Timothy A . Simeone, PhD

Department

Pharmacology and Neuroscience

Position

Professor

Books

• Ketogenic Diet and Metabolic Therapies
  Masino Susan A., Ketogenic Diet and PPARγ [Book Chapter] 2022
• Ketogenic Diet and Metabolic Therapies
  Boison Detlev, Ketogenic Diet and PPARgamma [Book Chapter] 2016
• The Curated Reference Collection in Neuroscience and Biobehavioral Psychology
  Simeone T. A., Antiepileptic drugs [Book Chapter] 2016
• Homeostatic Control of Brain Function
  Simeone Kristina, Sleep [Book Chapter] 2015
• Epilepsy : Mechanisms, Models, and Translational Perspectives
  Simeone Timothy A., Mechanisms of antiepileptic drug action [Book Chapter] 2010
• Encyclopedia of Basic Epilepsy Research
  Simeone T. A., Antiepileptic Drugs [Book Chapter] 2009
• Encyclopedia of Basic Epilepsy Research
  Simeone Timothy A., Antiepileptic Drug Mechanisms [Book Chapter] 2009

Publications

• Neurobiology of disease
  Iyer Shruthi H., Altered ventilatory responses to hypercapnia-hypoxia challenges in a preclinical SUDEP model involve orexin neurons
  199, p. 106592 2024
• Biomolecules (Basel, Switzerland)
  Baker Carly E., CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression
  14:8, p. 914 2024
• Nutrients
  Iyer Shruthi H, Dietary and Metabolic Approaches for Treating Autism Spectrum Disorders, Affective Disorders and Cognitive Impairment Comorbid with Epilepsy: A Review of Clinical and Preclinical Evidence
  16:4 2024
• Epilepsy currents
  Simeone Timothy, The Unconventional Effects of the Ketogenic Diet (KD) in Preclinical Epilepsy 2024
• European journal of pharmacology
  Kostansek, 4th Joseph A, Orexin receptors regulate hippocampal sharp wave-ripple complexes in ex vivo slices
  950, p. 175763 - 175763 2023
• Frontiers in Neurology
  Hampson Johnson P., Functional MRI Correlates of Carbon Dioxide Chemosensing in Persons With Epilepsy
  13 2022
• Nutrients
  Heruye Segewkal H., Ascorbic Acid Reduces Neurotransmission, Synaptic Plasticity, and Spontaneous Hippocampal Rhythms in In Vitro Slices
  14:3 2022
• European Journal of Pharmacology
  Deodhar Malavika, Pharmacoresponsiveness of spontaneous recurrent seizures and the comorbid sleep disorder of epileptic Kcna1-null mice
  913 2021
• Epilepsia
  Simeone Kristina A., Ketogenic diet–mediated seizure reduction preserves CA1 cell numbers in epileptic Kcna1-null mice
  62:8, p. e123 - e128 2021
• Brain Sciences
  Simeone Timothy A., Carbamazepine reduces sharp wave-ripple complexes and exerts synapse-specific inhibition of neurotransmission in ex vivo hippocampal slices
  11:6 2021
• Metabolomics
  Johnson Alicia, Changes in lipid profiles of epileptic mouse model
  16:10 2020
• Journal of Proteomics
  Grove Ryan A., Aberrant energy metabolism and redox balance in seizure onset zones of epileptic patients
  223 2020
• Epilepsia
  Iyer Shruthi H., Progressive cardiorespiratory dysfunction in Kv1.1 knockout mice may provide temporal biomarkers of pending sudden unexpected death in epilepsy (SUDEP)
  61:3, p. 572 - 588 2020
• Epilepsy Currents
  Jobst Barbara C., Highlights From the Annual Meeting of the American Epilepsy Society 2018
  19:3, p. 152 - 158 2019
• Epilepsy Research
  Knowles Sara, Ketogenic diet regulates the antioxidant catalase via the transcription factor PPARγ2
  147, p. 71 - 74 2018
• Neurobiology of Disease
  Warren Ted J., Adenosine has two faces
  114, p. 45 - 52 2018
• Neuropharmacology
  Simeone Timothy A., Do ketone bodies mediate the anti-seizure effects of the ketogenic diet?
  133, p. 233 - 241 2018
• Epilepsia
  Simeone Kristina A., Respiratory dysfunction progresses with age in Kcna1-null mice, a model of sudden unexpected death in epilepsy
  59:2, p. 345 - 357 2018
• Epilepsia
