Tal Teitz, PhD
Associate Professor
Pharmacology & Neuroscience
Contact
School of Medicine
Pharmacology and Neuroscience
Graduate School
Neuroscience (Master of Science)
CRISS III - Criss 3 - OFFICE 558B
Tal Teitz, PhD
Associate Professor
Pharmacology & Neuroscience
Our lab works on identifying and testing drugs for protection from chemotherapy-induced hearing loss. We utilize cell-based screens, cochlear explant cultures, and mouse models.
Cancer Research Area(s)
- Chemotherapy-Induced Toxicities
Curriculum Vitae
Research Focus
- Therapeutic intervention for chemotherapy-induced, noise-induced and age-related hearingloss.
- Function and protection of sensory cells in the mouse cochlea.
- Repurposing FDA-approved drugs for hearing loss and acute kidney injury caused by
cisplatin chemotherapy.
Department
Pharmacology and Neuroscience
Position
Associate Professor
Books
- Methods in Molecular Biology
Teitz Tal, Development of cell-based high-throughput chemical screens for protection against cisplatin-induced ototoxicity [Book Chapter] 2016
Articles
- Xu Heng, Erratum 2015
Publications
- Journal of the American Society of Nephrology
Pushpan Chithra K., Repurposing AZD5438 and Dabrafenib for Cisplatin-Induced Acute Kidney Injury 2023 - JCI insight
Ingersoll Matthew A, Dabrafenib protects from cisplatin-induced hearing loss in a clinically relevant mouse model 2023 - Journal of Medicinal Chemistry
Hazlitt Robert A., Development of Second-Generation CDK2 Inhibitors for the Prevention of Cisplatin-Induced Hearing Loss
61:17, p. 7700 - 7709 2018 - Journal of Experimental Medicine
Teitz Tal, CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss
215:4, p. 1187 - 1203 2018 - Nature genetics
Xu Heng, Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss
47:3, p. 263 - 266 2015 - Cancer Research
Teitz Tal, Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis
73:13, p. 4086 - 4097 2013 - PloS one
Teitz Tal, Preclinical models for Neuroblastoma
6:4 2011 - Cancer Research
Barbero Simone, Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis
69:9, p. 3755 - 3763 2009 - Cancer Research
Lahti Jill M., Does integrin-mediated cell death confer tissue tropism in metastasis?
66:12, p. 5981 - 5984 2006 - Cell Cycle
Teitz Tal, Halting neuroblastoma metastasis by controlling integrin-mediated death
5:7, p. 681 - 685 2006 - Nature
Stupack Dwayne G., Potentiation of neuroblastoma metastasis by loss of caspase-8
439:7072, p. 95 - 99 2006 - Nature medicine
Kidd Vincent J, Reply to 'Expression and methylation of CASP8 in neuroblastoma: Identification of a promoter region'
8:12, p. 1335 - 1335 2002 - Banelli Barbara, Expression and methylation of CASP8 in neuroblastoma 2002
- Oncogene
Teitz Tal, Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN
21:12, p. 1848 - 1858 2002 - Oncogene
Takita Junko, Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma
20:32, p. 4424 - 4432 2001 - Journal of Molecular Medicine
Teitz Tal, Aggressive childhood neuroblastomas do not express caspase-8
79:8, p. 428 - 436 2001 - Nature Medicine
Teitz Tal, Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN
6:5, p. 529 - 535 2000 - Seminars in Cell and Developmental Biology
Kidd Vincent J., Proteolytic regulation of apoptosis
11:3, p. 191 - 201 2000 - Medical and Pediatric Oncology
Takita Junko, Absent or reduced expression of the caspase 8 gene occurs frequently in neuroblastoma, but not commonly in Ewing sarcoma or rhabdomyosarcoma
35:6, p. 541 - 543 2000 - Gene
Grenet Jose, Structure and chromosome localization of the human CASP8 gene
226:2, p. 225 - 232 1999 - Proceedings of the National Academy of Sciences of the United States of America
Siegel D. S., Hexamethylene bisacetamide induces programmed cell death (apoptosis) and down-regulates BCL-2 expression in human myeloma cells
95:1, p. 162 - 166 1998 - Investigative and Cell Pathology
Teitz Tal, Thymic epithelial neoplasms in transgenic mice expressing SV40 T antigen under the control of an erythroid‐specific enhancer
177:3, p. 309 - 315 1995 - Carcinogenesis
Teitz T., Amplification of a sv40 t antigen transgene is associated with sarcomagenesis in mice
15:9, p. 2049 - 2051 1994 - DNA and Cell Biology
Teitz Tal, SV40 T Antigen Directed by a Powerful Erythroid Enhancer–Promoter Produced Sarcomas and Pancreatic Tumors But Not Erythroid-Specific Tumors in Transgenic Mice
13:7, p. 705 - 710 1994 - Proceedings of the National Academy of Sciences of the United States of America
Teitz T., Rhabdomyosarcoma arising in transgenic mice harboring the β-globin locus control region fused with simian virus 40 large T antigen gene
90:7, p. 2910 - 2914 1993 - Genomics
Yang-Feng Teresa L., Assignment of the human casein kinase II β-subunit gene to 6p12→p21
8:4, p. 741 - 742 1990 - Mutation Research - DNA Repair
Teitz Tal, Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells
236:1, p. 85 - 97 1990 - Gene
Teitz Tal, Isolation by polymerase chain reaction of a cDNA whose product partially complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells
87:2, p. 295 - 298 1990 - Proceedings of the National Academy of Sciences of the United States of America
Teitz T., Complementation of the UV-sensitive phenotype of a xeroderma pigmentosum human cell line by transfection with a cDNA clone library.
84:24, p. 8801 - 8804 1987 - Somatic Cell and Molecular Genetics
Canaani Dan, Immortalization of xeroderma pigmentosum cells by simian virus 40 DNA having a defective origin of DNA replication
12:1, p. 13 - 20 1986
Presentations
- "Chemotherapy Drugs and Ototoxicity"- PIHL Group Meeting 2023
- Dual Effect: Kinase inhibitors AZD5438 and Dabrafenib Alleviate Cisplatin-Induced Acute Kidney Injury and Hearing Loss. Brainstorm Presentation at Creighton University, School of Medicine. 2022
- Bellucci 2022 Symposium on Aging and Age-related Hearing Loss-Dabrafenib, a BRAF Inhibitor Protects Against Cisplatin-Induced Kidney Injury and Hearing Loss. 2022
- Bellucci Symposia 2022- Repurposing Oseltamivir to Prevent Noise-induced hearing Loss. Regina Kelmann and Emma Sailor First co-authors. 2022
- Bellucci Symposium 2022- Repurposing FDA-approved MEK Inhibitor Trametanib for Protection from Cisplatin Induced Hearing Loss. 2022
- Bellucci Symposia 2022- Aging and Age-related Hearing Loss. ERK 1/2 Inhibitor Protects from Noise-induced Hearing Loss. 2022
- Tamiflu as a Therapeutic Candidate for Noise-Induced Hearing Loss- ARO Meeting 2022. 2022
- Development of New Pharmacologic Agents for Hearing Loss and Vestibular Pathology. Center for Comparative Evolutionary Biology of Hearing, Translational Research Day, University of Maryland, College Park, School of Medicine, Baltimore, MD, Dec 9, 2021. 2021
- Gave a presentation in the 5th Chinese Hearing Research Conference on our research studies , Beijing, China 2019, titled "Drug Development for Cisplatin- and Noise- induced Hearing Loss." 2019
- Research Rounds and Seminars at Department of Pharmacology and Neuroscience 2019
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