Gwendalyn King, PhD

Department

Biology

Position

Associate Professor

Articles

• King Gwendalyn, Klotho MAb 2014
• King Gwendalyn D., Puntel Mariana, Muhammad A. K.M.Ghulam, Xiong Weidong, Kroeger Kurt M., Larocque Daniel, Palmer Donna, Ng Philip, Lowenstein Pedro R., Castro Maria G., High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity (Journal of Virology (2008) 82, 9, (4680-4684)) 2008

Publications

• Cell reports (Cambridge)
  Gonzalez Jose Carlos, Goode Lacy K., Lee Haeun, Vincent Angela M., Hill Angela L., King Gwendalyn D., Gamble Karen L., Wadiche Jacques I., Overstreet-Wadiche Linda, Circadian regulation of dentate gyrus excitability mediated by G-protein signaling
  42:2, p. 112039 - 112039 2023
• Frontiers in Medicine
  Garth Jaleesa, Faul Christian, Barnes Jarrod W., Salathe Matthias, Krick Stefanie, Easter Molly, Skylar Harris Elex, Sailland Juliette, Kuenzi Lisa, Chung Samuel, Dennis John S., Baumlin Nathalie, Adewale Adegboyega T., Rowe Steven M., King Gwendalyn, The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance
  6 2020
• JCI insight
  Xiao Zhousheng, King Gwendalyn, Mancarella Salvatore, Cao Li, Cai Chun, Quarles Leigh Darryl, Munkhsaikhan Undral, FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model
  4:23 2019
• Journal of molecular cell biology
  Shah Kushani, King Gwendalyn D., Jiang Hao, A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells
  12:1, p. 4 - 16 2019
• Molecular and Cellular Neuroscience
  Vo Hai T., Phillips Mary L., Herskowitz Jeremy H., King Gwendalyn D., Klotho deficiency affects the spine morphology and network synchronization of neurons
  98, p. 1 - 11 2019
• eNeuro
  Laszczyk Ann M., Fox Stephanie, Nettles Dailey, Pollock Tate A., Garcia Melissa L., Wang Jing, Darryl Quarles L., King Gwendalyn D., FGF-23 deficiency impairs hippocampal-Dependent cognitive function
  6:2 2019
• American Journal of Physiology - Lung Cellular and Molecular Physiology
  Barnes Jarrod W., Locy Morgan, Helton Scott, Hutcheson Samuel, Kurundkar Deepali, Logsdon Naomi J., Garth Jaleesa, Denson Rebecca, Farver Carol, Vo Hai T., King Gwendalyn, Matalon Sadis, Duncan Dawn, Kentrup Dominik, Faul Christian, Kulkarni Tejaswini, De Andrade Joao A., Yu Zhihong, Thannickal Victor J., Krick Stefanie, Role of fibroblast growth factor 23 and klotho cross talk in idiopathic pulmonary fibrosis
  317:1, p. L141 - L154 2019
• Brain plasticity (Amsterdam, Netherlands)
  Vo Hai T, Laszczyk Ann M, King Gwendalyn D, Klotho, the Key to Healthy Brain Aging?
  3:2, p. 183 - 194 2018
• European Respiratory Journal
  Krick Stefanie, Russell Derek W., Helton Scott, Grosche Astrid, Sailland Juliette, Geraghty Patrick, Viera Liliana, Wells J. Michael, Xu Xin, Gaggar Amit, Barnes Jarrod, King Gwendalyn D., Campos Michael, Faul Christian, Salathe Matthias, Yanucil Christopher, Grabner Alexander, Baumlin Nathalie, Fibroblast growth factor 23 and Klotho contribute to airway inflammation
  52:1 2018
• Journal of the American Society of Nephrology : JASN
  Han Xiaobin, Pi Min, Ross Jed, Kolumam Ganesh, Sonoda Junichiro, King Gwendalyn, Darryl Quarles L., Cardiovascular effects of renal distal tubule deletion of the fgf receptor 1 gene