  Iyer Shruthi H., Accumulation of rest deficiency precedes sudden death of epileptic Kv1.1 knockout mice, a model of sudden unexpected death in epilepsy
  59:1, p. 92 - 105 2018
• Epilepsia
  Simeone Kristina A., Synergistic Protection Against Acute Flurothyl-Induced Seizures by Adjuvant Treatment of the Ketogenic Diet with the Type 2 Diabetes Drug Pioglitazone
  58:8, p. 1440 - 1450 2017
• Neurochemical Research
  Simeone Kristina A., Ketone Bodies as Anti-Seizure Agents
  42:7, p. 2011 - 2018 2017
• Experimental Neurology
  Simeone Kristina A., Regulation of Brain PPARgamma2 Contributes to Ketogenic Diet Anti-Seizure Efficacy
  284:Part 1, p. 54 - 64 2017
• Epilepsia
  Simeone Timothy A., Ketogenic Diet Treatment Increases Longevity in Kcna1-Null Mice, a Model of Sudden Unexpected Death in Epilepsy
  57:8, p. e178 - e182 2016
• Sleep
  Roundtree Harrison M., Orexin Receptor Antagonism Improves Sleep and Reduces Seizures in Kcna1-Null Mice
  39:2, p. 357 - 368 2016
• Annals of Neurology
  Kim do Y., Ketone bodies mediate antiseizure effects through mitochondrial permeability transition
  78:1, p. 77 - 87 2015
• Epilepsia
  Simeone Kristina A., In Vivo Ketogenic Diet Treatment Attenuates Pathologic Sharp Waves and High Frequency Oscillations in in Vitro Hippocampal Slices from Epileptic Kv 1.1α Knockout Mice.
  55:5, p. e44 - e49 2014
• Experimental Neurology
  Simeone Timothy A., Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures
  251, p. 84 - 90 2014
• Neurobiology of Disease
  Simeone Kristina A., Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices
  54, p. 68 - 81 2013
• Epilepsy Research
  Simeone Timothy A., CAMP-Dependent protein kinase A activity modulates topiramate potentiation of GABA A receptors
  96:1-2, p. 176 - 179 2011
• Pharmacological Research
  Simeone Timothy A., Topiramate modulation of β1- and β3- homomeric GABAA receptors
  64:1, p. 44 - 52 2011
• Epilepsia
  Simeone Timothy A., L-type calcium channel blockade reduces network activity in human epileptic hypothalamic hamartoma tissue
  52:3, p. 531 - 540 2011
• Epilepsia
  Kim Do Young, GABAA receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas
  49:5, p. 861 - 871 2008
• Seminars in Pediatric Neurology
  Fenoglio Kristina A., Hypothalamic Hamartoma
  14:2, p. 51 - 59 2007
• Journal of Neurochemistry
  Kim Do Young, Ketone bodies are protective against oxidative stress in neocortical neurons
  101:5, p. 1316 - 1326 2007
• European Journal of Pharmacology
  Simeone Timothy A., Felbamate is a subunit selective modulator of recombinant γ-aminobutyric acid type A receptors expressed in Xenopus oocytes
  552:1-3, p. 31 - 35 2006
• Neuropharmacology
  Simeone Timothy A., Subunit selectivity of topiramate modulation of heteromeric GABAA receptors
  50:7, p. 845 - 857 2006
• Journal of Physiology
  Simeone T. A., Single channel properties of hyperpolarization-activated cation currents in acutely dissociated rat hippocampal neurones
  568:2, p. 371 - 380 2005
• Richichi C, Seizures reduce the expression of the hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channel I via Ca++/calmodulin dependent protein kinase II activation 2005
• Journal of child neurology
  Simeone Timothy A., Molecular biology and ontogeny of glutamate receptors in the mammalian central nervous system
  19:5, p. 343 - 360 2004
• Neurochemical Research
  Poulsen Claus F., Modulation by Topiramate of AMPA and Kainate Mediated Calcium Influx in Cultured Cerebral Cortical, Hippocampal and Cerebellar Neurons
  29:1, p. 275 - 282 2004
• Journal of child neurology
  Simeone Timothy A., Molecular biology and ontogeny of γ-Aminobutyric acid (GABA) receptors in the mammalian central nervous system
  18:1, p. 39 - 48 2003

