Patrick C . Swanson, PhD

Department

Med. Microbiology & Immunology

Position

Professor

Books

• Reference Module in Biomedical Research
  Swanson Patrick C., V(D)J Recombination, Somatic Hypermutation, and Class Switch Recombination [Book Chapter] 2014
• V(D)J Recombination
  Swanson Patrick C., Early steps of V(D)J rearrangement [Book Chapter] 2009

Articles

• Swanson Patrick C., Erratum 2003

Publications

• Nature communications
  Deng Silu, Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses
  14:1, p. 1456 - 17 2023
• Cell Reports
  Worth Alexandra N., Receptor editing constrains development of phosphatidyl choline-specific B cells in VH12-transgenic mice
  39:11 2022
• PloS one
  Schabla N. Max, The CRL4VPRBP(DCAF1) E3 ubiquitin ligase directs constitutive RAG1 degradation in a non-lymphoid cell line
  16:10 October 2021
• Journal of molecular cell biology
  Schabla N. Max, DCAF1 (VprBP)
  11:9, p. 725 - 735 2019
• Cellular Immunology
  Palmer Victoria L., IL10 restrains autoreactive B cells in transgenic mice expressing inactive RAG1
  331, p. 110 - 120 2018
• Journal of Immunology
  Max Schabla N., VprBP (DCAF1) regulates RAG1 expression independently of dicer by mediating RAG1 degradation
  201:3, p. 930 - 939 2018
• Gao Q., Driver Fusions and Their Implications in the Development and Treatment of Human Cancers
  23:1, p. 227 - 238.e3 2018
• FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  Ma Shibin, A long non-coding RNA, lincRNA-Tnfaip3, acts as a co-regulator of NF-B to modulate inflammatory gene transcription
  31:3, p. 1215 - 1225 2017
• Cell Reports
  Haney Staci L., Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a
  15:6, p. 1190 - 1201 2016
• Experimental Hematology
  Shukla A., Absence of Caveolin-1 Leads to Delayed Development of Chronic Lymphocytic Leukemia in Emu-TCL1 Mouse Model
  44:1, p. 30 - 37.e1 2016
• BMC Immunology
  Palmer Victoria L., Cd1d regulates B cell development but not B cell accumulation and IL10 production in mice with pathologic CD5(+) B cell expansion
  16:66, p. (12 pages) 2015
• Journal of Immunology
  Palmer Victoria L., VprBP is required for efficient editing and selection of Igκ+ B cells, but is dispensable for Igλ+ and marginal zone B cell maturation and selection
  195:4, p. 1524 - 1537 2015
• Antioxidants and Redox Signaling
  Manning Jared, Vitamin C promotes maturation of T-cells
  19:17, p. 2054 - 2067 2013
• BMC Molecular Biology
  Nakagawa Tadashi, VprBP (DCAF1)
  14 2013
• Blood
  Nganga Vincent K., Accelerated progression of chronic lymphocytic leukemia in Eµ-TCL1 mice expressing catalytically inactive RAG1
  121:19, p. 3855 - 3866 2013
• Nucleic Acids Research
  Wang Guannan, Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex
  40:13, p. 6082 - 6096 2012
• Molecular and Cellular Biology
  Shimazaki Noriko, Mechanistic basis for RAG discrimination between recombination
  32:2, p. 365 - 375 2012
• Journal of Proteome Research
  Ma Danjun, Smoke-Induced Signal Molecules in Bone Marrow Cells from Altered Low-Density Lipoprotein Receptor-Related Protein 5 Mice
  11:7, p. 3548 - 3560 2012
• The Journal of immunology (1950)
  Bai Jirong, Molecular regulation of BCL2 to IGH translocation in follicular lymphoma (165.38)
  186:1_Supplement, p. 165 - 165.38 2011
• The Journal of immunology (1950)
  Xie Wanqin, The V(D)J recombination machinery is organized as large complexes anchored on the nuclear matrix (62.1)