  29:1, p. 69 - 80 2018
• Scientific Reports
  Krick Stefanie, Aller Sheyla Paredes, Aguiar Carolina, Grabner Alexander, Sailland Juliette, David Nicolae V., Baumlin Nathalie, Mendes Eliana, Schmid Andreas, Qi Lixin, Geraghty Patrick, King Gwendalyn, Birket Susan E., Rowe Steven M., Faul Christian, Salathe Matthias, Klotho Inhibits Interleukin-8 Secretion from Cystic Fibrosis Airway Epithelia
  7:1 2017
• Neurobiology of Aging
  Laszczyk Ann M., Fox-Quick Stephanie, Vo Hai T., Nettles Dailey, Pugh Phyllis C., Overstreet-Wadiche Linda, King Gwendalyn D., Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss
  59, p. 41 - 54 2017
• Neuroscience
  Li Qin, Vo Hai T., King Gwendalyn D., Wang Jing, Fox-Quick Stephanie, Dobrunz Lynn E., Klotho regulates CA1 hippocampal synaptic plasticity
  347, p. 123 - 133 2017
• eLife
  Adlaf Elena W., Vo Hai T., Onyilo Vincent C., Araujo Matheus T., Dieni Cristina V., King Gwendalyn D., Wadiche Jacques I., Overstreet-Wadiche Linda, Vaden Ryan J., Niver Anastasia J., Manuel Allison F., Adult-born neurons modify excitatory synaptic transmission to existing neurons
  6 2017
• American Journal of Hypertension
  Liu Xue, Zhao Tieqiang, Chen Yuanjian, Mccoy Cody W., Quarles Darryl L., Pi Min, Bhattacharya Syamal K., King Gwendalyn, Sun Yao, Differential regulatory role of soluble klothos on cardiac fibrogenesis in hypertension
  29:10, p. 1140 - 1147 2016
• PloS one
  Han Xiaobin, Huang Jinsong, Yang Jiancheng, Li Linqiang, King Gwendalyn, Quarles L. Darryl, Conditional deletion of Fgfr1 in the proximal and distal tubule identifies distinct roles in phosphate and calcium transport
  11:2 2016
• FEBS Letters
  Han Xiaobin, King Gwendalyn, Li Linqiang, Yang Jiancheng, Xiao Zhousheng, Quarles Leigh Darryl, Counter-regulatory paracrine actions of FGF-23 and 1,25(OH)2D in macrophages
  590:1, p. 53 - 67 2016
• PLoS genetics
  Watson Jennifer A., Siegal Gene P., Wilson Julie A., Icyuz Mert, Howard Alan D., Phillips Edward, DeSilva Tara M., Bean Andrew J., King Gwendalyn D., Phillips Scott E., Bhattacharyya Bula J., Vaden Jada H., Miller Richard J., Wilson Scott M., Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS
  11:6 2015
• Molecular Neurodegeneration
  Vaden Jada H., Phillips Scott E., Bhattacharyya Bula J., Chen Ping Chung, Watson Jennifer A., Marshall Andrea G., Wilson Julie A., King Gwendalyn D., Miller Richard J., Wilson Scott M., Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
  10:1 2015
• Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  Maltare Astha, Dunn Taylor S., Ballestas Mary E., Accavitti-Loper Mary Ann, King Gwendalyn D., Laszczyk Ann M., Nietz Angela K., Development and characterization of monoclonal antibodies to detect Klotho
  33:6, p. 420 - 427 2014
• Age
  Mehi Stephen J., Maltare Astha, Abraham Carmela R., King Gwendalyn D., MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro
  36:1, p. 141 - 149 2014
• Journal of Biological Chemistry
  Zhou Tracey B.Tucker, Abraham Carmela R., King Gwendalyn D., Chen Ci Di, Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk
  288:51, p. 36302 - 36311 2013