Presentations

• Kostansek JA IV, Simeone TA, Simeone KA. The Role of Orexin in Hippocampal Physiology. 52nd Annual Midwest Student Biomedical Research Forum, Omaha, NE, 2021. 2021
• Heruye SH, Warren TJ, Simeone KA, Simeone TA. Physiological Concentrations of Ascorbic Acid Impair Basal Synaptic Transmission and Molecular Correlates of Memory. 52nd Annual Midwest Student Biomedical Research Forum. Omaha, NE, 2021. 2021
• Yeh M, Deodhar M, Simeone, KA Simeone TA. Characterizing Neurons Differentiated From NTera2/CL.D1 (NT2) Cells. 52nd Annual Midwest Student Biomedical Research Forum, Omaha, NE,, 2021. 2021
• Yeh M, Deodhar M, Simeone KA, Simeone TA. Characterizing Neurons Differentiated From NTera2/CL.D1 (NT2) Cells. Asian Pacific American Medical Student Association National Conference, Virtual, 2021. 2021
• Yeh M, Deodhar M, Simeone KA, Simeone TA. Characterizing an AraC-Differentiated NT2 Population. 2020 Creighton Neuroscience Symposium, Omaha, NE, 2020. 2020
• Heruye SH, Warren TJ, Simeone KA, Simeone TA. Concentration dependent effect of ascorbic acid on molecular correlates of memory. 2020 Creighton Neuroscience Symposium, Omaha, NE, 2020. 2020
• Kostansek JA IV, Simeone TA, Simeone KA. The Role of Orexin in Hippocampal Physiology. 2020 Creighton Neuroscience Symposium, Omaha, NE, 2020. 2020
• Heruye, SH., Warren, TJ., Simeone, KA, Simeone TA. Effects of complex I of the electron transport chain on different forms of synaptic plasticity. 51st Annual Midwest Student Biomedical Research Forum, Omaha, NE, 2020 2020
• Yeh M, Deodhar M, Simeone KA, Simeone TA. Characterizing Neurons Differentiated From NTera2/CL.D1 (NT2) Cells. 51st Annual Midwest Student Biomedical Research Forum, Omaha, NE,, 2020. 2020
• Heruye S, Warren T, Simeone KA, Simeone TA. Effects of Complex I of the Electron Transport Chain on Synaptic Plasticity. Park City Epilepsy Meeting, Park City, UT, 2019. 2019
• Warren TJ, Simeone TA, Simeone KA. Excessive Silencing of Orexin Neurons by Protons in a Mouse Model of Epilepsy and SUDEP. American Epilepsy Society, New Orleans, LA, 2018. 2018
• 6th Global Symposium on Ketogenic Therapies, Jeju, Korea. Title: The role of PPARgamma in Epilepsy and KD efficacy. 2018
• Spring Brain conference, Sedona, AZ. Title: Insights into Antiseizure Mechanisms Through the Lens of Dietary Therapies. 2018
• Gavrilovici, Simeone TA, Rho JM. Hippocampal interneuron dysfunction in the Kcna1-null mouse model of epilepsy. American Epilepsy Society, Washington, D.C., 2017. 2017
• Warren TJ, Samson K, Roundtree H, Simeone TA, Simeone KA. Differences in adenosine tone and inhibition in the hypothalamus and hippocampus of Kcna1 KO mice. American Epilepsy Society, Washington, D.C., 2017. 2017
• Iyer S, Matthews S, Maganti R, Simeone TA, Simeone KA. Disrupted rest-active rhythms precedes sudden death in epilepsy Kv1.1 knockout mouse model. American Epilepsy Society, Washington, D.C., 2017. 2017
• Knowles S, Budney, Mattews SA, Deodhar M, Simeone KA, Simeone TA. The ketogenic diet regulates catalase via the transcription factor peroxisome proliferator activated receptor gamma 2. Society for Neuroscience annual meeting, Washington, D.C., 2017. 2017
• Deodhar M, Thomas B, Adamian L, Matthews SA, Simeone KA, Simeone TA. Pharmacoresponsivness of seizures and sleep-wake patterns of Kcna1-null mice, a model of temporal lobe epilepsy with co-morbid sleep disorders to conventional anti-seizure drugs (ASDs). Society for Neuroscience annual meeting, Washington, D.C., 2017. 2017
• Knowles S, Budney S, Kansal V, Mattews SA, Simeone TA. The Role of Catalase in the Ketogenic Diet. St. Albert's Research Day, Creighton University, Omaha, NE, 2017. 2017
• Budney S, Knowles S, Kansal V, Mattews SA, Simeone TA. Elucidating the Effects of PPARγ2 Mediated by the Ketogenic Diet in Refractory Epilepsy. Midwest Student Biomedical Research Forum, Omaha, NE, 2017. 2017