  186:1_Supplement, p. 62 - 62.1 2011
• PLoS One
  Palmer V. L., N-Acetylcysteine Increases the Frequency of Bone Marrow Pro-B/Pre-B Cells, but Does Not Reverse Cigarette Smoking-Induced Loss of This Subset
  6:9, p. e24804 2011
• Immunology
  Hassaballa A. E., Accumulation of B1-like B cells in transgenic mice over-expressing catalytically inactive RAG1 in the periphery
  134:4, p. 469 - 486 2011
• EMBO Journal
  Kassmeier Michele D., VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity
  31:4, p. 945 - 958 2011
• Annual Review of Genetics
  Schatz David G., V(D)J recombination
  45, p. 167 - 202 2011
• Inhalation Toxicology
  Fusby J. S., Cigarette smoke-induced effects on bone marrow B-cell subsets and CD4(+):CD8(+) T-cell ratios are reversed by smoking cessation: Influence of bone mass on immune cell response to and recovery from smoke exposure
  22:9, p. 785 - 796 2010
• The Journal of immunology (1950)
  Lange Miles, The V(D)J recombination machinery is associated with the nuclear matrix (88.3)
  184:1_Supplement, p. 88 - 88.3 2010
• The Journal of immunology (1950)
  Swanson Patrick, Smoking cessation reverses cigarette smoke-induced impairment of B cell development and skewed CD4:CD8 T cell ratios in mice (36.43)
  184:1_Supplement, p. 36 - 36.43 2010
• Journal of Biological Chemistry
  Shlyakhtenko Luda S., Molecular mechanism underlying RAG1/RAG2 synaptic complex formation
  284:31, p. 20956 - 20965 2009
• Nucleic Acids Research
  Kumar Sushil, Full-length RAG1 promotes contact with coding and intersignal sequences in RAG protein complexes bound to recombination signals paired in cis
  37:7, p. 2211 - 2226 2009
• BMC Molecular Biology
  Zhang Ming, HMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex
  10:1, p. 24 2009
• Molecular Cell
  Lu Haihui, A Biochemically Defined System for Coding Joint Formation in V(D)J Recombination
  31:4, p. 485 - 497 2008
• BMC Molecular Biology
  Kriatchko Aleksei N., HMG-box domain stimulation of RAG1
  9, p. 32 - 32 2008
• Journal of Biological Chemistry
  Swanson Patrick C., V(D)J Recombinase Binding and Cleavage of Cryptic Recombination Signal Sequences Identified from Lymphoid Malignancies
  283:11, p. 6717 - 6727 2008
• Nucleic Acids Research
  Raval Prafulla, Evidence for Ku70/Ku80 association with full-length RAG1, p. 2060 - 2072 2008
• Molecular and Cellular Biology
  Ciubotaru Mihai, Fluorescence resonance energy transfer analysis of recombination signal sequence configuration in the RAG1/2 synaptic complex
  27:13, p. 4745 - 4758 2007
• DNA Repair
  Raghavan Sathees C., The structure-specific nicking of small heteroduplexes by the RAG complex
  6:6, p. 751 - 759 2007
• The Journal of immunology (1950)
  Zhang Ming, Recognition and cleavage of cryptic recombination signal sequences identified from lymphoid malignancies (49.20)
  178:1_Supplement, p. S86 - S87 2007
• The Journal of immunology (1950)
  Swanson Patrick C., Immunodeficiency and accumulation of B1-like B cells in transgenic mice overexpressing catalytically inactive RAG1 (B2)
  178:1_Supplement, p. LB1 - LB1 2007
• Molecular and Cellular Biology
  Kriatchko Aleksei N., Identification and characterization of a gain-of-function RAG-1 mutant
  26:12, p. 4712 - 4728 2006
• Journal of allergy and clinical immunology