• Brain Research
  Clinton Sarah M., Maltare Astha, Glover Matthew E., Laszczyk Ann M., Mehi Stephen J., Simmons Rebecca K., King Gwendalyn D., Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood
  1527, p. 1 - 14 2013
• Investigative Ophthalmology and Visual Science
  Reish Nicholas J., Laszczyk Ann M., Maltare Astha, McKeown Alex S., Kraft Timothy W., Gross Alecia K., King Gwendalyn D., The age-regulating protein klotho is vital to sustain retinal function
  54:10, p. 6675 - 6685 2013
• Age
  King Gwendalyn D., Rosene Douglas L., Abraham Carmela R., Promoter methylation and age-related downregulation of Klotho in rhesus monkey
  34:6, p. 1405 - 1419 2012
• Neoplasia
  Candolfi Marianela, King Gwendalyn D., Yagiz Kader, Foulad David, Kroeger Kurt M., Barnett Nick, Josien Regis, Lowenstein Pedro R., Curtin James F., Mineharu Yohei, Ghulam Muhammad A. K.M., Castro Maria G., Plasmacytoid dendritic cells in the tumor microenvironment
  14:8, p. 757 - 770 2012
• Biochemical Journal
  King Gwendalyn D., Zeldich Ella, Chen Ci Di, Huang Mickey M., Brazee Patricia L., Schuman Eli R., Robin Maxime, Cuny Gregory D., Glicksman Marcie A., Abraham Carmela R., Identification of novel small molecules that elevate Klotho expression
  441:1, p. 453 - 461 2012
• American Journal of Neurodegenerative Diseases
  So Pauline P.L., Zeldich Ella, Seyb Kathleen I., Chen Ci Di, Huang Mickey M., Concannon John B., King Gwendalyn D., Cuny Gregory D., Glicksman Marcie A., Abraham Carmela R., Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization
  1:1, p. 75 - 87 2012
• Molecular Therapy
  King Gwendalyn D., Kroeger Kurt M., Muhammad A. K.M.Ghulam, Larocque Daniel, Kelson Kyle R., Xiong Weidong, Liu Chunyan, Sanderson Nicholas S.R., Castro Maria G., Lowenstein Pedro R., Combined Flt3L/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen
  19:10, p. 1793 - 1801 2011
• Clinical Cancer Research
  Mineharu Yohei, King Gwendalyn D., Muhammad Akm G., Bannykh Serguei, Castro Maria G., Kroeger Kurt M., Liu Chunyan, Lowenstein Pedro R., Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination
  17:14, p. 4705 - 4718 2011
• Current Gene Therapy
  Castro Maria G., Yagiz Kader, Candolfi Marianela, Kroeger Kurt M., King Gwendalyn D., Curtin James F., Mineharu Yohei, Assi Hikmat, Wibowo Mia, Muhammad A. Ghulam, Foulad David, Puntel Mariana, Lowenstein Pedro R., Gene therapy and targeted toxins for glioma
  11:3, p. 155 - 180 2011
• Cancer research (Chicago, Ill.)
  Candolfi MARIANELA, Yagiz Kader, Foulad David, Barnett Nicholas, Kroeger Kurt M., Lowenstein Pedro R., Castro Maria G., Mineharu Yohei, Balasubramanian Karthika, Puntel Mariana, King Gwendalyn D., Muhammad AKM G., Abstract 467: Circulating DNA released from brain tumors in response to conditional cytotoxic/immune stimulatory gene therapy induces activation of TLR9 on pDCs, leading to antitumor immunity
  71:8_Supplement, p. 467 - 467 2011
• Alzheimer's & dementia
  Abraham Carmela R., Chen Ci-Di, King Gwendalyn D., P3‐469: Development of Klotho enhancers as novel therapeutics for Alzheimer's disease
  6:4S_Part_19, p. S591 - S591 2010
• Journal of clinical oncology
