Derek David Smith, PhD

Department

Biomedical Sciences

Position

Professor

Books

• Reference Module in Biomedical Sciences
  David Smith D., Calcitonin Receptor Agents [Book Chapter] 2017
• Reference Module in Biomedical Sciences
  David Smith D., AC187 [Book Chapter] 2016
• xPharm: The Comprehensive Pharmacology Reference
  Abel Peter W., Calcitonin Gene-Related Peptide [Book Chapter] 2011
• xPharm: The Comprehensive Pharmacology Reference
  Smith D. David, Ac187 [Book Chapter] 2011
• xPharm: The Comprehensive Pharmacology Reference
  Smith D. David, Calcitonin Receptor Agents [Book Chapter] 2011
• Peptides for Youth
  Smith D. David, Synthesis of 4-arylmethyl-L-histidine analogues for structure-activity studies of position 10 of CGRP [Book Chapter] 2009

Articles

• Smith D. David, Erratum 1993

Publications

• ACS Infectious Diseases
  Alshammari Abdulraman M., Targeted Amino Acid Substitution Overcomes Scale-Up Challenges with the Human C5a-Derived Decapeptide Immunostimulant EP67
  6:5, p. 1169 - 1181 2020
• Journal of Drug Delivery Science and Technology
  Meerovich Igor, Direct solid-phase peptide synthesis on chitosan microparticles for targeting tumor cells
  54 2019
• International Journal of Pharmaceutics
  Tallapaka Shailendra B., Surface conjugation of EP67 to biodegradable nanoparticles increases the generation of long-lived mucosal and systemic memory T-cells by encapsulated protein vaccine after respiratory immunization and subsequent T-cell-mediated protection against respirat
  565, p. 242 - 257 2019
• Neurobiology of Disease
  Warren Ted J., Adenosine has two faces
  114, p. 45 - 52 2018
• ChemInform
  Smith D. David, ChemInform Abstract: An Efficient Synthesis of 4(5)-Benzyl-l-histidines Employing Catalytic Transfer Hydrogenolysis at Elevated Temperatures
  45:31, p. no - no 2014
• Synthesis (Germany)
  Smith D. David, An efficient synthesis of 4(5)-benzyl- L -histidines employing catalytic transfer hydrogenolysis at elevated temperatures
  46:4, p. 515 - 521 2014
• Synthesis
  Smith D. David, An Efficient Synthesis of 4(5)-Benzyl-L-histidines Employing Catalytic Transfer Hydrogenolysis at Elevated Temperatures
  46:4, p. 515 - 521 2014
• The FASEB journal
  Brauer Philip R., Effects of nicotine on avian neural crest migration and embryonic development
  23:S1 2009
• Chemical Biology and Drug Design
  Taylor Christopher K., N-terminal bis-(2-chloroethyl)amino and fluorosulphonyl analogues of calcitonin gene-related peptide(8-37)
  70:3, p. 216 - 226 2007
• Journal of Pharmacology and Experimental Therapeutics
  Taylor C. K., Pharmacological characterization of novel alpha-calcitonin gene-related peptide (CGRP) receptor peptide antagonists that are selective for human CGRP receptors
  319:2, p. 749 - 757 2006
• Journal of Cell Science
  Vent J., Direct involvement of the isotype-specific C-terminus of beta tubulin in ciliary beating
  118:19, p. 4333 - 4341 2005
• Journal of Peptide Research
  Taylor Christopher K., Solvent effects on coupling yields during rapid solid-phase synthesis of CGRP(8-37) employing in situ neutralization
  65:1, p. 84 - 89 2005
• American Journal of Physiology - Regulatory Integrative and Comparative Physiology
  Reidelberger Roger D., Amylin receptor blockade stimulates food intake in rats
  287:3 56-3, p. R568 - R574 2004
• American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
  Reidelberger Roger D., Amylin receptor blockade stimulates food intake in rats
  56:3, p. R568 - R574 2004
• Biochemical and Biophysical Research Communications
  Conlon J. M., The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei
  320:1, p. 170 - 175 2004
• Biochemical and Biophysical Research Communications
  Conlon J. Michael, The ascaphins
  320:1, p. 170 - 175 2004
• Taylor Christopher K., NMP is unsuitable as a solvent for the rapid solid phase synthesis of CGRP(8-37) using in situ neutralization 2004
• Journal of Medicinal Chemistry
