Peter Stephen Steyger, PhD
Professor
Biomedical Sciences
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Contact
School of Medicine
Biomedical Sciences
Graduate School
Biomedical Sciences (Master of Science)
Biomedical Sciences (Doctorate)
Translational Hearing
CRISS I - Criss 1 - 431
Peter Stephen Steyger, PhD
Professor
Biomedical Sciences
Research Focus
OtotoxicityCochleotoxicity
Vestibulotoxicity
Aminoglycoside-induced toxicity
Cisplatin-induced toxicity
Mechanisms of neuro- and cytotoxicity
Physiology of Blood-Labyrinth Barrier
Trafficking of drugs and nutrients across blood barriers
Hearing Loss
Inflammation
Department
Biomedical Sciences
Position
Professor
Books
- Borse Vikrant, Ototoxic Hearing Loss and Balance Disorders: Challenges and Treatment 2022
- Inflammatory Mechanisms in Mediating Hearing Loss
Steyger Peter S., Inflammation potentiates cochlear uptake of ototoxins and drug-induced hearing loss [Book Chapter] 2018
Articles
- Steyger Peter S., Reader response 2020
- Steyger Peter, From Screen to Trial 2018
- Steyger Peter, Translating in vitro data into auditory protection 2014
Publications
- American journal of audiology
Janky Kristen, Mechanisms and Impact of Aminoglycoside-Induced Vestibular Deficits, p. 1 - 15 2023 - Pharmaceuticals
Dash Shreshtha, Local Delivery of Therapeutics to the Cochlea Using Nanoparticles and Other Biomaterials
15:9 2022 - Clinical Pharmacology and Therapeutics
McDermott John Henry, Clinical Pharmacogenetics Implementation Consortium Guideline for the Use of Aminoglycosides Based on MT-RNR1 Genotype
111:2, p. 366 - 372 2022 - Journal of Neuroinflammation
Mathy Nicholas W., A novel long intergenic non-coding RNA, Nostrill, regulates iNOS gene transcription and neurotoxicity in microglia
18:1 2021 - Otolaryngologic Clinics of North America
Steyger Peter S., Mechanisms of Ototoxicity and Otoprotection
54:6, p. 1101 - 1115 2021 - Journal of cystic fibrosis
Garinis A., 105: Ototoxicity management for patients with cystic fibrosis
20, p. S53 2021 - Frontiers in Education
Huyck Julia Jones, Supporting Equity and Inclusion of Deaf and Hard-of-Hearing Individuals in Professional Organizations
6 2021 - American Journal of Audiology
Steyger Peter S., Mechanisms of aminoglycoside-and cisplatin-induced ototoxicity
30:3S, p. 887 - 900 2021 - American Journal of Audiology
Garinis Angela C., Clinical considerations for routine auditory and vestibular monitoring in patients with cystic fibrosis
30:3S, p. 800 - 809 2021 - Hearing Research
Tian Cong, CACHD1-deficient mice exhibit hearing and balance deficits associated with a disruption of calcium homeostasis in the inner ear
409 2021 - Frontiers in Neurology
Coffin Allison B., Detecting Novel Ototoxins and Potentiation of Ototoxicity by Disease Settings
12 2021 - Frontiers in Neuroscience
Prayuenyong Pattarawadee, Preferential Cochleotoxicity of Cisplatin
15 2021 - Cold Spring Harbor Perspectives in Medicine
Kros Corné J., Aminoglycoside- and cisplatin-induced ototoxicity
9:11 2019 - Science Advances
Jiang Meiyan, Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss
5:7 2019 - Hearing Journal
Steyger Peter S., Genetic Contributions to Age-Related Hearing Loss
72:5, p. 10 - 13 2019 - Science Translational Medicine
Nyberg Sophie, Delivery of therapeutics to the inner ear
11:482 2019 - PloS one
Kachelmeier Allan, Simplified, automated methods for assessing pixel intensities of fluorescently-tagged drugs in cells
13:11 2018 - International Journal of Audiology
Garinis Angela C., Monitoring neonates for ototoxicity
57:sup4, p. S41 - S48 2018 - Steyger Peter S., Editorial 2018
- Frontiers in Cellular Neuroscience
Jiang Meiyan, Potential mechanisms underlying inflammation-enhanced aminoglycoside-induced cochleotoxicity
11 2017 - Frontiers in Cellular Neuroscience
Jiang Meiyan, Aminoglycoside-induced cochleotoxicity
11 2017 - International Journal of Pediatric Otorhinolaryngology
Garinis Angela C., Effect of gentamicin and levels of ambient sound on hearing screening outcomes in the neonatal intensive care unit
97, p. 42 - 50 2017 - Journal of Cystic Fibrosis
Garinis Angela C., The cumulative effects of intravenous antibiotic treatments on hearing in patients with cystic fibrosis
16:3, p. 401 - 409 2017 - Adler Henry J., Community network for deaf scientists 2017
- Hearing Journal
Steyger Peter S., Is Auditory Synaptopathy a Result of Drug-Induced Hearing Loss?