• Adamian L, Matthews SA, Simeone TA, Simeone KA. Phenobarbital improves sleep in Kcan1-null mice. Midwest Student Biomedical Research Forum, Omaha, NE, 2017. 2017
• Thomas B, Matthews SA, Simeone TA. Kcna1-null mice, a model of refractory epilepsy? Midwest Student Biomedical Research Forum, Omaha, NE, 2017. 2017
• American Epilepsy Society annual meeting, Houston, TX. Dietary Therapy Special Interest Group. Title: PPARgamma and the Ketogenic Diet. 2016
• Deodhar M, Matthews SA, Simeone TA. Characterization of a Modified Flurothyl Kindling Model. American Epilepsy Society, Houston, TX, 2016. 2016
• Iyer S, Aggarwal A, Matthews SA, SimeoneTA, Simeone KA. Does progressive elevation in orexinergic activity promote bradycardia in Kv1.1 KO mice, a model of SUDEP? American Epilepsy Society, Houston, TX, 2016. 2016
• 5th Global Symposium on Ketogenic Therapies, Banff, Alberta, Canada. Investigator's Workshop session on Basic Research Highlights. Title: PPARgamma and the Ketogenic Diet. 2016
• Simeone TA, Matthews SA, Simeone KA. Synergistic antiseizure effects of the ketogenic diet and the Type II Diabetes drug pioglitazone on acute flurothyl-induced seizures. 5th Global Symposium on Ketogenic Therapies, Banff, Alberta, Canada, 2016. 2016
• Simeone KA, Matthews SA, Rho JM, Simeone TA. Ketogenic diet treatment increases longevity in Kcna1-null mice, a model of sudden unexpected death in epilepsy. 5th Global Symposium on Ketogenic Therapies, Banff, Alberta, Canada, 2016. 2016
• American Epilepsy Society annual meeting, Philadelphia, PA. Investigator's Workshop session on Targeting Mitochondrial Function as an Antiseizure Strategy. Title: Contributions of Mitochondrial Dysfunction to Network Hyperexcitability. 2015
• Deodhar M, Matthews SA, Simeone KA, Simeone TA. Development of a Modified Flurothyl Kindling Model. American Epilepsy Society, Philadelphia, PA, 2015. 2015
• Aggarwal A, Deodhar M, Simeone KA, Simeone TA. Infiltration of Leukocytes into the Brain of Epileptic Kcna1-null Mice. American Epilepsy Society, Philadelphia, PA, 2015. 2015
• Gavrilovici C, Simeone TA, Rho JM. Interneuronopathy in the Kcna1-null mouse model of epilepsy. American Epilepsy Society, Philadelphia, PA, 2015. 2015
• Kansal V, Aggarwal A, Matthews SA, Oldenburg P, SimeoneTA, Simeone KA. A Longitudinal Study of Respiratory Function of Epileptic Kcna1-Null Mice Using Non-Invasive Airway Mechanincs (NAM). American Epilepsy Society, Houston, TX, 2016. 2015
• 3. Iyer S, Matthews SA, Samson KK, Simeone KA, Simeone TA. Antiseizure Effects Of Ketogenic Diet Are Mediated Via Regulation Of Brain PPAR-gamma, A Nutritionally Responsive Transcription Factor. ADD Program Symposium, Park City, UT, May, 2015. 2015
• 1. Roundtree HM, Matthews SA, Johnson CC, Simeone TA, Simeone KA. Effects of Dual Orexin Receptor Antagonism on Sleep and Seizures in the Kcna1-null Model of Epilepsy. ADD Program Symposium, Park City, UT, May, 2015. 2015
• 2. Deodhar M, Aggarwal A, Simeone TA, Simeone KA. Preliminary evidence of adaptive immune cell infiltration into the brain of a genetic model of chronic epilepsy. ADD Program Symposium, Park City, UT, May, 2015. 2015
• 2015 Creighton University School of Medicine, Omaha, NE. Department of Biomedical Sciences. Research Rounds Seminar Series. Title: The role of brain PPARs in the anti-seizure efficacy ketogenic diet. 2015
• University of Utah School of Pharmacy, Salt Lake City, UT. Department of Pharmacology and Toxicology. Title: Ketogenic Diet Therapy for Epilepsy: Searching for a Mechanism. 2015
• 2015 Creighton University School of Medicine, Omaha, NE. Department of Pharmacology. Research Rounds Seminar Series. Title: Optogenetic Use in Epilepsy: examples from the literature. 2015
• Neuroscience Journal Club. On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy. 2015
