Peter Stephen Steyger, PhD

Department

Biomedical Sciences

Position

Professor

Books

• Borse Vikrant, Ototoxic Hearing Loss and Balance Disorders: Challenges and Treatment 2022
• Inflammatory Mechanisms in Mediating Hearing Loss
  Steyger Peter S., Inflammation potentiates cochlear uptake of ototoxins and drug-induced hearing loss [Book Chapter] 2018

Articles

• Steyger Peter S., Reader response 2020
• Steyger Peter, From Screen to Trial 2018
• Steyger Peter, Translating in vitro data into auditory protection 2014

Publications

• American journal of audiology
  Janky Kristen, Mechanisms and Impact of Aminoglycoside-Induced Vestibular Deficits, p. 1 - 15 2023
• Pharmaceuticals
  Dash Shreshtha, Local Delivery of Therapeutics to the Cochlea Using Nanoparticles and Other Biomaterials
  15:9 2022
• Clinical Pharmacology and Therapeutics
  McDermott John Henry, Clinical Pharmacogenetics Implementation Consortium Guideline for the Use of Aminoglycosides Based on MT-RNR1 Genotype
  111:2, p. 366 - 372 2022
• Journal of Neuroinflammation
  Mathy Nicholas W., A novel long intergenic non-coding RNA, Nostrill, regulates iNOS gene transcription and neurotoxicity in microglia
  18:1 2021
• Otolaryngologic Clinics of North America
  Steyger Peter S., Mechanisms of Ototoxicity and Otoprotection
  54:6, p. 1101 - 1115 2021
• Journal of cystic fibrosis
  Garinis A., 105: Ototoxicity management for patients with cystic fibrosis
  20, p. S53 2021
• Frontiers in Education
  Huyck Julia Jones, Supporting Equity and Inclusion of Deaf and Hard-of-Hearing Individuals in Professional Organizations
  6 2021
• American Journal of Audiology
  Steyger Peter S., Mechanisms of aminoglycoside-and cisplatin-induced ototoxicity
  30:3S, p. 887 - 900 2021
• American Journal of Audiology
  Garinis Angela C., Clinical considerations for routine auditory and vestibular monitoring in patients with cystic fibrosis
  30:3S, p. 800 - 809 2021
• Hearing Research
  Tian Cong, CACHD1-deficient mice exhibit hearing and balance deficits associated with a disruption of calcium homeostasis in the inner ear
  409 2021
• Frontiers in Neurology
  Coffin Allison B., Detecting Novel Ototoxins and Potentiation of Ototoxicity by Disease Settings
  12 2021
• Frontiers in Neuroscience
  Prayuenyong Pattarawadee, Preferential Cochleotoxicity of Cisplatin
  15 2021
• Cold Spring Harbor Perspectives in Medicine
  Kros Corné J., Aminoglycoside- and cisplatin-induced ototoxicity
  9:11 2019
• Science Advances
  Jiang Meiyan, Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss
  5:7 2019
• Hearing Journal
  Steyger Peter S., Genetic Contributions to Age-Related Hearing Loss
  72:5, p. 10 - 13 2019
• Science Translational Medicine
  Nyberg Sophie, Delivery of therapeutics to the inner ear
  11:482 2019
• PloS one
  Kachelmeier Allan, Simplified, automated methods for assessing pixel intensities of fluorescently-tagged drugs in cells
  13:11 2018
• International Journal of Audiology
  Garinis Angela C., Monitoring neonates for ototoxicity
  57:sup4, p. S41 - S48 2018
• Steyger Peter S., Editorial 2018
• Frontiers in Cellular Neuroscience
  Jiang Meiyan, Potential mechanisms underlying inflammation-enhanced aminoglycoside-induced cochleotoxicity
  11 2017
• Frontiers in Cellular Neuroscience
  Jiang Meiyan, Aminoglycoside-induced cochleotoxicity
  11 2017
• International Journal of Pediatric Otorhinolaryngology
  Garinis Angela C., Effect of gentamicin and levels of ambient sound on hearing screening outcomes in the neonatal intensive care unit
  97, p. 42 - 50 2017
• Adler Henry J., Community network for deaf scientists 2017
• Hearing Journal
  Steyger Peter S., Is Auditory Synaptopathy a Result of Drug-Induced Hearing Loss?
  70:4, p. 8 - 9 2017
• Toxicology Letters
  Karasawa Takatoshi, An integrated view of cisplatin-induced nephrotoxicity and ototoxicity
  237:3, p. 219 - 227 2015
• Expert Opinion on Therapeutic Patents
  Jiang Meiyan, An evaluation of US patent 2015065565 (A1) for a new class of SGLT2 inhibitors for treatment 1 of type II diabetes mellitus
  25:11, p. 1349 - 1352 2015
• Science Translational Medicine
  Koo Ja Won, Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity
  7:298 2015
• Hearing Journal
  Steyger Peter S., Novel Aminoglycoside Antibiotics Show Reduced Ototoxicity Risk
  68:4, p. 32 - 35 2015
• Hearing Journal
  Steyger Peter S., Hearing Loss Risk Factors for Cystic Fibrosis Patients
  69:4, p. 8 - 9 2015
• PloS one
  Yang Yuqin, Diverse Kir expression contributes to distinct bimodal distribution of resting potentials and vasotone responses of arterioles
  10:5 2015