70:4, p. 8 - 9 2017 - Toxicology Letters
Karasawa Takatoshi, An integrated view of cisplatin-induced nephrotoxicity and ototoxicity
237:3, p. 219 - 227 2015 - Expert Opinion on Therapeutic Patents
Jiang Meiyan, An evaluation of US patent 2015065565 (A1) for a new class of SGLT2 inhibitors for treatment 1 of type II diabetes mellitus
25:11, p. 1349 - 1352 2015 - Science Translational Medicine
Koo Ja Won, Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity
7:298 2015 - Hearing Journal
Steyger Peter S., Novel Aminoglycoside Antibiotics Show Reduced Ototoxicity Risk
68:4, p. 32 - 35 2015 - Hearing Journal
Steyger Peter S., Hearing Loss Risk Factors for Cystic Fibrosis Patients
69:4, p. 8 - 9 2015 - PloS one
Yang Yuqin, Diverse Kir expression contributes to distinct bimodal distribution of resting potentials and vasotone responses of arterioles
10:5 2015 - Frontiers in Cellular Neuroscience
Li Hongzhe, Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells
9:APR 2015 - PloS one
Liu Jianping, Uptake of fluorescent gentamicin by peripheral vestibular cells after systemic administration
10:3 2015 - International Journal of Pediatric Otorhinolaryngology
Cross Campbell P., Effect of sepsis and systemic inflammatory response syndrome on neonatal hearing screening outcomes following gentamicin exposure
79:11, p. 1915 - 1919 2015 - PloS one
Jiang Meiyan, Sodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides
9:9 2014 - Otolaryngology-head and neck surgery
Luk Lauren J., Perilymphatic Gentamicin Trafficking through Basolateral Channels May Underlie Enhanced Ototoxicity by Noise-Induced Threshold Shifts
151:1_suppl, p. P222 - P222 2014 - Otolaryngology-head and neck surgery
Liao Selena, Noise Exposure in the Neonatal Intensive Care Unit: A Prospective Study
149:2_suppl, p. P249 - P249 2013 - Otolaryngology-head and neck surgery
Liao Selena, Differences in DPOAE and AABR in Noise-Exposed Infants in the Neonatal Intensive Care Unit
149:2_suppl, p. P244 - P244 2013 - Otolaryngology - Head and Neck Surgery
Quintanilla-Dieck Lourdes, Effect of systemic lipopolysaccharide-induced inflammation on cytokine levels in the murine cochlea
149:2, p. 301 - 303 2013 - PloS one
Karasawa Takatoshi, Identification of Cisplatin-Binding Proteins Using Agarose Conjugates of Platinum Compounds
8:6 2013 - Hearing Journal
Steyger Peter S., Ototoxic antibiotics
66:4, p. 24 - 26 2013 - Hearing Research
Zhang Ru, Temporal and spatial distribution of gentamicin in the peripheral vestibular system after transtympanic administration in guinea pigs
298, p. 49 - 59 2013 - Cell Biochemistry and Biophysics
Wang Tian, Bumetanide Hyperpolarizes Madin-Darby Canine Kidney Cells and Enhances Cellular Gentamicin Uptake by Elevating Cytosolic Ca2+ Thus Facilitating Intermediate Conductance Ca2+-Activated Potassium Channels
65:3, p. 381 - 398 2013 - PloS one
Uribe Phillip M., Aminoglycoside-Induced Hair Cell Death of Inner Ear Organs Causes Functional Deficits in Adult Zebrafish (Danio rerio)
8:3 2013 - PloS one
Uribe Phillip M., Dimethyl Sulfoxide (DMSO) Exacerbates Cisplatin-induced Sensory Hair Cell Death in Zebrafish (Danio rerio)
8:2 2013 - Otolaryngology-head and neck surgery
Quintanilla-Dieck Lourdes, Cytokines Induced by Gentamicin and Sepsis in the Cochlea
147:2_suppl, p. P84 - P84 2012 - Journal of Clinical Oncology
Brock Penelope R., Platinum-induced ototoxicity in children
30:19, p. 2408 - 2417 2012 - Hearing Journal
Steyger Peter S., Journal club
65:4, p. 18 - 20 2012 - Hearing Research
Zhang Yi Bo, Uptake of gentamicin by vestibular efferent neurons and superior olivary complex after transtympanic administration in guinea pigs
283:1-2, p. 169 - 179 2012 - Natural Product Communications
Escobedo Jorge O., Live cell imaging of a fluorescent gentamicin conjugate
7:3, p. 317 - 320 2012 - JARO - Journal of the Association for Research in Otolaryngology