  Parks K.W., Transgenic Mice Expressing Catalytically Inactive RAG-1 Exhibit Hypogammaglobulinemia and Altered B Cell Development, but not Autoreactivity
  117:2, p. S100 - S100 2006
• Methods in Enzymology
  Bergeron Serge, RAG and HMGB1 Proteins
  408, p. 511 - 528 2006
• Journal of Biological Chemistry
  Bergeron Serge, Both high mobility group (HMG)-boxes and the acidic tail of HMGB1 regulate recombination-activating gene (RAG)-mediated recombination signal synapsis and cleavage in vitro
  280:35, p. 31314 - 31324 2005
• Molecular and Cellular Biology
  Raghavan Sathees C., Double-strand break formation by the RAG complex at the Bcl-2 major breakpoint region and at other non-B DNA structures in vitro
  25:14, p. 5904 - 5919 2005
• Immunological Reviews
  Swanson Patrick C., The bounty of RAGs: recombination signal complexes and reaction outcomes
  200, p. 90 - 114 2004
• Nature
  Raghavan Sathees C., A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex
  428:6978, p. 88 - 93 2004
• Journal of Biological Chemistry
  Swanson Patrick C., Full-length RAG-2, and Not Full-length RAG-1, Specifically Suppresses RAG-mediated Transposition but Not Hybrid Joint Formation or Disintegration
  279:6, p. 4034 - 4044 2004
• Molecular and Cellular Biology
  Swanson Patrick C., A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals (vol 22, pg 7790, 2002) Erratum
  23:8, p. 3029 - 3029 2003
• Molecular and Cellular Biology
  Swanson Patrick C., A RAG-1/RAG/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals
  22:22, p. 7790 - 7801 2002
• Molecular and Cellular Biology
  Swanson Patrick C., Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals
  22:5, p. 1340 - 1351 2002
• Molecular and Cellular Biology
  Swanson P. C., The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination
  21:2, p. 449 - 458 2001
• Molecular and Cellular Biology
  Swanson Patrick C., RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex
  19:5, p. 3674 - 3683 1999
• Immunity
  Swanson Patrick C., V(D)J recombination signal recognition
  9:1, p. 115 - 125 1998
• Molecular and Cellular Biology
  Li Wenhui, RAG-1- and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution
  17:12, p. 6932 - 6939 1997
• Journal of the American Chemical Society
  Stevens Shawn Y., Non nucleic acid inhibitors of protein·DNA interactions identified through combinatorial chemistry
  118:43, p. 10650 - 10651 1996
• Journal of Clinical Investigation
  Swanson Patrick C., Ligand recognition by murine anti-DNA autoantibodies
  97:7, p. 1748 - 1760 1996
• Biochemistry
  Swanson Patrick C., Ligand recognition by anti-DNA autoantibodies. Affinity, specificity, and mode of binding
  35:5, p. 1624 - 1633 1996
• Journal of Immunological Methods
  Stevens Shawn Y., Application of the gel shift assay to study the affinity and specificity of anti-DNA autoantibodies
  177:1-2, p. 185 - 190 1994
• Tetrahedron Letters
  Goodwin Jay T., Synthesis of a disulfide cross-linked DNA triple helix
  35:26, p. 4527 - 4530 1994
• Journal of Immunology
  Swanson Patrick C., High resolution epitope mapping of an anti-DNA autoantibody using model DNA ligands
  152:5, p. 2601 - 2612 1994
• Bioorganic and Medicinal Chemistry Letters
  Swanson Patrick C., Chemical sequencing of disulfide-crosslinked oligodeoxyribonucleotides
  3:10, p. 2117 - 2118 1993
• Journal of the American Chemical Society
  Stevens Shawn Y., Evidence for Induced Fit in Antibody-DNA Complexes
  115:4, p. 1585 - 1586 1993