• Simeone TA, Matthews SA, Samson KK, Simeone KA. Brain PPARgamma mediates ketogenic diet anti-seizure efficacy. American Epilepsy Society, Seattle, WA, 2014. 2014
• 2014 American Epilepsy Society annual meeting, Seattle, WA. Ketogenic Diet Special Interest Group. Title: Is the ketogenic diet a disease modifying therapy for Epilepsy? The basic science perspective. 2014
• 2014 Society for Neuroscience annual meeting, Washington D.C. Nanosymposium. Title: Brain PPARgamma contributes to the anti-seizure efficacy of the ketogenic diet. 2014
• Simeone KA, Roundtree HM, Samson KK, Simeone TA. Consequences of seizure propagation to the sleep regulating lateral hypothalamus. Society for Neuroscience, Washington D.C., 2014. 2014
• 2014 University of Nebraska Medical Center, Omaha, NE. Department of Neurological Sciences. Current and Future Directions for Translational Epilepsy Research Seminar Series. Title: PPARgamma involvement in Ketogenic Diet Therapy for Refractory Epilepsy. 2014
• "Seizure Propagation to the Lateral Hypothalamus and Sleep-Wake Triggers" Oregon Health Science University, Portland, OR 2014
• "Mechanisms of Hippocampal Network Hyperexcitability in Kv1.1alpha Knockout Mice" Department of Pharmacology Research Rounds, Creighton University, Omaha, NE 2014
• Samson KK, Simeone KA, Rho JM, Simeone TA. Effects of Ketogenic Diet and Constituents on Pathologic Sharp Waves and High Frequency Oscillations. American Epilepsy Society, San Diego, CA, December, 2012. 2012
• Simeone KA, Stephanie A. Matthews SA, Samson KK, Simeone TA. A Novel Mitochondria-targeted Anticonvulsant Treatment. American Epilepsy Society, San Diego, CA, December, 2012. 2012
• Roundtree HM, Samson KK, Simeone TA, Simeone KA. Evidence of Pathology in the Lateral Hypothalamus: A Connection Between Sleep Disorder and Epilepsy in the Kv1.1 Knock-Out Mouse. American Epilepsy Society, San Diego, CA, December, 2012. 2012
• Ranade NP, Samson KK, Simeone KA, Simeone TA. Anticonvulsant Effects of Pioglitazone on High Potassium Seizure-Like Events in in vitro Hippocampal Slices. American Epilepsy Society, San Diego, CA, December, 2012. 2012
• Simeone TA. Carbamazepine inhibition of sharp wave-ripple complexes is associated with synapse specific effects on neurotransmission and short-term plasticity. Creighton University, The Faculty Club Research at Center Stage, October, 2012. 2012
• "High Frequency Oscillations and Epilepsy: the State of Our Knowledge" Neurology Grand Rounds, CME credit, Creighton University School of Medicine, Omaha, NE, March 2012 2012
• Simeone TA, Simeone KA, Samson KK, Rho JM. Loss of Kv1.1 Alpha Subunit Alters Hippocampal Sharp Wave-Ripple Complexes and Promotes the Emergence of Pathologic Fast Ripples. American Epilepsy Society, Baltimore, MD. 2011
• 2. Simeone KA, Roundtree HM, Samson KK, Simeone TA. Pathologic Hypocretin Circuitry: A Novel Mechanism of Sleep Disorders Associated with Epilepsy in Kv1.1 Knock-Out Mice. American Epilepsy Society, Baltimore, MD. 2011
• Normal Emergent Properties Hijacked by an Epileptic Brain. St. Albert's Day, Creighton University School of Medicine 2011
• 1. Simeone TA. Carbamazepine inhibition of sharp wave-ripple complexes is associated with synapse specific effects on neurotransmission and short-term plasticity. American Epilepsy Society, San Antonio, TX 2010
• UNL Department of Biochemistry & Redox Biology Center. "Epilepsy and Emergent Properties of Neuronal Networks". 2010
• Normal Emergent Properties Hijacked by an Epileptic Brain. Faculty Club, Creighton University School of Medicine 2010
• "Epilepsy: dysregulation of emergent properties of neuronal networks." Dept of Pharmacology, UNMC, Omaha, NE 2010
• "Epilepsy: Dysregulation of Emergent Properties of Neuronal Networks," presented to the Molecular & Cellular Biology Faculty Research Group 2009

Awards

• Intramural Research Award
  Creighton University School of Medicine New Investigator Award