  Lowenstein P. R., Assi H., Yagiz K., King G., Candolfi M., Xiong W., Kroeger K., Bannykh S., Castro M., Mineharu Y., Comparison of intratumoral loading of Flt3L/TK-recruited dendritic cells and systemic vaccination with tumor-lysate loaded dendritic cells in the stringent syngeneic CNS1 rat glioma model: Effect of temozolomide on anti-glioma immunity
  28:15_suppl, p. 2093 - 2093 2010
• Clinical Cancer Research
  Muhammad A. K.M.Ghulam, Candolfi Marianela, King Gwendalyn D., Yagiz Kader, Foulad David, Mineharu Yohei, Van Rooijen Nico, Sanderson Nicholas S., Yang Jieping, Khayznikov Maksim, Lowenstein Pedro R., Castro Maria G., Kroeger Kurt M., Treuer Katherine A., Nichols W. Stephen, Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy
  15:19, p. 6113 - 6127 2009
• Clinical Cancer Research
  Candolfi Marianela, Alzadeh Gabrielle E., Yagiz Kader, Foulad David, Tesarfreund Matthew, Liu Chunyan, Muhammad A. K.M.Ghulam, Puntel Mariana, Kroeger Kurtm, Lee Sharon, Curtin James F., King Gwendalyn D., Xiong Weidong, Lerner Jonathan, Sato Katsuaki, Mineharu Yohei, Lowenstein Pedro R., Castro Maria G., Release of HMGB1 in response to proapoptotic glioma killing strategies
  15:13, p. 4401 - 4414 2009
• Alzheimer's & dementia
  King Gwendalyn D., Abraham Carmela R., Chen Ci-Di, Podvin Sonia, P4‐186: Modulating Klotho expression to protect against age‐induced neurodegeneration
  4:4S_Part_22, p. T725 - T726 2008
• Journal of Virology
  King Gwendalyn D., Castro Maria G., Xiong Weidong, Kroeger Kurt M., Puntel Mariana, Larocque Daniel, Palmer Donna, Ng Philip, Lowenstein Pedro R., Muhammad A. K.M.Ghulam, High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity
  82:9, p. 4680 - 4684 2008
• Molecular Therapy
  King Gwendalyn D., Kroeger Kurt M., Bresee Catherine J., Candolfi Marianela, Liu Chunyan, Manalo Charlene M., Muhammad A. K.M.Ghulam, Pechnick Robert N., Lowenstein Pedro R., Castro Maria G., Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits
  16:4, p. 682 - 690 2008
• The FASEB journal
  Muhammad A.K.M Ghulam, King Gwendalyn D., Candolfi Marianela, Curtin James, Liu Chunyan, Kroeger Kurt, Lowenstein Pedro R., Castro Maria G., Systemic Flt3L and intratumoral HSV1‐TK treatment eradicates intracranial GBM in a syngeneic model
  22:S1 2008
• The FASEB journal
  Candolfi Marianela, Muhammad AKM G, King Gwendalyn D, Puntel Mariana, Foulad David, Lerner Jonathan, Kroeger Kurt M, Liu Chunyan, Ahlsadeh Gabrielle E, Lee Sharon, Sato Katsuaki, Lowenstein Pedro R, Castro Maria G, Evaluation of proapototic transgenes to use in combination with Flt3L in an immune‐stimulatory gene therapy approach for Glioblastoma multiforme (GBM)
  22:S1 2008
• The FASEB journal
  King Gwendalyn D., Candolfi Marianela, Muhammad Ghulam, Larocque Daniel, Van Rooijen Nico, Bergeron Josee, Liu Chunyan, Kroeger Kurt, Lowenstein Pedro R., Castro Maria G., Overcoming brain immune privilege with Flt3L and TK treatment in a recurrent rat glioma model
  22:S1 2008
• The FASEB journal
  Candolfi Marianela, King Gwendalyn D, Muhammad AKM G, Curtin James F, Castro Maria G, Lowenstein Pedro R, Liu Chunyan, Kroeger Kurt M, In vivo tumor antigen phagocytosis and trafficking by macrophages and pDCs infiltrating intracranial glioblastomas (GBM) in rats treated with adenoviruses (Ads) expressing TK and Flt3L
