Sonia Maria Rocha-Sanchez, BS, MS, PhD, MBA

Department

Oral Biology

Position

Professor

Publications

• Journal of medicinal chemistry
  Bhattarai Pankaj, Structural Determinants of Indole-2-carboxamides: Identification of Lead Acetamides with Pan Antimycobacterial Activity
  66:1, p. 170 - 187 2023
• Oral surgery, oral medicine, oral pathology and oral radiology
  Benn Douglas K., A radiographic method for distinguishing noncavitated from cavitated proximal carious lesions
  132:6, p. 715 - 726 2021
• Scientific Reports
  Tarang Shikha, In silico Design of a Multivalent Vaccine Against Candida albicans
  10:1 2020
• Hearing Research
  Tarang Shikha, Spatiotemporally controlled overexpression of cyclin D1 triggers generation of supernumerary cells in the postnatal mouse inner ear
  390 2020
• Scientific reports
  Rocha-Sanchez Sonia M., Quinoxaline protects zebrafish lateral line hair cells from cisplatin and aminoglycosides damage (vol 8, 15119, 2018)
  9 2019
• Journal of Visualized Experiments
  Tarang Shikha, Inducible and reversible dominant-negative (DN) protein inhibition
  2019:143 2019
• Scientific Reports
  Weston Michael D., A mouse model of MIR-96, MIR-182 and MIR-183 misexpression implicates MIRNAs in cochlear cell fate and homeostasis
  8:1 2018
• Frontiers in Cellular Neuroscience
  Tarang Shikha, Generation of a Retinoblastoma (Rb)1-inducible dominant-negative (DN) mouse model
  9, p. 52 2015
• Journal of behavioral and brain science
  Rocha-Sanchez Sonia M., Lack of Rbl1/p107 Effects on Cell Proliferation and Maturation in the Inner Ear
  3:7, p. 534 - 555 2013
• Journal of Neuroscience
  Lv Ping, Posthearing Ca2+ currents and their roles in shaping the different modes of firing of spiral ganglion neurons
  32:46, p. 16314 - 16330 2012
• Indian Journal of Human Genetics
  Barritt Laura C., Conditional deletion of the human ortholog gene Dicer1 in Pax2-Cre expression domain impairs orofacial development
  18:3, p. 310 - 319 2012
• Physiological Entomology
  Montiel Eugenia E., Nucleolus size varies with sex, ploidy and gene dosage in insects
  37:2, p. 145 - 152 2012
• Developmental Dynamics
  Weston Michael D., MicroRNA-183 family expression in hair cell development and requirement of microRNAs for hair cell maintenance and survival
  240:4, p. 808 - 819 2011
• Journal of Neuroscience
  Rocha-Sanchez Sonia M., Mature mice lacking Rbl2/p130 gene have supernumerary inner ear hair cells and supporting cells
  31:24, p. 8883 - 8893 2011
• BMC Developmental Biology
  Sciarretta Carla, PLCγ-activated signalling is essential for TrkB mediated sensory neuron structural plasticity
  10 2010
• Brain Research
  Rocha-Sanchez Sonia M., Developmental expression of Kcnq4 in vestibular neurons and neurosensory epithelia
  1139, p. 117 - 125 2007
• Journal of Biomedical Optics
  Tiede Leann M., Determination of hair cell metabolic state in isolated cochlear preparations by two-photon microscopy
  12:2 2007
• Gene
  Beisel Kirk W., Diversity of Ca2+-activated K+ channel transcripts in inner ear hair cells
  386:1-2, p. 11 - 23 2007
• International Journal of Developmental Biology
  Rocha-Sanchez Sonia M., Pocket proteins and cell cycle regulation in inner ear development
  51:6-7, p. 585 - 595 2007
• Brain Research
  Weston Michael D., MicroRNA gene expression in the mouse inner ear
  1111:1, p. 95 - 104 2006
• Journal of Neuroscience
  Beisel Kirk W., Differential expression of KCNQ4 in inner hair cells and sensory neurons is the basis of progressive high-frequency hearing loss
  25:40, p. 9285 - 9293 2005
• Cytogenetic and Genome Research
  Rocha-Sanchez Sonia M., Imitate to integrate: Reviewing the pathway for B chromosome integration in Trypoxylon (Trypargilum) albitarse (Hymenoptera, Sphecidae)
  106:2-4, p. 398 - 401 2004
• Journal of Medical Genetics
  Shen Hui, A genome-wide linkage scan for bone mineral density in an extended sample: evidence for linkage on 11q23 and Xq27
  41:10, p. 743 - 751 2004
• BMC Genetics
  Dvornyk Volodymyr, Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis
  5, p. 4 2004
• Current Molecular Medicine
  Liu Yong-Jun, Molecular and genetic mechanisms of obesity: Implications for future management
  3:4, p. 325 - 340 2003
• Proceedings of the Royal Society B: Biological Sciences
  Araújo S. M.S.R., Integration of a B chromosome into the A genome of a wasp, revisited
  269:1499, p. 1475 - 1478 2002
• Chromosome Research
  Araújo S. M.S.R., Genetic load caused by variation in the amount of rDNA in a wasp
  10:7, p. 607 - 613 2002
• Proceedings of the Royal Society B: Biological Sciences
  Araújo S. M.S.R., Integration of a B chromosome into the A genome of a wasp
  268:1472, p. 1127 - 1131 2001
• Cytobios
  Araújo Sônia M.S.R., The B chromosome system of Trypoxylon (Trypargilum) albitarse (Hymenoptera, Sphecidae) 1. Banding analysis
  2000:396, p. 7 - 13 2000

