Jeremy M . Shefner, MD, PhD

Department

Neurology (Phoenix)

Position

Professor

Books

• Handbook of Clinical Neurology
  Andrews Jinsy A., Shefner Jeremy M., Clinical neurophysiology of anterior horn cell disorders [Book Chapter] 2019

Publications

• Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  Shefner Jeremy M., Malik Fady I., Meng Lisa, Rudnicki Stacy A., Wolff Andrew A., Andrews Jinsy A., Cockroft Bettina M., Cudkowicz Merit E., Hardiman Orla, Lee Jacqueline H., A phase III trial of tirasemtiv as a potential treatment for amyotrophic lateral sclerosis
  20:7-8, p. 584 - 594 2019
• Neurology
  Andrews Jinsy A., Bruijn Lucie I., Shefner Jeremy M., ALS drug development guidances and trial guidelines: Consensus and opportunities for alignment
  93:2, p. 66 - 71 2019
• Neurology
  Darras Basil T., Chiriboga Claudia A., Iannaccone Susan T., Swoboda Kathryn J., Montes Jacqueline, Mignon Laurence, Xia Shuting, Bennett C. Frank, Bishop Kathie M., Shefner Jeremy M., Gheuens Sarah, De Vivo Darryl C., Green Allison M., Sun Peng, Bhan Ishir, Schneider Eugene, Farwell Wildon, Nusinersen in later-onset spinal muscular atrophy: Long-term results from the phase 1/2 studies
  92:21, p. e2492 - e2506 2019
• Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  Rutkove Seward B., Qi Kristin, Liss Julie, Berisha Visar, Shefner Jeremy M., Shelton Kerisa, ALS longitudinal studies with frequent data collection at home: study design and baseline data
  20:1-2, p. 61 - 67 2019
• Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  Shefner Jeremy M., Rutkove Seward B., Caress James B., Benatar Michael, David William S., Cartwright Michael S., Macklin Eric A., Bohorquez Jose L., Reducing sample size requirements for future ALS clinical trials with a dedicated electrical impedance myography system
  19:7-8, p. 555 - 561 2018
• Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  Lechtzin Noah, Cudkowicz Merit E., Shefner Jeremy, Van den Berg Leonard H., Andrews Jinsy A., Genge Angela, Mitsumoto Hiroshi, Mora Jesus S., Hardiman Orla, de Carvalho Mamede, Respiratory measures in amyotrophic lateral sclerosis
  19:5-6, p. 321 - 330 2018
• European Journal of Neurology
  Smith R. A., Macklin E. A., Myers K. J., Pattee G. L., Goslin K. L., Meekins G. D., Green J. R., Shefner J. M., Pioro E. P., Assessment of bulbar function in amyotrophic lateral sclerosis: validation of a self-report scale (Center for Neurologic Study Bulbar Function Scale)
  25:7, p. 907 - e66 2018
• Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  Andrews Jinsy A., Cudkowicz Merit E., Hardiman Orla, Meng Lisa, Bian Amy, Lee Jacqueline, Wolff Andrew A., Malik Fady I., Shefner Jeremy M., VITALITY-ALS, a phase III trial of tirasemtiv, a selective fast skeletal muscle troponin activator, as a potential treatment for patients with amyotrophic lateral sclerosis: study design and baseline characteristics
  19:3-4, p. 259 - 266 2018
• Brooks Benjamin Rix, Jorgenson James A, Newhouse Barbara J, Shefner Jeremy M, Agnese Wendy, Edaravone in the treatment of amyotrophic lateral sclerosis: efficacy and access to therapy - a roundtable discussion 2018
• Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  Meng Lisa, Bian Amy, Jordan Scott, Wolff Andrew, Shefner Jeremy M., Andrews Jinsy, Profile of medical care costs in patients with amyotrophic lateral sclerosis in the Medicare programme and under commercial insurance
  19:1-2, p. 134 - 142 2018
• JAMA Neurology
  Andrews Jinsy A., Kulke Sarah F., Rudnicki Stacy A., Wolff Andrew A., Bozik Michael E., Malik Fady I., Shefner Jeremy M., Meng Lisa, Association Between Decline in Slow Vital Capacity and Respiratory Insufficiency, Use of Assisted Ventilation, Tracheostomy, or Death in Patients With Amyotrophic Lateral Sclerosis
  75:1, p. 58 - 58 2018

Presentations

• Invited Speaker, 2019 California ALS Summit, Irvine CA. 2019
• Invited Speaker, 2018 Northeast ALS Clinical Trials Consortium Annual Meeting, Clearwater FL. 2018
• Plenary Speaker, 2018 FightMND Australasion ALS Symposium, Melbourne, Australia. 2018
• Lisa Krivickas Lecturer, Massachusetts General Hospital, Boston, MA. 2018
• Invited Speaker, Packard Symposium on ALS, Baltimore, MD. 2017
• Grand Rounds, Houston Methodist Medical Center. 2017
• Grand Rounds, University of Arizona College of Medicine. 2017

Other

• Speech Analysis in ALS Patients with and without Cognitive Abnormalities: Evaluation of Sensitivity and Disease Progression

• Treat ALS NEALS Clinical Trials Network. Goal: to facilitate the performance of investigator initiated ALS trials.

• A Phase 2 study of CK107 in Patients with Amyotrophic Lateral Sclerosis (ALS) Goal: To determine the safety and preliminary efficacy of treatment of CK107 in ALS patients.

• Fluid Biomarkers with Deep Phenotyping in Patients with ALS. Goal: To discover fluid markers that correlate with specific aspects of decline in ALS patients.

• ALS AT HOME: Measuring ALS Progression using home based outcome measures. Goal: to reduce variability of standard outcome measures using frequent sampling and to test a paradigm whereby patients can participate in clinical trials remote from a study site.