• Frontiers in Cellular Neuroscience
  Li Hongzhe, Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells
  9:APR 2015
• PloS one
  Liu Jianping, Uptake of fluorescent gentamicin by peripheral vestibular cells after systemic administration
  10:3 2015
• International Journal of Pediatric Otorhinolaryngology
  Cross Campbell P., Effect of sepsis and systemic inflammatory response syndrome on neonatal hearing screening outcomes following gentamicin exposure
  79:11, p. 1915 - 1919 2015
• PloS one
  Jiang Meiyan, Sodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides
  9:9 2014
• Otolaryngology-head and neck surgery
  Luk Lauren J., Perilymphatic Gentamicin Trafficking through Basolateral Channels May Underlie Enhanced Ototoxicity by Noise-Induced Threshold Shifts
  151:1_suppl, p. P222 - P222 2014
• Otolaryngology-head and neck surgery
  Liao Selena, Noise Exposure in the Neonatal Intensive Care Unit: A Prospective Study
  149:2_suppl, p. P249 - P249 2013
• Otolaryngology-head and neck surgery
  Liao Selena, Differences in DPOAE and AABR in Noise-Exposed Infants in the Neonatal Intensive Care Unit
  149:2_suppl, p. P244 - P244 2013
• Otolaryngology - Head and Neck Surgery
  Quintanilla-Dieck Lourdes, Effect of systemic lipopolysaccharide-induced inflammation on cytokine levels in the murine cochlea
  149:2, p. 301 - 303 2013
• PloS one
  Karasawa Takatoshi, Identification of Cisplatin-Binding Proteins Using Agarose Conjugates of Platinum Compounds
  8:6 2013
• Hearing Journal
  Steyger Peter S., Ototoxic antibiotics
  66:4, p. 24 - 26 2013
• Hearing Research
  Zhang Ru, Temporal and spatial distribution of gentamicin in the peripheral vestibular system after transtympanic administration in guinea pigs
  298, p. 49 - 59 2013
• Cell Biochemistry and Biophysics
  Wang Tian, Bumetanide Hyperpolarizes Madin-Darby Canine Kidney Cells and Enhances Cellular Gentamicin Uptake by Elevating Cytosolic Ca2+ Thus Facilitating Intermediate Conductance Ca2+-Activated Potassium Channels
  65:3, p. 381 - 398 2013
• PloS one
  Uribe Phillip M., Aminoglycoside-Induced Hair Cell Death of Inner Ear Organs Causes Functional Deficits in Adult Zebrafish (Danio rerio)
  8:3 2013
• PloS one
  Uribe Phillip M., Dimethyl Sulfoxide (DMSO) Exacerbates Cisplatin-induced Sensory Hair Cell Death in Zebrafish (Danio rerio)
  8:2 2013
• Otolaryngology-head and neck surgery
  Quintanilla-Dieck Lourdes, Cytokines Induced by Gentamicin and Sepsis in the Cochlea
  147:2_suppl, p. P84 - P84 2012
• Journal of Clinical Oncology
  Brock Penelope R., Platinum-induced ototoxicity in children
  30:19, p. 2408 - 2417 2012
• Hearing Journal
  Steyger Peter S., Journal club
  65:4, p. 18 - 20 2012
• Hearing Research
  Zhang Yi Bo, Uptake of gentamicin by vestibular efferent neurons and superior olivary complex after transtympanic administration in guinea pigs
  283:1-2, p. 169 - 179 2012
• Natural Product Communications
  Escobedo Jorge O., Live cell imaging of a fluorescent gentamicin conjugate
  7:3, p. 317 - 320 2012
• JARO - Journal of the Association for Research in Otolaryngology
  Stepanyan Ruben S., TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells
  12:6, p. 729 - 740 2011
• Toxicological Sciences
  Karasawa Takatoshi, Calreticulin binds to gentamicin and reduces drug-induced ototoxicity
  124:2, p. 378 - 387 2011
• Integrative Biology
  Karasawa Takatoshi, Intracellular mechanisms of aminoglycoside-induced cytotoxicity
  3:9, p. 879 - 886 2011
• Audiology and Neuro-Otology
  Koo Ja Won, Infection-mediated vasoactive peptides modulate cochlear uptake of fluorescent gentamicin
  16:6, p. 347 - 358 2011
• Seminars in hearing
  Steyger Peter S., Mechanisms Involved in Ototoxicity
  32:3, p. 217 - 228 2011
• Scientific Reports
  Li Hongzhe, Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells
  1 2011
• PloS one
  Alharazneh Abdelrahman, Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity
  6:7 2011
• PloS one
  Li Hongzhe, Acoustic trauma increases cochlear and hair cell uptake of gentamicin
  6:4 2011
• Cell Death and Disease
  Karasawa T., CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity
  1:11 2010
• Laryngoscope
  Zhang Yiliang, Comparison of gentamicin distribution in the inner ear following administration via the endolymphatic sac or round window
  120:10, p. 2054 - 2060 2010
• Hearing Research
  Wang Qi, Competitive antagonism of fluorescent gentamicin uptake in the cochlea
  268:1-2, p. 250 - 259 2010
• Otology and Neurotology
  Zhai Feng, Evidence-Based modification of intratympanic gentamicin injections in patients with intractable vertigo
  31:4, p. 642 - 648 2010