Presentations

• Panel Discussion: Safe and Sound - Biological, Cultural, and Social Aspects of Hearing Impairment 2016
• Therapeutic prospects of Atoh1 Gene Therapy for Hair Cell Regeneration Where do we stand? Creighton University School of Medicine, Department of Biomedical Sciences. May 1st, 2015. 2015
• Puetz III, W.J., Barritt L.C., Kum J.M., Rocha-Sanchez S.M., Tarang S., Okane B.J. (2015) TREM-1 and TREM-2 protein expression in normal and healthy human gingival tissue. 2015 AACA Annual Meeting, Henderson, NV. 2015
• Therapeutic prospects for treating and rescuing lost hearing. Boys Town National Research Hospital (BTNRH). December 16th, 2014. 2014
• Reversible Inactivation of the Retinoblastoma 1 (Rb1) Gene: What does it mean for hair cell proliferation? University of Nebraska Medical center, November 11th, 2014. 2014
• Berry M.R., Rocha-Sanchez S.M., Benn D.K. (2014) Determining the difference between active and inactive white spot lesions using Sodium Iodide. Creighton University St. Alberts Research Day. Omaha, NE 2014
• Tarang S., Gurumurthy C., Rocha-Sanchez S.M. (2014) Characterization of a novel Rb1 inducible dominant-negative mouse model. 37th ARO Mid-Winter Meeting. San Diego, CA. 2014
• Rocha-Sanchez S.M., Kum J., Zhang Q., Wagner K-U (2014) Temporally Controlled Inactivation of the Retinoblastoma Family of Proteins in the Auditory Supporting Cells. 37th ARO Mid-Winter Meeting. San Diego, CA. 2014
• Brechon M.L., Rocha-Sanchez S.M., Benn D.K. (2013) Pilot Study: Can the presence of calculus in occlusal fissures influence the radiographic detection of caries? 19th International congress of Dentomaxillofacial Radiology (IADMFR). Bergen, Norway. 2013
• McGee J., Brunette K., Stimmler S., Filippini K., Rocha-Sanchez S., Walsh E. (2013) Mechanical filters in Rbl2 null mice: The influence of supernumerary inner ear sensory and/or support cells. 36th ARO Mid-Winter Meeting. Baltimore, MD. 2013
• Brunette K, McGee J, Rocha-Sanchez S, Stimmler S, Walsh E (2013) Do supernumerary sensory cells in the cochleae of Rbl2 null mice provide protection from noise-induced trauma? 36th ARO Mid- Winter Meeting. Baltimore, MD. 2013
• Conditional Deletion of Dicer Impairs Orofacial Development. IADR/LAR General Session. Iguassu Falls, Brazil. June 20th 23, 2012. Podium Presentation 2012
• Rocha-Sanchez, S.M., Miller, J.M., Barritt, L., Scheetz, L., Pierce, M.L., Soukup, G. (2012) Conditional Deletion of Dicer Impairs Orofacial Development. Abstract #19. 90th General Session & Exhibition of the IADR, Iguacu Fall, Brazil. 2012
• Scheetz L, Mighell T, Smith L., Walsh E, McGee J., Rocha-Sanchez S.M. (2012) Lack of the Retinoblastoma Like-1 (p107) Gene Affects Organ of Corti Proliferation, Maturation and Homeostasis. 35th ARO Mid-Winter Meeting. San Diego, CA. 2012