Presentations

• Invited Speaker, VA Friday Seminar Series, VprBP(DCAF1) regulates V(D)J recombination by mediating RAG1 degradation: implications to immune repertoire development and genome stability 2019
• Invited speaker, GCBA Seminar Series, UNMC. VprBP(DCAF1) regulates V(D)J recombination by mediating RAG1 degradation 2018
• Poster presentation: IL10 regulates in vivo antibody production and in vitro lipopolysaccharide-induced B cell responses in dnRAG1 mice Swanson PC, Palmer VL, Worth A, Scott R, and Perry GA Keystone Symposia "B cells: mechanisms of immunity and autoimmunity" Dresden Germany 2018
• Poster presentation: VprBP/DCAF1 regulates RAG1 expression independently of Dicer by promoting RAG1 degradation. Schabla NM, Palmer VL, Perry GA, and Swanson PC. Keystone Symposia "B cells: Mechanisms in Immunity and Autoimmunity" Dresden, Germany 2018
• Oral Presentation: VprBP/DCAF1 regulates V(D)J recombination by mediating RAG1 degradation 2018
• FASEB SRC "Molecular Mechanisms of Immune Cell Development and Function" Snowmass Village CO Short talk Title: VprBP/DCAF1 mediates post-transcriptional regulation of RAG1 independent of Dicer 2017
• Poster presentation. "IL10 regulates in vivo antibody production and in vitro lipopolysaccharide-induced B cell responses in dnRAG1 miceFASEB SRC "Molecular mechansism of immune cell development and function" Snowmass Village CO 2017
• Poster presentation: VprBP regulates RAG1 expression at the post-transcriptional level and independently of Dicer Schabla NM, Palmer VL, Perry GA, and Swanson PC FASEB SRC "Molecular mechansism of immune cell development and function" Snowmass Village CO 2017
• St. Albert's Day Poster Session, Creighton University. Poster Presentation. N. MAX SCHABLA, Greg A. Perry, James T. Fletcher, Patrick C. Swanson. "STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF VPRBP, A NOVEL RAG1-INTERACTING FACTOR" 2015
• Allergy and Immunology Grand Rounds. Creighton University Omaha NE. Oral Presentation. Immunoglobulins: from genetics to B cell biology. 2015
• 56th American Society for Hematology Annual Meeting and Exposition. San Francisco CA. Poster Presentation. Ashima Shukla, Christine E Cutucache, Karan Rai, Siddharth Rai, Rene Opavsky, Patrick Swanson, and Shantaram S Joshi. Absence of Caveloin-1 Leads to Delayed Development of Chronic Lymphocytic Leukemia in E-TCL1 Mouse Model 2014
• Great Plains Analytical Cytometry Association 7th Annual Conference. Creighton University Omaha NE. Oral Presentation. "Using Multicolor Flow Cytometry And Cell Sorting To Define A Role For VprBP In B Cell Development And V(D)J Recombination". 2014
• Cold Spring Harbor Laboratories 2014 Meeting on GENE EXPRESSION & SIGNALING IN THE IMMUNE SYSTEM. Poster Presentation. Victoria L. Palmer, Razia Aziz-Seible, Mary Rothermund, Greg A. Perry, Patrick C. Swanson. VprBP, an E3 ubiquitin ligase adaptor protein that associates with full-length RAG1, is required for efficient V(D)J rearrangement of distal VH and Vk gene segments and editing of Igκ chain, but not for development of Igλ+ B cells 2014
• GCBA Seminar Series, UNMC, Omaha NE. Oral Presentation. Monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: possible origin due to defects in B cell receptor editing? 2014
• Midwest Student Biomedical Research Forum, Omaha NE. Poster Presentation. Razia S. Aziz-Seible, Koushik Mondal, Vicky L. Palmer, Greg A. Perry and Patrick C. Swanson. Is Herc2 required for B cell development and V(D)J recombination? 2013
• School of Pharmacy Seminar Series, UNMC, Omaha NE. Oral Presentation "A RAG1-associating E3 ubiquitin ligase regulates B cell development and V(D)J recombination" 2012
• CUSOM Faculty Club Reception, Omaha NE. S Kumar and PC Swanson. Poster Presentation. "Evidence for long-range RAG1/2 interactions with coding sequences in discrete V(D)J initiation complexes assembled on coupled cleavage substrates" 2008