• The FASEB journal
  Wang Tian, Ionic mechanisms for bumetanide enhancement on aminoglycoside ototoxicity: a study with MDCK cells
  24:S1, p. lb486 - lb486 2010
• Brain Research
  Tiede LeAnn, Metabolic imaging of the organ of corti — A window on cochlea bioenergetics
  1277, p. 37 - 41 2009
• JARO - Journal of the Association for Research in Otolaryngology
  Wang Qi, Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells
  10:2, p. 205 - 219 2009
• The FASEB journal
  Ma Ke‐tao, Possible gentamicin trafficking channels in guinea pig cochlear stria vascularis cells
  23:S1 2009
• Seminars in Hearing
  Steyger Peter S., Potentiation of chemical ototoxicity by noise
  30:1, p. 38 - 46 2009
• Noise and Health
  Li Hongzhe, Synergistic ototoxicity due to noise exposure and aminoglycoside antibiotics
  11:42, p. 26 - 32 2009
• Perspectives on hearing and hearing disorders. Research and diagnostics
  Steyger Peter S., Synergistic Ototoxicity of Noise and Chemical Ototoxins
  12:2, p. 48 2008
• Journal of Cell Science
  Karasawa Takatoshi, TRPV4 enhances the cellular uptake of aminoglycoside antibiotics
  121:17, p. 2871 - 2879 2008
• Hearing Research
  Dai Chun Fu, A systemic gentamicin pathway across the stria vascularis
  235:1-2, p. 114 - 124 2008
• Hearing Research
  Hordichok Andrew J., Closure of supporting cell scar formations requires dynamic actin mechanisms
  232:1-2, p. 1 - 19 2007
• Hearing Research
  Dai C. F., Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo
  213:1-2, p. 64 - 78 2006
• Hearing Research
  Myrdal Sigrid E., TRPV1 regulators mediate gentamicin penetration of cultured kidney cells
  204:1-2, p. 170 - 182 2005
• Hearing Research
  Dai C. F., Expression of Trk A receptors in the mammalian inner ear
  187:1-2, p. 1 - 11 2004
• Neuroscience
  Vass Z., Co-localization of the vanilloid capsaicin receptor and substance P in sensory nerve fibers innervating cochlear and vertebro-basilar arteries
  124:4, p. 919 - 927 2004
• JARO - Journal of the Association for Research in Otolaryngology
  Steyger P. S., Uptake of Gentamicin by Bullfrog Saccular Hair Cells in vitro
  4:4, p. 565 - 578 2003
• Journal of Neurophysiology
  Zheng Jiefu, Vanilloid receptors in hearing
  90:1, p. 444 - 455 2003
• Journal of Neurocytology
  Jensen-Smith Heather C., Cell type-specific reduction of β tubulin isotypes synthesized in the developing gerbil organ of Corti
  32:2, p. 185 - 197 2003
• Journal of Neurocytology
  Jensen-Smith H. C., Cell type-specific reduction of β tubulin isotypes synthesized in the developing gerbil organ of Corti
  32:2, p. 185 - 197 2003
• Hearing Research
  Qiu Jian Hua, Co-existence of tyrosine hydroxylase and calcitonin gene-related peptide in cochlear spiral modiolar artery of guinea pigs
  155:1-2, p. 152 - 160 2001
• Journal of Biological Chemistry
  Silberbach Michael, Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes
  274:35, p. 24858 - 24864 1999
• ImmunoMethods
  Steyger Peter, Assessing confocal microscopy systems for purchase
  18:4, p. 435 - 446 1999
• Journal of Neuroscience
  Steyger Peter S., Myosin Iβ is located at tip link anchors in vestibular hair bundles
  18:12, p. 4603 - 4615 1998
• Adler H. J., Early education of the deaf [10] 1998
• Hearing Research
  Baird R. A., Intracellular distributions and putative functions of calcium-binding proteins in the bullfrog vestibular otolith organs
  103:1-2, p. 85 - 100 1997
• Journal of Controlled Release
  Steyger P. S., Intratumoural
  39:1, p. 35 - 46 1996
• Hearing Research
  Steyger P. S., Visualization of newt aragonitic otoconial matrices using transmission electron microscopy
  92:1-2, p. 184 - 191 1995
• Hearing Research
  Hallworth Richard J., Atomic force microscope observations of otoconia in the newt
  85:1-2, p. 115 - 121 1995
• Hearing Research
  Steyger Peter S., The morphogenic features of otoconia during larval development of Cynops pyrrhogaster, the Japanese red-bellied newt
  84:1-2, p. 61 - 71 1995
• British Journal of Cancer
  Seymour L. W., Tumour tropism and anti-cancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16F10 melanoma
  70:4, p. 636 - 641 1994
• Journal of Electron Microscopy Technique
  Furness David N., Organization of microtubules in cochlear hair cells
  15:3, p. 261 - 279 1990
• Hearing Research
  Steyger P. S., Tubulin and microtubules in cochlear hair cells
  42:1, p. 1 - 16 1989
• British Journal of Audiology
  Steyger P. S., Immunocytochemistry of cytoskeletal proteins in the guinea pig cochleaa comparison of staining patterns with different commercially available antibodies and ultrastructure
  23:2, p. 143 - 174 1989