  Smith D. David, Modifications to the N-terminus but not the C-terminus of calcitonin gene-related peptide(8-37) produce antagonists with increased affinity
  46:12, p. 2427 - 2435 2003
• Journal of Pharmacology and Experimental Therapeutics
  Rorabaugh Boyd R., Functional calcitonin gene-related peptide subtype 2 receptors in porcine coronary arteries are identified as calcitonin gene-related peptide subtype 1 receptors by radioligand binding and reverse transcription-polymerase chain reaction
  299:3, p. 1086 - 1094 2001
• Journal of Pharmaceutical Sciences
  Stratton Lewis P., Controlling deamidation rates in a model peptide
  90:12, p. 2141 - 2148 2001
• Journal of Peptide Research
  Bachle L. A., Isolation and characterization of insulin from the Brockmann body of Dissostichus mawsoni, an Antarctic teleost fish
  56:1, p. 47 - 54 2000
• Journal of Pharmacology and Experimental Therapeutics
  Waugh David J.J., Limitations in using peptide drugs to characterize calcitonin gene- related peptide receptors
  289:3, p. 1419 - 1426 1999
• FASEB Journal
  Guynn S. R., Regulation of chloride cell oxygen consumption in Antarctic fish
  12:5, p. A1026 1998
• Journal of Peptide Research
  Saha S., Role of conformational constraints of position 7 of the disulphide bridge of h-α-CGRP derivatives in their agonist versus antagonist properties
  52:2, p. 112 - 120 1998
• Methods in molecular biology (Clifton, N.J.)
  Smith D. D., Purification of synthetic peptides by high performance liquid chromatography.
  73, p. 75 - 87 1997
• Journal of Medicinal Chemistry
  Li Jianzhong, Structure-Activity studies on position 14 of human α-calcitonin gene- related peptide
  40:19, p. 3071 - 3076 1997
• American Journal of Physiology - Regulatory Integrative and Comparative Physiology
  Le Mevel Jean Claude, Cardiovascular actions of trout urotensin II in the conscious trout, Oncorhynchus mykiss
  271:5 40-5, p. R1335 - R1343 1996
• FASEB Journal
  Waugh David, Cgrp receptors on porcine arteries
  10:3, p. A697 1996
• International Journal of Peptide and Protein Research
  SMITH D. DAVID, Solid‐phase peptide synthesis and biological activity of bovine thymopoietin II (bTP–11)
  44:2, p. 183 - 191 1994
• Biochemical Society Transactions
  Lovas S., Structure-activity relationships of para-substituted Phe analogues of [Nle10]NKA(4-10)
  22:1, p. 5S 1994
• Tetrahedron Letters
  Haver Alvin C., Effect of solvent on racemization in carbodiimide mediated solid phase fragment condensations
  34:14, p. 2239 - 2242 1993
• Journal of the Chemical Society, Perkin Transactions 1
  Smith D. David, Phosphorus-based reagents in peptide synthesis, p. 551 - 556 1993
• Biochemistry
  Lippens G., Transfer Nuclear Overhauser Effect Study of the Conformation of Oxytocin Bound to Bovine Neurophysin I
  32:36, p. 9423 - 9434 1993
• Journal of Medicinal Chemistry
  Smith D. David, Synthesis and Biological Activity of C-Terminally Truncated Fragments of Human α-Calcitonin Gene-Related Peptide
  36:17, p. 2536 - 2541 1993
• Journal of Medicinal Chemistry
  Smith D. David, Structure-Activity Studies of a Novel Bicyclic Oxytocin Antagonist
  35:9, p. 1558 - 1563 1992
• Neuroendocrinology
  Michael Conlon J., Purification and characterization of urotensin II and parvalbumin from an elasmobranch fish, Scyliorhinus canicula (common dogfish)
  55:2, p. 230 - 235 1992
• Brain Research
  Caldwell J. D., A uterotonic antagonist blocks the oxytocin-induced facilitation of female sexual receptivity
  512:2, p. 291 - 296 1990
• Endocrinology
  Conlon J. Michael, Isolation and biological activity of a novel kinin ([thr6] bradykinin) from the turtle, pseudemys scripta
  126:2, p. 985 - 991 1990
• Annual Review of Pharmacology and Toxicology
  Hruby V. J., Conformational and structural considerations in oxytocin-receptor binding and biological activity
  30, p. 501 - 534 1990
• Journal of the American Chemical Society
  Hill Patricia S., Bicyclization of a Weak Oxytocin Agonist Produces a Highly Potent Oxytocin Antagonist
  112:8, p. 3110 - 3113 1990