• 39th Annual Midwest Student Biomedical Research Forum, Omaha NE. AN Kriatchko, S Bergeron, and PC Swanson. Oral Presentation. "HMG-box domain stimulation of RAG1/2 cleavage activity is metal ion dependent" 2008
• 39th Annual Midwest Student Biomedical Research Forum, Omaha NE. M Zhang, S Bergeron and PC Swanson. Poster Presentation. "HMGB1 promotes structure-specific DNA cleavage by the RAG proteins via a nick-hairpin mechanism" 2008
• 39th Annual Midwest Student Biomedical Research Forum, Omaha NE. S Kumar and PC Swanson. Poster Presentation. "Identification of long range protein-DNA contacts in synaptic complexes involved in V(D)J recombination" 2008
• Keystone Synposium "DNA Replication and Recombination" Santa Fe, NM Oral Presentation "Evidence for long-range RAG1/2 interactions with coding sequences in discrete V(D)J initiation complexes assembled on coupled cleavage substrates" 2008
• Keystone Synposium "DNA Replication and Recombination" Santa Fe, NM. Poster Presentation. PC Swanson, M Zhang, and S Bergeron. "HMGB1 promotes structure-specific DNA cleavage by the RAG proteins via a nick-hairpin mechanism." 2008
• Keystone Synposium "DNA Replication and Recombination" Santa Fe, NM. Poster Presentation. S Kumar and PC Swanson "Evidence for long-range RAG1/2 interactions with coding sequences in discrete V(D)J initiation complexes assembled on coupled cleavage substrates" 2008
• Molecular and Cellular Biology REsearch Group Oral Presentation "Linking DNA breaks to DNA repair in V(D)J recombination" 2007
• CUSOM Innovation in Basic Science and Clinical Research, Joselyn Art Museum Omaha NE. P Raval, AN Kriatchko, and PC Swanson. Poster Presentation. "Evidence for Ku70/80 association with full-length RAG1" 2007
• CUSOM Innovation in Basic Science and Clinical Research, Joselyn Art Museum Omaha NE. SK Anderson, AE Hassaballa, K Parks, GA Perry and PC Swanson. Poster Presentation. "Immunodeficiency and accumulation of B1-like B cells in transgenic mice overexpressing catalytically inactive RAG1" 2007
• UNMC Department of Pathology/Microbiology and Center for Leukemia and Lymphoma Research. "Links between V(D)J recombination and lymphoid cell malignancy: mechanisms and models" 2007
• 94th Annual Meeting of the American Association of Immunologists. Miami, FL. PC Swanson, DK Anderson, AE Hassaballa, K Parks, and GA Perry. Poster Presentation. "Immunodeficiency and accumulation of B1-like B cells in transgenic mice overexpressing catalytically inactive RAG1" 2007
• 94th Annual Meeting of the American Association of Immunologists. Miami, FL. P Raval, S Kumar, AN Kriatchko, and PC Swanson. Poster Presentation. "Evidence for Ku70/Ku80 association with full-length RAG1" 2007
• 94th Annual Meeting of the American Association of Immunologists. Miami, FL. M Zhang and PC Swanson. Poster Presentation. "Recognition and cleavage of cryptic recombination signal sequences identified from lymphoid malignancies" 2007
• St. Albert's Day Poster Session, Creighton University. M Zhang and PC Swanson. Poster Presentation. "Recognition and cleavage of cryptic recombination signal sequences identified from lymphoid malignancies" 2007
• St. Albert's Day Poster Session, Creighton University. AN Kriatchko, DK Anderson, and PC Swanson. Poster Presentation. "Identification of a gain-of-function RAG1 mutant" 2007
• 3rd Annual Nebraska Research and Innovation Conference. Poster Presentation. PC Swanson and GA Perry. "The Creighton University Flow Cytometry Core Facility: Machines and methods for high speed cell analysis and cell sorting." Quest Center Omaha, NE 2007
• Oral Presentation "Molecular Science at Creighton University: A brief overview" Nebraska Biomedical Research Retreat, Quarry Oaks, NE 2006
• EPSCoR 2006 Expo, Lincoln, NE Business Display for Creighton University Flow Cytometry Core Facility Perry, GA and PC Swanson 2006