Presentations

• Hospital medication-induced hearing loss presented during ENT Fall Education Series at the Department of Otolaryngology-Head and Neck Surgery at University Hospitals Cleveland Medical Center 2022
• Mechanisms of Drug-induced Hearing Loss during Research Brainstorming virtual meeting 2022
• Poster Presentation: F Taghizadeh, M Jiang, W Meier, P Steyger. TLR4 and MyD88 Activation of TRPV1 Modulates Cellular Uptake of Aminoglycosides. 45th Annual Mid-Winter Meeting of the Association for Research in Otolaryngology, San Jose, CA, 1/2020 2020
• Podium Presentation: F Taghizadeh, M Jiang, W Meier, P Steyger TLR4 and MyD88 activation of TRPV1 modulates cellular uptake of aminoglycosides. 2nd International Society for Inner Ear Therapeutics, Hannover, Germany, 11/2019 2019
• Keynote speaker: Otopathology of ototoxicity and noise exposure: From animal models to audiological management, NCRAR biennial conference, Portland VA, OR, Sept 2019 2019

Awards

• University Research Award
  Creighton University
• Keynote Speaker
  Keynote speaker: Otopathology of ototoxicity and noise exposure: From animal models to audiological management, NCRAR biennial conference, Portland VA, OR, Sept 2019.
  NCRAR biennial conference
• Guest Editor
  Research topic: Cellular Mechanisms of Ototoxicity.
  Frontiers in Celluar Neuroscience
• Guest Editor
  Research topic: Drug delivery to the inner ear.
  Frontiers in Celluar Neuroscience
• Lead Discussant
  Ototoxicity Sub-committee for Pharmaceutical Interventions for Hearing Loss (PIHL), Hearing Center of Excellence, US Department of Defense
  Hearing Center of Excellence (DOD)
• Associate Editor
  Frontiers in Medicine - Translational Medicine