Stepanyan Ruben S., TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells
12:6, p. 729 - 740 2011 - Toxicological Sciences
Karasawa Takatoshi, Calreticulin binds to gentamicin and reduces drug-induced ototoxicity
124:2, p. 378 - 387 2011 - Integrative Biology
Karasawa Takatoshi, Intracellular mechanisms of aminoglycoside-induced cytotoxicity
3:9, p. 879 - 886 2011 - Audiology and Neuro-Otology
Koo Ja Won, Infection-mediated vasoactive peptides modulate cochlear uptake of fluorescent gentamicin
16:6, p. 347 - 358 2011 - Seminars in hearing
Steyger Peter S., Mechanisms Involved in Ototoxicity
32:3, p. 217 - 228 2011 - Scientific Reports
Li Hongzhe, Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells
1 2011 - PloS one
Alharazneh Abdelrahman, Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity
6:7 2011 - PloS one
Li Hongzhe, Acoustic trauma increases cochlear and hair cell uptake of gentamicin
6:4 2011 - Cell Death and Disease
Karasawa T., CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity
1:11 2010 - Laryngoscope
Zhang Yiliang, Comparison of gentamicin distribution in the inner ear following administration via the endolymphatic sac or round window
120:10, p. 2054 - 2060 2010 - Hearing Research
Wang Qi, Competitive antagonism of fluorescent gentamicin uptake in the cochlea
268:1-2, p. 250 - 259 2010 - Otology and Neurotology
Zhai Feng, Evidence-Based modification of intratympanic gentamicin injections in patients with intractable vertigo
31:4, p. 642 - 648 2010 - The FASEB journal
Wang Tian, Ionic mechanisms for bumetanide enhancement on aminoglycoside ototoxicity: a study with MDCK cells
24:S1, p. lb486 - lb486 2010 - Brain Research
Tiede LeAnn, Metabolic imaging of the organ of corti — A window on cochlea bioenergetics
1277, p. 37 - 41 2009 - JARO - Journal of the Association for Research in Otolaryngology
Wang Qi, Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells
10:2, p. 205 - 219 2009 - The FASEB journal
Ma Ke‐tao, Possible gentamicin trafficking channels in guinea pig cochlear stria vascularis cells
23:S1 2009 - Seminars in Hearing
Steyger Peter S., Potentiation of chemical ototoxicity by noise
30:1, p. 38 - 46 2009 - Noise and Health
Li Hongzhe, Synergistic ototoxicity due to noise exposure and aminoglycoside antibiotics
11:42, p. 26 - 32 2009 - Perspectives on hearing and hearing disorders. Research and diagnostics
Steyger Peter S., Synergistic Ototoxicity of Noise and Chemical Ototoxins
12:2, p. 48 2008 - Journal of Cell Science
Karasawa Takatoshi, TRPV4 enhances the cellular uptake of aminoglycoside antibiotics
121:17, p. 2871 - 2879 2008 - Hearing Research
Dai Chun Fu, A systemic gentamicin pathway across the stria vascularis
235:1-2, p. 114 - 124 2008 - Hearing Research
Hordichok Andrew J., Closure of supporting cell scar formations requires dynamic actin mechanisms
232:1-2, p. 1 - 19 2007 - Hearing Research
Dai C. F., Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo
213:1-2, p. 64 - 78 2006 - Hearing Research
Myrdal Sigrid E., TRPV1 regulators mediate gentamicin penetration of cultured kidney cells
204:1-2, p. 170 - 182 2005 - Hearing Research
Dai C. F., Expression of Trk A receptors in the mammalian inner ear
187:1-2, p. 1 - 11 2004 - Neuroscience
Vass Z., Co-localization of the vanilloid capsaicin receptor and substance P in sensory nerve fibers innervating cochlear and vertebro-basilar arteries
124:4, p. 919 - 927 2004 - JARO - Journal of the Association for Research in Otolaryngology
Steyger P. S., Uptake of Gentamicin by Bullfrog Saccular Hair Cells in vitro
4:4, p. 565 - 578 2003 - Journal of Neurophysiology
Zheng Jiefu, Vanilloid receptors in hearing
90:1, p. 444 - 455 2003 - Journal of Neurocytology
Jensen-Smith Heather C., Cell type-specific reduction of β tubulin isotypes synthesized in the developing gerbil organ of Corti
32:2, p. 185 - 197 2003 - Journal of Neurocytology
