Garrett A . Soukup, PhD
Professor
Biomedical Sciences
![G Soukup](/sites/default/files/styles/card_contact/public/2021-12/G%20Sokup.jpg?itok=GOsgTQBv)
Contact
School of Medicine
Biomedical Sciences
Graduate School
Biomedical Sciences (Master of Science)
Biomedical Sciences (Doctorate)
Translational Hearing
CRISS I - Criss 1 - 325
Garrett A . Soukup, PhD
Professor
Biomedical Sciences
Research Focus
Garrett Soukup's research interests over his career have included RNA-ligand interactions, mechanisms of RNA catalysis, biological roles of functional RNAs including ribozymes and riboswitches, and regulatory roles of microRNAs in the development and maintenance of mechanosensory cells and sensory neurons important for hearing.Department
Biomedical Sciences
Position
Professor
Books
- Catalytic RNA
Soukup Garrett A, Chapter Five: The Structural and Functional Uniqueness of the glmS Ribozyme [Book Chapter] 2013 - Catalytic RNA
Soukup Garrett A, Chapter Two: Bridging the Gap Between Theory and Experiment to Derive a Detailed Understanding of Hammerhead Ribozyme Cata [Book Chapter] 2013 - Catalytic RNA
Soukup Garrett A, Chapter One: The Hammerhead Ribozyme: Structure, Catalysis, and Gene Regulation [Book Chapter] 2013 - Catalytic RNA
Soukup Garrett A, Chapter Six: The Role of snRNAs in Spliceosomal Catalysis [Book Chapter] 2013 - Soukup Garrett A, Catalytic RNA 2013
- Catalytic RNA
Soukup Garrett A, Chapter Four: HDV Family of Self-Cleaving Ribozymes [Book Chapter] 2013 - Catalytic RNA
Soukup Garrett A, Chapter Three: A Mechanistic Comparison of the Varkud Satellite and Hairpin Ribozymes [Book Chapter] 2013 - Catalytic RNA
Soukup Garrett A, Contributors [Book Chapter] 2013 - Catalytic RNA
Soukup Garrett A, Color Plate [Book Chapter] 2013 - Catalytic RNA
Soukup Garrett A., Preface [Book Chapter] 2013 - Non-Protein Coding RNAs
Soukup Garrett A., Structure and mechanism of the glmS ribozyme [Book Chapter] 2009 - Nucleic acid switches and sensors
Soukup Garrett A., Allosteric ribozymes as molecular switches and sensors [Book Chapter] 2006
Articles
- McCarthy T. J., Ligand Requirements for glmS Ribozyme Self-Cleavage (Erratum) 2006
- McCarthy Tom J., Ligand Requirements for glmS Ribozyme Self-Cleavage (DOI:10.1016/j.chembiol.2005.09.006) 2006
Publications
- Molecular Neurobiology
Banks Samantha A., Sensational MicroRNAs
57:1, p. 358 - 371 2020 - Scientific Reports
Weston Michael D., A mouse model of MIR-96, MIR-182 and MIR-183 misexpression implicates MIRNAs in cochlear cell fate and homeostasis
8:1 2018 - Biophysical journal
Strauss-Soukup Juliane, Ornithine Decarboxylase Antizyme Pseudoknot RNA Binding to Spermine Regulates Gene Expression
114:3, p. 438a - 438a 2018 - Plos One
Ebeid Michael, Transcriptome-Wide Comparison of the Impact of Atoh1 and miR-183 Family on Pluripotent Stem Cells and Multipotent Otic Progenitor Cells
12:7, p. E0180855 - E0180855 2017 - Molecular therapy
Kim Ju-hyun, 139. Controllable Target-Specific Transgene Induction Using an Allosteric trans-Splicing Ribozyme
23, p. S56 - S57 2015 - PLoS One
Zhang Qian, Identifying microRNAs involved in aging of the lateral wall of the cochlear duct
9:11, p. e112857 - e112857 2014 - Journal of Neuroscience
Liu H., Characterization of transcriptomes of cochlear inner and outer hair cells
34:33, p. 11085 - 11095 2014 - Journal of Neuroscience
Liu Heping, Characterization of Transcriptomes of Cochlear Inner and Outer Hair Cells
34:33, p. 11085 - 11095 2014 - ACS Chemical Biology
Kim Juhyun, Conditional and target-specific transgene induction through RNA replacement using an allosteric trans-splicing ribozyme
9:11, p. 2491 - 2495 2014 - Soukup Garrett A., Preface. Catalytic RNA. 2013