  22:S1 2008
• Neuro-Oncology
  King Gwendalyn D., Candolfi Marianela, Ghulam Muhammad A. K.M., Curtin James F., Barcia Carlos, Puntel Mariana, Liu Chunyan, Honig Sarah B., Mondkar Sonali, Lowenstein Pedro R., Castro Maria G., Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model
  10:1, p. 19 - 31 2008
• Molecular Therapy
  Barcia Carlos, Rapaport Alison J., Jimenez-Dalmaroni Maximiliano, Kroeger Kurt M., Puntel Mariana, Larocque Daniel, King Gwendalyn D., Johnson Stephen A., Mondkar Sonali, Liu Chunyan, Xiong Weidong, Candolfi Marianela, Lowenstein Pedro R., Ng Philip, Palmer Donna, Castro Maria G., One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity
  15:12, p. 2154 - 2163 2007
• Journal of Neuro-Oncology
  Candolfi Marianela, Muhammad A. K.M.G., Curtin James F., Nichols W. Stephen, Castro Maria G., Lerner Jonathan, King Gwendalyn D., Lowenstein Pedro R., Pluhar G. Elizabeth, McNiel Elizabeth A., Ohlfest John R., Freese Andrew B., Moore Peter F., Intracranial glioblastoma models in preclinical neuro-oncology
  85:2, p. 133 - 148 2007
• Journal of Experimental Medicine
  Barcia Carlos, Boyer Olivier, Kupiec-Weglinski Jerzy, Klatzmann David, Castro Maria G., Lowenstein Pedro R., King Gwendalyn D., Thomas Clare E., Curtin James F., Wawrowsky Kolja, Candolfi Marianela, Xiong Wei Dong, Kroeger Kurt, Liu Chunyan, In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain
  203:9, p. 2095 - 2107 2006
• Molecular therapy
  Curtin James, King Gwendalyn, Candolfi Marianela, Arditi Moshe, Fakhouri Tamer, Liu Chunyan, Michelsen Kathrin, Comin-anduix Begonya, Ribas Antoni, Lowenstein Pedro, Castro Maria, 424. Myd88/TLR Signaling Is Required for Immunotherapy-Mediated Glioblastoma Regression
  13:S1, p. S163 - S163 2006
• Molecular therapy
  King Gwendalyn, Honig Sarah, Curtin James, Castro Maria, Lowenstein Pedro, Bresee Catherine, Liu Chunyan, Zirger Jeffery, Vanrooijen Nico, Ribas Antoni, Pechnick Robert, 621. Immunological Memory in a Syngeneic Model of Recurrent and Multifocal Glioblastoma
  13:S1, p. S239 - S239 2006
• Journal of Immunology
  Curtin James F., King Gwendalyn D., Barcia Carlos, Liu Chunyan, Hubert François X., Guillonneau Carole, Josien Régis, Anegon Ignacio, Lowenstein Pedro E., Castro Maria G., Fins-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain
  176:6, p. 3566 - 3577 2006
• Journal of Virology
  Xiong Weidong, Palmer Donna, Ng Philip, Lowenstein Pedro R., Castro Maria G., Goverdhana Shyam, Sciascia Sandra A., Candolfi Marianela, Zirger Jeffrey M., Barcia Carlos, Curtin James F., Liu Chunyan, Kroeger Kurt, Agadjanian Hasmik, Medina-Kauwe Lali, Jaita Gabriela, King Gwendalyn D., Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses
  80:1, p. 27 - 37 2006
• Current Gene Therapy
  King Gwendalyn D., Lowenstein Pedro R., Castro Maria G., Curtin James F., Kroeger Kurt, Candolfi Marianela, Gene therapy and targeted toxins for glioma
  5:6, p. 535 - 557 2005
• Cancer Research
