Mechanisms of neurite outgrowth and identification of potential neurotrophic agents that could induce neuronal differentiation and neurite outgrowth conferring therapeutic protection against neurodegenerative diseases. Also, development of new formulations and novel drug delivery techniques to improve the ocular bioavailability of poorly permeating drugs that may play an important role in treatment of ocular infections and retinal diseases.
Neural Regeneration Research Hernandez, C, Shukla, S Liposome Based Drug Delivery for Treatment of Alzheimer’s Disease 17(6), p. 1190-1198 2022
Pharmaceuticals Cho, H, Shukla, S Role of Edaravone as a Treatment Option for Patients with Amyotrophic Lateral Sclerosis 14(1), p. 29 2021
Frontiers in Pharmacology Shukla, S., Tekwani, B. L. Histone Deacetylases Inhibitors in Neurodegenerative Diseases, Neuroprotection and Neuronal Differentiation 11(537) 2020
Journal of Pharmaceutical Sciences Janga, K. Y., Tatke, A., Shukla, S., Lamichhane, S. P., Avula, B., Wang, X., Majumdar, S. Retina Compatible Interactions and Effective Modulation of Blood Ocular Barrier P-gp Activity by Third-Generation Inhibitors Improve the Ocular Penetration of Loperamide 107(8), p. 2128-2135 2018
Chaurasiya, N.D., Shukla, S., & Tekwani, B.L. A combination in Vitro Assay for Evaluation of Neurotrophic Activity and Cytotoxicity. SALS DISCOVERY: Advancing the Science of Drug Discovery. 22(6), p. 667-675 2017
Shukla, S., Shariat-Madar, Z., Walker, L.A., & Tekwani, B.L. Mechanism for neurotrophic action of vorinostat, a pan histone deacetylase inhibitor. Molecular and Cellular Neuroscience 77, p. 11-20 2016
Nayak, S.K., Swain, P., Nanda, P.K., Dash, S., Shukla, S., Meher, P.K, & Maiti, N.K. Effect of endotoxin on the immunity of Indian major carp, Labeo rohita. Fish & Sellfish Immunology 24(4), p. 394-399 2007
Presentations
Surabhi Shukla and Babu Lal Tekwani: Role of Cyclic AMP in Suberoylanilide Hydroxamic Acid (SAHA) Induced Neurite Outgrowth, AAPS PharmSci 360 meeting, San Antonio, Texas. 2019
Karthik Yadav Janga, Akshaya Tatke, Surabhi Shukla, Soumyajit Majumdar. Inhibition of Mrp1 Efflux Protein Activity at the Blood Ocular Barriers: Effect of Specific Inhibitor on Ocular Penetration of Fluorescein, AAPS Annual Meeting, San Diego, California 2017
Karthik Yadav Janga, Akshaya Tatke, Surabhi Shukla, Bharathi Avula, Soumyajit Majumdar. The Impact of P-gp on the Blood Ocular Transport of Paclitaxel: A comparative study using Wild Type and Mdr 1A Knock Out Sprague Dawley Rats. AAPS Annual Meeting, San Diego, California. 2017
Karthik Yadav Janga, Akshaya Tatke, Surabhi Shukla, Bharathi Avula, Soumyajit Majumdar. Improved Permeation of Paclitaxel Across the Blood Aqueous Barrier by Modulating P-gp Activity Using Specific Inhibitors. (2017) AAPS Annual meeting, Sand Diego, CA. 2017