• Hegner E., McGee J., Rocha-Sanchez S.M., Walsh E. (2012) What Tuning Curves from Rbl2 Mutant Mice Reveal about the Influence of Supernumerary Sensory and Support Cells on the Mechanics of Inner-Ear Transduction. 35th ARO Mid-Winter Meeting. San Diego, CA. 2012
• Cochlear Hair Cell Regeneration through Cell Cycle Manipulation. NIDCD Workshop on Regenerative therapies. Bethesda, MD. September 14, 2011. Invited Speaker 2011
• Quantitative Manipulation of Pocket Proteins in Cochlear Supporting Cells to mediate Hair Cell Regeneration. NIH/NICRR/UNMC/COBRE External Advisory Committee Meeting. Omaha, NE. April 1, 2011. 2011
• Wilkinson T.G., Rocha-Sanchez S.M., Nunn M., Benn D.K. (2011) Sodium Iodide radiographic contrast to differentiate between non- and cavitated carious lesions. Abstract# 80. 62nd AAOMR. Chicago, IL. Taylor poster and presentation won 1st place. 2011
• Rocha-Sanchez, S.M., Scheetz, L.R., Siddiqi S., Mighell T.L. (2011) Pocket Proteins sound off: The retinoblastoma gene family in the inner ear sensory hair cells regeneration. Abstract# 50. 2nd Rb Meeting. Toronto, ON, Canada. 2011
• Cerutis D. R., McLaughlin M., Rocha-Sanchez S.M., McVaney T.P., Ogunleye A., Heanden K.V., and Parrish L.C. (2011) Lysophosphatidic Acid Receptors, Periodontal Disease, and Type 2 Diabetes. NMRI Midwest Regional Workshop. Omaha, NE. 2011
• George M., Rocha-Sanchez S.M., Scheetz L., Nayak G., Legan K., Richardson G., Band H. (2011) Expression and Localization of EHD Proteins in the Mouse Cochlea. Abstract# 822. 34th ARO Mid- Winter Meeting. Baltimore, MD. 2011
• Scheetz L., Weston M., Rocha-Sanchez S. M. (2011) Deletion of the Retinoblastoma Gene Rbl2/p130 Is Associated with Transcriptional Changes in the Expression of Mitotic-, Cell Growth-, and Differentiation Regulators in the Mouse Organ of Corti. Abstract# 843. 34th ARO Mid-Winter Meeting. Baltimore, MD. 2011
• Rocha-Sanchez S.M., Scheetz L., Contreras M., Weston M., Korte M., Walsh E., McGee J. (2011) Mature Rbl2/p130-Deficient Mice Inner Ear Is Functional Despite the Presence of Additional Hair Cells and Supporting Cells. Abstract# 842. 34th ARO Mid-Winter Meeting. Baltimore, MD. 2011
• Hegner E, McGee J, Rocha-Sanchez S.M., Walsh E. (2011) What Tuning Curves from Rbl2 Mutant Mice Reveal About the Influence of Supernumerary Sensory and Support Cells on the Mechanics of Inner-Ear Transduction. Abstract# 841. 34th ARO Mid-Winter Meeting. Baltimore, MD. 2011
• Weston M., Rocha-Sanchez S.M., Pierce M., Soukup G. (2011) Increased Cochlear Inner Hair Cells in Transgenic MicroRNA-183 Family Misexpression Mice Implicate MicroRNA Mediation of HairSonia M. Rocha-Sanchez, M.S., Ph.D. Cell and Supporting Cell Proliferation, Differentiation and Survival. Abstract# 826. 34th ARO Mid- Winter Meeting. Baltimore, MD. 2011