Presentations

• Eric Steele; D. David Smith "Preparation of 4(5)-benzyl-L-histidine methyl ester". Oral presentation at the 2017 Nebraska Academy of Sciences Annual Meeting, Nebraska Wesylean University, Lincoln, NE. April 21, 2017. 2017
• Nick Mason; Martin Hulce; David Smith "Synthesis of Truncated Calcitonin Gene-Related Peptide (8-11) by Fmoc coupling with Modified Hisitidne". Poster #31 presentation, 2017 St. Albert's Day Student Research Forum, Creighton University, Omaha, NE March 30, 2017. 2017
• D. David Smith; Eric Steele; Paul Lievens; Martin R. Hulce "Preparation of 4(5)-benzyl-L-histidine methyl ester and its DiBoc derivative". Poster #32 presentation 2017 St. Albert's Day Student Research Forum, Creighton University, Omaha, NE March 30, 2017. 2017
• D. David Smith, Eric Steele, Paul Lievens, Martin R. Hulce "Preparation of 4(5)-benzyl-L-histidine methyl ester". Poster #380 presentation at the 51st Midwest Regional Meeting American Chemical Society, Kansas State University, Manhatten, KS. October 26-28, 2016. 2016
• N.J. Mason; M.R. Hulce; D.D. Smith "Synthesis of trncated calcitonin gene-related peptide analogues by Fmoc coupling with modified histidines". Poster #191 presentation at the 51st Midwest Regional Meeting American Chemical Society, Kansas State University, Manhattan, KS. October 26-28, 2016. 2016
• B.M. Cokington, K.P. Cokington, M. Hulce, R.T. Ishihara, D.D. Smith, E.M. Villa Sterically Directed Imidazole Side Chain Protection Strategies for Preparation of 4(5)-Benzyl-L-histidine Peptide Synthesis Reagents, poster presentation at St. Albert's Day/University Research Day, Creighton University, Omaha, NE April 14, 2015. 2015
• I. Meerovich, A.K. Dash, D.D. Smith, M.Hulce Direct Solid Phase Peptide Synthesis on Chitosan Microparticles for Tumor Targeting, poster presentation at St. Albert's Day/University Research Day, Creighton University, Omaha, NE April 14, 2015 2015
• D.D. Smith, H. Roundtree, T. Simeone, K. Simeone Use of Reversed-Phase High Performance Liquid Chromatography to Measure Adenosine Amounts in Mouse Brain, poster presentation at the 2014 American Chemical Society Midwest Regional Meeting, University of Missouri, Columbia, MO November 12-15, 2014. 2014
• B.M. Cokington, K.P. Cokington, R.T. Ishihara, M. Hulce, D.D. Smith, Sterically Directed Imidazole Side Chain Protection Strategies for Preparation of 4(5)-Benzyl-L-histidines Suitable for Solid Phase Peptide Synthesis, poster presentation at the 2014 American Chemical Society Midwest Regional Meeting, University of Missouri, Columbia, MO November 12-15, 2014 2014
• I. Meerovich, A.K. Dash, D.D. Smith, M. Hulce Direct Solid Phase Peptide Synthesis on Chitosan Microparticles for Tumor Targeting, poster presentation at 2014 AAPS Annual Meeting and Exposition, San Diego Convention Center, San Diego, CA November 2-6, 2014. 2014
• D.D. Smith, C. Griggs, B. Mitchell, H. Mekada, M. Hulce Preparation of Protected Derivatives of 4(5)-Benzyl-L-Histidines, 2nd All University Research Fair, Creighton University, Omaha, NE September 25, 2014 2014
• D.D. Smith, C. Griggs, B. Mitchell, H. Mekada, M. Hulce Preparation of Protected Derivatives of 4(5)-Benzyl-L-Histidine, poster presentation at 248th Fall American Chemical Society National Meeting and Exposition, San Francisco, CA August 10-14, 2014 2014
• Benjamin Mitchell; D. David Smith; Martin Hulce "Preparation of Nalpha,Ntau-bis(t-butoxycarbonyl)-4(5)-benzyl-L-histidine Methyl Ester". Oral presentation, 124th Nebraska Academy of Sciences, Lincoln, NE April, 4, 2014. 2014
• Connor Griggs; Martin Hulce; D. David Smith "Studies Towards the Synthesis of N-methyl-L-beta-hydroxvaline using the Schollkopf Chiral Auxiliary". Oral presentation, 124th nebraska Academy of Sciences, Lincoln NE April 4, 2014. 2014