Jensen-Smith H. C., Cell type-specific reduction of β tubulin isotypes synthesized in the developing gerbil organ of Corti
32:2, p. 185 - 197 2003 - Hearing Research
Qiu Jian Hua, Co-existence of tyrosine hydroxylase and calcitonin gene-related peptide in cochlear spiral modiolar artery of guinea pigs
155:1-2, p. 152 - 160 2001 - Journal of Biological Chemistry
Silberbach Michael, Extracellular signal-regulated protein kinase activation is required for the anti-hypertrophic effect of atrial natriuretic factor in neonatal rat ventricular myocytes
274:35, p. 24858 - 24864 1999 - ImmunoMethods
Steyger Peter, Assessing confocal microscopy systems for purchase
18:4, p. 435 - 446 1999 - Journal of Neuroscience
Steyger Peter S., Myosin Iβ is located at tip link anchors in vestibular hair bundles
18:12, p. 4603 - 4615 1998 - Adler H. J., Early education of the deaf [10] 1998
- Hearing Research
Baird R. A., Intracellular distributions and putative functions of calcium-binding proteins in the bullfrog vestibular otolith organs
103:1-2, p. 85 - 100 1997 - Journal of Controlled Release
Steyger P. S., Intratumoural
39:1, p. 35 - 46 1996 - Hearing Research
Steyger P. S., Visualization of newt aragonitic otoconial matrices using transmission electron microscopy
92:1-2, p. 184 - 191 1995 - Hearing Research
Hallworth Richard J., Atomic force microscope observations of otoconia in the newt
85:1-2, p. 115 - 121 1995 - Hearing Research
Steyger Peter S., The morphogenic features of otoconia during larval development of Cynops pyrrhogaster, the Japanese red-bellied newt
84:1-2, p. 61 - 71 1995 - British Journal of Cancer
Seymour L. W., Tumour tropism and anti-cancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16F10 melanoma
70:4, p. 636 - 641 1994 - Journal of Electron Microscopy Technique
Furness David N., Organization of microtubules in cochlear hair cells
15:3, p. 261 - 279 1990 - Hearing Research
Steyger P. S., Tubulin and microtubules in cochlear hair cells
42:1, p. 1 - 16 1989 - British Journal of Audiology
Steyger P. S., Immunocytochemistry of cytoskeletal proteins in the guinea pig cochleaa comparison of staining patterns with different commercially available antibodies and ultrastructure
23:2, p. 143 - 174 1989
Presentations
- Hospital medication-induced hearing loss presented during ENT Fall Education Series at the Department of Otolaryngology-Head and Neck Surgery at University Hospitals Cleveland Medical Center 2022
- Mechanisms of Drug-induced Hearing Loss during Research Brainstorming virtual meeting 2022
- Poster Presentation: F Taghizadeh, M Jiang, W Meier, P Steyger. TLR4 and MyD88 Activation of TRPV1 Modulates Cellular Uptake of Aminoglycosides. 45th Annual Mid-Winter Meeting of the Association for Research in Otolaryngology, San Jose, CA, 1/2020 2020
- Podium Presentation: F Taghizadeh, M Jiang, W Meier, P Steyger TLR4 and MyD88 activation of TRPV1 modulates cellular uptake of aminoglycosides. 2nd International Society for Inner Ear Therapeutics, Hannover, Germany, 11/2019 2019
- Keynote speaker: Otopathology of ototoxicity and noise exposure: From animal models to audiological management, NCRAR biennial conference, Portland VA, OR, Sept 2019 2019
Awards
- University Research Award
Creighton University - Keynote Speaker
Keynote speaker: Otopathology of ototoxicity and noise exposure: From animal models to audiological management, NCRAR biennial conference, Portland VA, OR, Sept 2019.
NCRAR biennial conference - Guest Editor
Research topic: Cellular Mechanisms of Ototoxicity.
Frontiers in Celluar Neuroscience - Guest Editor
Research topic: Drug delivery to the inner ear.
Frontiers in Celluar Neuroscience - Lead Discussant
Ototoxicity Sub-committee for Pharmaceutical Interventions for Hearing Loss (PIHL), Hearing Center of Excellence, US Department of Defense
Hearing Center of Excellence (DOD) - Associate Editor
Frontiers in Medicine - Translational Medicine