16, 2016. 2016
• Natural polyphenols: Use against viral STI. Northwest Regional Chemical Society, Anchorage, AK 2016
• Natural polyphenols: Use against viral STI. Northwest Regional Chemical Society, Anchorage, AK June 28, 2016. 2016
• Mandal S, Kang G, Yuan Z, Lu W, Prathipati PK, Li Q, Destache CJ. Combination antiretroviral (cARV) drug loaded nanoparticles (NPs) are efficacious in humanized (HuBLT) mice. (Abstract #SU-408) 2016 ASM-Microbe Conference. Boston, MA Jun 16-20, 2016. Presented as a poster. 2016
• New Antimicrobials. Creighton University Infectious Diseases Symposium. Omaha, NE 2016
• New Antimicrobials. Creighton University Infectious Diseases Symposium. Omaha, NE April 23, 2016. 2016
• Destache CJ, Mandal S, Prathipati PK. TDF/EVG nanoparticle formulation: plasma pharmacokinetics in humanized mice. (Abstract #16-1812) Conference on Retroviruses and Opportunistic Infections. Boston, MA Feb 22-25, 2016. Presented as a poster 2016
• Rapid Viral Respiratory Pathogen Identification. MEDS symposium. Omaha, NE 2014
• Antiretroviral nanoparticles for HIV infection. Presented at the 2014 ACCP Annual Meeting, Austin, TX October 14, 2014. 2014
• HIV Treatment Up-date and Treatment of Hepatitis C. Alaska Pharmacists Association annual meeting. 2014
• Topical tenofovir nanoparticle application prevents HIV-1 vaginal transmission in humanized-BLT mice. Nebraska Center for Virology Annual retreat, Nebraska City, NE 2014
• Evaluation of nanomedicine for HIV treatment and prevention. Distinguished Lecture Series. Texas Tech Center of Excellence in Infectious Diseases, Texas Tech University Health Sciences Center, El Paso, TX 2014
• Cerebrospinal fluid penetration and pharmacokinetics of anti-infective agents. Presented at the 2013 AAPS Annual Meeting and Exposition, San Antonio, TX 2013
• Development of a nanoparticle-based thermosensitive vaginal gel for HIV prevention. 47th American Chemical Society Regional Meeting. Omaha, NE 2012
• In vivo levels of ritonavir, lopinavir, efavirenz over time after intraperitoneal injection of antiretroviral PLGA nanoparticle. Part of the Great 8 abstracts presented at the 30th American College of Clinical Pharmacy meeting. Anaheim, CA 2009
• Assessing Current Threats: Natural and Man-Made. 38th Midyear Clinical Meeting of the American Society for Health-System Pharmacists. New Orleans, LA. 2003
• Statistics in Review. 10th Annual Pediatric Pharmacy Advisory Group Meeting. St. Louis, MO 2001
• Statistics in Review. 10th Annual Pediatric Pharmacy Advisory Group Meeting. St. Louis, MO 2001
• Optimizing Economic Outcomes in Respiratory Tract Infections. Satellite Symposium to the American College of Clinical Pharmacy annual meeting, Los Angeles, CA 2000
• Nitric Oxide Concentrations in S. pneumoniae Meningitis: Correlation to Cytopathology. Presented at the Society of Infectious Diseases Pharmacists Annual Meeting Toronto, Canada 1997
• Economic Evaluation of Clinical Pharmacy Services. Presented at the 1996 American Society of Health System Pharmacists Annual Meeting, San Diego, CA. 1996
• Economic Evaluation of Clinical Pharmacy Services. Presented at the 1995 American Society of Health System Pharmacists Midyear Clinical Meeting, Las Vegas, NV. 1995
• Moderator for Specialty Practice Group in Clinical Pharmacokinetics at the 1993 Midyear Clinical Meeting of the American Society of Hospital Pharmacists, Atlanta, GA. Topic: "Reimbursement Issues for Clinical Pharmacokinetics." 1993
• Does Accepting Pharmacokinetic Recommendations Impact Hospitalization? A Cost-Benefit Analysis. Platform presentation at the American Society of Hospital Pharmacists 24th Midyear Clinical Meeting, Atlanta, GA. 1989
• "Clinical Pharmacokinetics" at the Career Consultation Section of the 24th American Society of Hospital Pharmacists Midyear Clinical Meeting, Atlanta, GA. 1989
• Impact of a Clinical Pharmacokinetic Service on Patients Treated with Aminoglycosides: A Cost-Benefit Analysis. Platform presentation at the 10th Annual American College of Clinical Pharmacy Meeting, Kansas City, MO. 1989
• Inpatient Temperature Monitoring during the Transition of IV to Oral Antibiotics in the Treatment of Pyelonephritis: Is it necessary? Platform presentation at North American Primary Care Research Group Meeting, Seattle, WA. 1985

Other

• Impact of Clinical Microbiology Laboratory Process Optimization on Patient Outcomes with Bloodstream Infections

• Infectious Disease Department PCN Skin Testing

• Infectious Disease Department PCN Skin Testing

Awards

• Department of Medicine Best Fellow Research Award
  2019 Creighton University School of Medicine, Department of Medicine Best Fellow Research Award
  Creighton University School of Medicine
• Scholarly Achievement Award
  Creighton University School of Pharmacy & Allied Health Professions
• Scholarly Achievement Award
  Creighton University School of Pharmacy & Allied Health Professions