• ASM Conference "Mobile DNA" Banff, Alberta, Canada "Characterization of a Novel Gain-of-Function RAG-1 Mutant" 2006
• 37th Midwest Student Biomedical Research Forum, Omaha NE AE Hassaballa (graduate student) Oral Presentation "Characterization of transgenic mice expressing catalytically inactive recombination activating gene 1" 2006
• 37th Midwest Student Biomedical Research Forum, Omaha NE P Raval (postdoctoral fellow), S Kumar (postdoctoral fellow), and PC Swanson. Poster Presentation "Association of full-length RAG1 to Ku links the cleavage and joining phases of V(D)J recombination" 2006
• 37th Midwest Student Biomedical Research Forum, Omaha NE A Kriatchko (graduate student), DK Anderson, and PC Swanson Poster Presentation "Characterization of a novel gain-of-function RAG-1 mutant" 2006
• 37th Midwest Student Biomedical Research Forum, Omaha NE M Zhang (graduate student) and PC Swanson Poster Presentation "Recognition and cleavage of cryptic recombination signal sequences identified from lymphoid malignancies" 2006
• Creighton University Department of Medicine Research Conference Omaha, NE "Autoimmunity and Immunodeficiency: A New Model Provides Insights into the Role of RAG-1" 2005
• Department of Medical Microbiology and Immunology Special Seminar Perry GA, and PC Swanson "Multicolor Cell Analysis and Cell Sorting Arrives at Creighton University" 2005
• UNMC Department of Genetics, Cell Biology and Anatomy seminar series. Omaha, NE "B cell development in transgenic mice overexpressing catalytically inactive RAG-1: implications for receptor editing and B1 versus B2 cell fate determination" 2005
• Oral Presentation Immunology Interest Group, University of Nebraska Medical Center "B cell development in transgenic mice expressing catalytically inactive RAG-1" 2005
• Bergeron S, Madathipirambil T, and Swanson PC. "Dissecting the structure-function relationship of HMGB1 in the initiation of V(D)J recombination in vitro". Poster presentation. Keystone Symposia: B cell development, function, and disease. Steamboat Springs, CO 2005
• Hassaballa AE, Perry GA, Parks KW, Anderson D, and Swanson PC. "Accumulation of transitional B cells in transgenic mice expressing catalytically inactive RAG-1". Poster presentation. Keystone Symposia: B cell development, function, and disease. Steamboat Springs, CO 2005
• Kriatchko AN, and Swanson PC. "Identification of a gain-of-function RAG-1 mutant". Poster presentation. Keystone Symposia: B cell development, function, and disease. Steamboat Springs, CO 2005
• Oral Presentation Allergy Fellows Teaching Conference "Antibodies: structure, function, origins,and investigations therein" 2005
• Introductory remarks American Cancer Society Relay for Life, Midtown 2005
• Oral Presentation, Third Annual Microbiology Meeting, University of Nebraska, Lincoln "Recent Research on the V(D)J Recombinase" 2004
• INBRE program seminar, Creighton University, Omaha, Nebraska "Antibodies: structure, function and origins of diversity" 2004
• Hassaballa AE, Wang L, and Swanson PC. "Investigation of the dominant negative effect of catalytically deficient mutant RAG-1 in vivo. Poster presentation. Great Plains States Society for Molecular Biology and Genetics. Quest Center, Omaha, NE 2004
• Kriatchko, A and Swanson, PC. "Identification of a gain-of-function RAG-1 mutant" Poster presentation. Greaat Plains States Society for Molecular Biology and Genetics. Quest Center, Omaha, NE. 2004
• Bergeron, S and Swanson, PC. "Dissecting the stucture-function relationship of HMGB1 in the initiation of V(D)J recombination." Poster presentation. Great Plains States Society for Molecular Biology and Genetics. Quest Center, Omaha, NE. 2004
• Raval, P and Swanson, PC. "P125 copurifies with DNA-PK and shares an immunoreactive domain with Artemis." Poster presentation. Great Plains States Society for Molecular Biology and Genetics. Quest Center, Omaha, NE. 2004