  Ali Sumia, Lassmann Hans, Lowenstein Pedro R., Castro Maria G., Candolfi Marianela, King Gwendalyn D., Curtin James F., Xiong Weidong, Liu Chunyan, Puntel Mariana, Cheng Queng, Van Rooijen Nico, Prieto Jesus, Ribas Antoni, Kupiec-Weglinski Jerzy, Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model
  65:16, p. 7194 - 7204 2005
• Molecular Therapy
  Goverdhana S., Sciascia S. A., Mondkar S., King G. D., Hu J., Candolfi M., Greengold D. S., Lowenstein P. R., Castro M. G., Zirger J. M., Barcia C., Curtin J. F., Soffer E. B., Puntel M., Xiong W., Regulatable gene expression systems for gene therapy applications
  12:2, p. 189 - 211 2005
• Molecular therapy
  Xiong Weidong, Goverdhana Shyam, Curtin James, Barcia-gonzalez Carlos, Zirger Jeffrey, King Gwendalyn, Sciascia Sandra, Puntel Mariana, Candolfi Marianela, Palmer Donna, Ng Philip, Lowenstein Pedro, Castro Maria, 143. Regulated, High Capacity Adenoviral Vectors Mediated Long-Term Gene Expression in the Brain Even in the Presence of a Peripheral Immune Response to Adenovirus
  11:S1, p. S58 - S58 2005
• Molecular therapy
  Curtin James, King Gwendalyn, Xiong Weidong, Liu Chunyan, Lowenstein Pedror, Castro Mariag, 269. Stimulation of the Immune System Using Gene Therapy Is an Effective Approach for Treating Brain Tumors in Mouse and Rat Models
  11:S1, p. S106 - S106 2005
• Current Topics in Medicinal Chemistry
  Curtin James F., King Gwendalyn D., Candolfi Marianela, Greeno Remy B., Kroeger Kurt M., Lowenstein Pedro R., Castro Maria G., Combining cytotoxic and immune-mediated gene therapy to treat brain tumors
  5:12, p. 1151 - 1170 2005
• Molecular Therapy
  Ali Sumia, Curtin James F., Zirger Jeffrey M., Liu Chunyan, Xiong Weidong, King Gwendalyn D., Barcia Carlos, Puntel Mariana, Goverdhana Shyam, Lowenstein Pedro R., Castro Maria G., Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L)
  10:6, p. 1071 - 1084 2004
• Experimental Neurology
  King Gwendalyn D., Turner R. Scott, Adaptor protein interactions
  185:2, p. 208 - 219 2004
• Journal of Neurochemistry
  King Gwendalyn D., Cherian Kay, Turner R. Scott, X11α impairs γ- but not β-cleavage of amyloid precursor protein
  88:4, p. 971 - 982 2004
• Neuroscience
  King G. D., Perez R. G., Steinhilb M. L., Gaut J. R., Turner R. S., X11α modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein
  120:1, p. 143 - 154 2003

Grants

• INBRE: Effects of Klotho Deficiency on Adult Neurogenesis/Sponsor: University of Nebraska Medical Center/UNMC

• Regulation of Choroid Plexus Epithelial Function by Klotho/Sponsor: National Institutes of Health/NIH

• Newborn Neurons in the Adult Hippocampal Network/Sponsor: University of Alabama at Birmingham/UAB

• Klotho-Deficient Effects on Choroid Plexus Cells/Sponsor: Dr. George F. Haddix President's Faculty Research Grant

Awards

• Dean's Award for Professional Excellence: Major Advising
  CCAS Student Senate
• Robert F. Kennedy Memorial Award for Teaching Achievement
  Creighton Student Union
• Outstanding Service Award
  University of Alabama at Birmingham Graduate in Biomedical Sciences
• Graduate School Dean's Award for Excellence in Mentorship
  University of Alabama at Birmingham Graduate School