• Benjamin Mitchell; D. David Smith; Martin Hulce "Preparation of Nalpha,Ntau-bis(t-butoxycarbonyl)-4(5)-benzyl-L-histidine Methyl Ester". Poster presentation, 124th Nebraska Academy of Sciences, Lincoln, NE April, 1, 2014. 2014
• Connor Griggs; Martin Hulce; D. David Smith "Studies Towards the Synthesis of N-methyl-L-beta-hydroxvaline using the Schollkopf Chiral Auxiliary". Poster presentation, 124th Nebraska Academy of Sciences, Lincoln NE April 4, 2014. 2014
• The benzylation of histidyl residues during peptide synthesis, Invited speaker, Department of Chemistry weekly seminar, University of Nebraska Omaha, Omaha NE November 11, 2013. 2013
• D. David Smith; Connor N. Griggs; Martin Hulce "Synthesis of N-Methyl-L-beta-hydroxyvaline Using The Schollkopf Chiral Auxiliary". Poster presentation, 48th Midwest Regional Meeting of the American Chemical Society, Springfield, MO October 16-19, 2013. 2013
• Hideaki Mekada; Martin Hulce; D. David Smith "Synthesis of a 4(5)-L-histidinyl Peptide Using Fmoc-based Solid-phase Peptide Synthesis". Poster presentation, 48th Midwest Regional Meeting of the American Chemical Society, Springfield, MO October 16 - 19, 2013. 2013
• Connor Griggs; Martin Hulce; D. David Smith "Studies Towards the Synthesis of N-methyl-L-beta-hydroxvaline using the Schollkopf Chiral Auxiliary". Oral presentation, 12th NE-INBRE Conference, Grand Island, NE August 4-6, 2013. 2013
• Poster presentation at the 20th American Peptide Symposium in Montreal, Canada. 2007
• Poster. Smith DD, Taylor CK, Abel PW, Hulce MR, Competitive and irreversible antagonists of CGRP. 30th National Medicinal Chemistry Symposium, Seattle, WA. 2006
• Oral Presentation: Smith DD, Taylor CK, Abel PW, Hulce MR, Competitive and irreversible antagonists of calcitonin gene-related peptide. 116th Nebraska Academy of Sciences Meeting, Lincoln, NE. 2006
• Poster Presentation: Taylor CK, Smith DD, Abel, PW. Pharmacological characterization of novel high affinity CGRP receptor antagonists that are selectice for human CGRP receptors. Experimental Biology, ASPET section, San Francisco, CA. 2006
• Poster Presentation: Taylor CK, Smith DD, Abel, PW. Pharmacological characterization of novel high affinity CGRP receptor antagonists that are selectice for human CGRP receptors. Experimental Biology, Drug Discovery, Drug Development and Regulatory Affairs Young Investigator Section, San Francisco, CA. 2006
• Oral Presentation: Taylor CK, Smith DD, Abel PW. Pharmacological characterization novel high affinity CGRP receptor antagonists that are selective for human CGRP receptors. 37th Midwest Student Biomedical Research Forum, Omaha, NE. 2006
• Poster D31. Smith, DD, Taylor, CK, Abel, PW, Hulce, M Synthesis of Irreversible antagonists of CGRP receptors. National Organic Chemistry Symposium, 2005, Salt Lake City, UT. 2005
• Poster. Taylor, CK, Smith, DD, Abel, PW Characterization of irreversible antagonists of calcitonin gene-related peptide receptors. Nebraska EpSCOR meeting, 2005, Omaha, NE. 2005
• Taylor, CK, Smith, DD, Abel, PW Pharmacological Characterization of calcitonin gene-related peptide receptors. St. Albert's Day symposium, 2005, Omaha, NE. 2005
• Poster. Taylor, CK, Smith, DD, Abel, PW, Pharmacological characterization of irreversible antagonists of calcitonin gene-related peptide receptors. Experimental Biology, 2005, San Diego, CA. 2005
• Lecture. Taylor, CK, Abel, PW, Smith, DD, Synthesis and pharmacological characterization of novel irreversible antagonists of CGRP receptors. 36th Midwest Student Biomedical Research Conference, 2005, Omaha, NE. 2005
• Poster. Taylor, CK, Abel, PW, Smith, DD, Synthesis and pharmacological characterization of novel irreversivle antagonists of CGRP receptors. Neuroscience meeting, 2004, Omaha, NE. 2004