• Pierce M., Weston M., Jensen-Smith H., Walsh E., McGee J., Korte M., Fritzsch B, Rocha-Sanchez S.M., Soukup G. (2011) Hair Cell MicroRNA Depletion Affects Hair Cell Maintenance and Causes Progressive Hearing Loss. Abstract# 824. 34th ARO Mid-Winter Meeting. Baltimore, MD. 2011
• Gardener K.B., Barritt L.C., Sheetz L.R., and Rocha-Sanchez S.M. (2011) Histological Analysis of Cranioskeletal Development in a Conditional Dicer Knockout Mouse. 2011 Midwest Student Biomedical Science Research Conference. Omaha, NE. Kelsey Gardners poster was selected for presentation at th e 47th Annual Dental Students Conference On Research that took place in Gaithersburg, MD this past May, 2011. 2011
• Role of Dicer in Craniofacial Development. Department of Oral Biology, University of Nebraska Medical Center, School of Dentistry, Lincoln, NE. December 8, 2010. Invited Speaker 2010
• Digging Deeper in the Cell Cycles Pocket: The Retinoblastoma Gene Family in Auditory Hair Cells Regeneration. Department of Biomedical Sciences, Creighton University School of Medicine, Omaha NE. November 30, 2010. Invited Speaker at BMS 791 Biomedical Science Seminars 2010
• Role of MicroRNA (miRNA) in mammalian orofacial development. 88th General Session & Exhibition of the IADR, Barcelona, Spain. July 14, 2010. Podium Presentation 2010
• Little siblings with a big attitude: Rbl1(p107) and Rbl2 (p130) in inner ear hair cell regeneration. 33rd ARO Mid-Winter Meeting, Anaheim, CA. February 20, 2010. Podium Presentation 2010
• Rocha-Sanchez S.M., Scheetz L., Weston M., McGee J., Walsh E. (2010) Little Siblings with a Big Attitude: Rbl1 (P107) and Rbl2 (P130) in Inner Ear Hair Cell Regeneration. Abstract# 13. 33rd ARO Mid-Winter Meeting. Anaheim, CA. 2010
• Rocha-Sanchez S.M., Scheetz L., Weston M., McGee J., Walsh E. (2010) Rbl1 (p107) and Rbl2 (p130) in Inner Ear Hair Cell Regeneration. Abstract# S100. NIH, NCRR third Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE). Washington, DC. 2010
• Pierce M., Weston M., Walsh E., McGee J., Korte M., Jensen-Smith H., Fritzsch B, Rocha-Sanchez S.M., Soukup G. (2010) Hair Cell-Specific MicroRNA Depletion Affects Hair Cell Maintenance and Causes Progressive Hearing Loss. Abstract# 590. 33rd ARO Mid-Winter Meeting. Anaheim, CA. 2010
• Joseph M. Miller, Laura Barritt, Laura Scheetz, L. Pierce, Garrett A. Soukup, and Sonia M. Rocha- Sanchez (2010). Role of MicroRNA (miRNA) in mammalian orofacial development. Abstract #17. 88th General Session & Exhibition of the IADR, Barcelona, Spain. 2010

Other

• Pharmacologic Regulation of Auditory Hair Cell Regeneration

• School of Dentistry Lab Equipment

• Pharmacologic Regulation of Auditory Hair Cell Regeneration

• School of Dentistry Lab Equipment

Awards

• PhD Fellowship
  Brazilian Science Foundation (CNPq/CAPES)