• BRIN program seminar, Creighton University, Omaha, Nebraska "Antibodies: structure, function and origins of diversity" 2003
• Poster presentation, AAI Immunology 2003, Denver, Colorado "The 'dispensable' regions of RAG-1 and RAG-2 play separable roles in regulating V(D)J recombinase activity in vitro" 2003
• Oral presentation, AAI Immunology 2003, Denver, Colorado "The 'dispensable' regions of RAG-1 and RAG-2 play separable roles in regulating V(D)J recombinase activity in vitro" 2003
• Oral Presentation, Nebraska Wesleyan University, Lincoln, Nebraska "V(D)J recombination and the origins of immune repertoire diversity" 2003
• Oral Presentation, Nucleic Acids Interest Group, Mahoney State Park "A RAG1/RAG2 tetramer supports synapsis, cleavage, and transposition of V(D)J recombination signals" 2002
• Oral Presentation Immunology Interest Group University of Nebraska Medical Center Omaha, Nebraska "Characterization of RAG complexes supporting synapsis, cleavage, and transposition of V(D)J recombination signals" 2002
• Poster Presentation 18th UICC Internation Cancer Congress, Oslo, Norway "A molecular characterization of RAG-1/RAG-2 synaptic complexes involved in V(D)J recombination" 2002
• Third Annual Meeting: Great Plains States Society for Molecular Biology and Genetics;"12/23-Regulated Synapis,Cleavage, and Transposition of V (D)J Recombination Signals is Supported by a RAG-1/2 Tetramer Complex" Abstract and Poster Presentation 2002
• Keystone Symposium on Molecular Mechanisms of DNA Replication and Recombination, Snowbird,UT"Comparison of catalytic activity and protein-DNA contacts in discrete RAG-RSS complexes lacking or containing HMG-1 or HMG-2" Abstract and Poster presentation 2002
• AAAS Southwest and Rocky Mountain Division Meeting, Creighton University, "Assembly and Function of V (D)J Initiation Complexes" 2001
• Nucleic Acids Interest Group, Mahoney State Park "Assembly and function of V(D)J initiation complexes" Oral Presentation 2001
• American Cancer Society Relay for Life; Norfolk, Nebraska; Introductory remarks in opening ceremony on the importance of cancer research and brief description my ACS funded research 2001
• Great Plains States Society for Molecular Biology and Genetics "Incorporation of HMG-1 or HMG-2 into V(D)J recombination pre-initiation complexes assembled on 23-RSS substrates stabilizes protein-DNA contacts at the heptamer and correlates with enhanced DNA cleavage activity" Poster Presentation 2001
• AAAS SWARM Meeting "The V(D)J recombinase cleaves DNA in trans" Oral Presentation 2000
• Immunology Interest Group Meeting, UNMC "Roles of RAG-1 and RAG-2 in V(D)J recombination" Oral Presentation 2000
• Oklahoma Medical Research Foundation, Oklahoma City, OK "The roles of RAG-1 and RAG-2 in the recognition and cleavage of V(D)J recombination signals" Invited Presentation 2000
• Immunology 2000, Seattle, WA "The V(D)J recombinase cleaves DNA in trans" Poster and Oral Presentation 2000
• Carleton College, Northfield, MN "The assembly of the antigen receptor genes: how RAG-1 and RAG-2 initiate V(D)J recombination" Invited Presentation Poster and Oral Presentation 2000
• St. Olaf College, Northfield, MN "The assembly of the antigen receptor genes: how RAG-1 and RAG-2 initiate V(D)J recombination" Invited Presentation Poster and Oral Presentation 2000
• VA Hospital 1999
• Distinct Roles for RAG-1 and RAG-2 in V(D)J Recombination Signal Recognition and Initiation Complex Assembly Keystone Symposium on B Lymphocyte Biology and Disease February 1999 1999

Awards

• Intramural Research Award
  Golden Apple Award Nomination for Excellence in Teaching by M1 students
• Intramural Research Award
  Young Investigator Award Creighton University School of Medicine
• Intramural Research Award
  Albert Lehninger Research Prize, Young Investigators' Day, The Johns Hopkins University School of Medicine, April 1999