• Synthesis and Pharmacological Characterization of CGRP8-37 Analogues Containing N-"Terminal (bis(2- chloroethyl)-amino) and p-(fluorosulfonyl) Alkylating Moieties" poster presentation at Experimental Biology 2004 meeting in Washington DC, April 17-21, 2004. 2004
• "SYNTHESIS OF PUTATIVE IRREVERSIBLE ANTAGONISTS OF CGRP RECEPTORS CONTAINING N-TERMINAL (BIS-(2-CHLOROETHYL)-AMINO) AND P-(FLUOROSULFONYL) GROUPS" Lecture presentation at the 114th Annual Meeting of the Nebraska Academy of Sciences, Nebraska Wesleyan University, Lincoln NE 2004
• "SYNTHESIS OF PUTATIVE IRREVERSIBLE ANTAGONISTS OF CGRP RECEPTORS CONTAINING N-TERMINAL (BIS-(2-CHLOROETHYL)-AMINO) AND P-(FLUOROSULFONYL) GROUPS" poster presentation at the Peptides, Chemistry & Biology of, Gordon Research conference, Ventura, CA February 15-20, 2004. 2004
• Taylor CK, Abel PW, Smith DD, NMP is unsuitable as a solvent for the rapid solid phase synthesis of CGRP8-37 using in situ neutralization. Poster presentation at the American Peptide symposium, Boston ME. July 19-24, 2003. 2003
• Taylor CK, Abel PW, Smith DD NMP is unsuitable as a solvent for the rapid solid phase synthesis of CGRP(837) using in situ neutralization. An oral presentation at the Nebraska Academy of Sciences, Nebraska Wesleyan University, Lincoln, NE. 2003
• Taylor, C.K.; Abel, P.W.; Smith, D.D. Synthesis and pharmacological characterization of a novel high affinity CGRP receptor antagonist. Poster presentation at Experimental Biology 2002, New Orleans, LA April 20-24, 2002. 2002
• Rorabaugh, B.R.; Abel, P.W.; Smith, D.D.; Scofield, M.A. Putative CGRP2 receptors are identified as adrenomedullin receptors in SV40LT-SMC cells. Poster presentation at Experimental Biology 2002, New Orleans, LA April 20-24, 2002. 2002
• Use of Calcitonin Gene-Related Peptide (CGRP) antagonists to Characterize CGRP receptors, D. David Smith, Boyd R. Rorabaugh, Margaret A. Scofield, Peter W. Abel Poster Presentation at Gordon Research Conference, Chemistry & Biology of Peptides, Ventura Beach, CA February 17 - 22, 2002. 2002
• "Development of CGRP antagonists and their use." Invited seminar speaker, Dept. of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO. 2002
• "Benzylation of the Amino Terminus of the Peptide Antagonist CGRP(8-37) Leads to Formation of a Dibenzylated Byproduct" D. David Smith, Martin R. Hulce, David J.J. Waugh, Peter W. Abel, 36th Midwest Regional Meeting of the American Chemical Society, Lincoln, NE. 2001 2001
• Structural characterization of a dibenzylated-CGRP(8-37), a byproduct from n-alpha-benzylation of CGRP(8-37), 2nd International Peptide Symposium/ 17th American Peptide Symposium, San Diego, CA. Poster presentation. 2001
• CGRP receptor signaling in SK-N-MC and HEK293 cells. 4th Nebraska Physiological Society meeting, Omaha, NE. Poster presentation. 2001
• CGRP receptor signaling pathway in SK-N-MC and HEK293 cells, FASEB2001, Orlando, FL. Poster presentation 2001
• Pharmacological Comparison of Porcine CGRP receptors, Midwest Student Biomedical Research Forum, Omaha, NE. Poster presentation. 2001
• Isolation and characterization of insulin from the Brockmann Body of dissostichus Mawsoni, an Antarctic teleost, 26th European Peptide Symposium, Montpellier, France. Poster presentation. 2000
• Blocking the N-terminus of Calcitonin Gene-Related Peptide(8-37) produces high affinity antagonists. 26th European Peptide Symposium, Montpellier, Fance. Poster presentation 2000
• FASEB & Gastroenterology meetings 1999
• Rosehill Elementary School, Omaha. 1999

Awards

• Intramural Research Award
  Recipient of a CURAS Faculty Research Fund Award for undergraduate research, $4,500, June 1, 2014 through April 30th, 2015.
• The Welcome Trust, United Kingdom.