- PloS one
Zhang Qian, Identifying MicroRNAs Involved in Degeneration of the Organ of Corti during Age-Related Hearing Loss
8:4 2013 - Nebraska Academy of Sciences, PO Box 880410 Lincoln NE 68588-0410 United States. [np]. Apr 2012
Holmes Zachariah, EFFECT OF MICRORNA-183 FAMILY ON EXPRESSION OF GENES THAT REINFORCE NEUROSENSORY CELL FATE IN THE INNER EAR 2012 - Indian Journal of Human Genetics
Barritt Laura C., Conditional deletion of the human ortholog gene Dicer1 in Pax2-Cre expression domain impairs orofacial development
18:3, p. 310 - 319 2012 - Developmental Dynamics
Weston Michael D., MicroRNA-183 family expression in hair cell development and requirement of microRNAs for hair cell maintenance and survival
240:4, p. 808 - 819 2011 - International Journal for Parasitology
Gong Ai-Yu, MicroRNA-122 controls expression of intercellular adhesion molecule-1 in epithelial cells in response to Cryptosporidium parvum infection
41:3/4, p. 397 - 403 2011 - Chembiochem
Klawuhn K., Analysis of Metal Ion Dependence in glmS Ribozyme Self-Cleavage and Coenzyme Binding
11:18, p. 2567 - 2571 2010 - Genome Medicine
Weston Michael D., MicroRNAs sound off
1:6, p. 59 2009 - Brain Research
Soukup Garrett A., Little but loud: Small RNAs have a resounding affect on ear development
1277, p. 104 - 114 2009 - Developmental Biology
Soukup Garrett A., Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice
328:2, p. 328 - 341 2009 - Methods in Molecular Biology
Soukup Garrett A., Identification of metabolite-riboswitch interactions using nucleotide analog interference mapping and suppression
540, p. 193 - 206 2009 - Cell and Tissue Research
Beisel Kirk W., Regenerating cochlear hair cells: quo vadis stem cell
333:3, p. 373 - 379 2008 - Panminerva Medica
Pauley S., Stem cells and molecular strategies to restore hearing
50:1, p. 41 - 53 2008 - Evolution & Development
Pierce Marsha L., MicroRNA-183 family conservation and ciliated neurosensory organ expression
10:1, p. 106 - 113 2008 - International Journal of Developmental Biology
Fritzsch Bernd, Molecular evolution of the vertebrate mechanosensory cell and ear
51:6-7, p. 663 - 678 2007 - Brain Research
Weston Michael D., MicroRNA gene expression in the mouse inner ear
1111:1, p. 95 - 104 2006 - Nature Structural and Molecular Biology
Jansen Joshua A., Backbone and nucleobase contacts to glucosamine-6-phosphate in the glmS ribozyme
13:6, p. 517 - 523 2006 - Nucleic Acids Research
Soukup Garrett A., Core requirements for glmS ribozyme self-cleavage reveal a putative pseudoknot structure
34:3, p. 968 - 975 2006 - Chemistry and Biology
McCarthy Tom J., Ligand requirements for glmS ribozyme self-cleavage
12:11, p. 1221 - 1226 2005 - Chemistry and Biology
Soukup Garrett A., Aptamers meet allostery
11:8, p. 1031 - 1032 2004 - Current Opinion in Structural Biology
Soukup Juliane K., Riboswitches exert genetic control through metabolite-induced conformational change
14:3, p. 344 - 349 2004 - American Journal of PharmacoGenomics
Steele David, Engineered catalytic RNA and DNA
3:2, p. 131 - 144 2003 - American Journal of PharmacoGenomics
Steele David, Engineered catalytic RNA and DNA : new biochemical tools for drug discovery and design
3:2, p. 131 - 144 2003 - Nucleic Acids Research
Kertsburg Alexis, A versatile communication module for controlling RNA folding and catalysis
30:21, p. 4599 - 4606 2002 - Nucleic Acids Research
Kertsburg Alexis, A versatile communication module for controlling RNA folding and catalysis
30:21, p. 4599 - 4606 2002 - Nucleic Acids Research
Jose Antony M., Cooperative binding of effectors by an allosteric ribozyme
29:7, p. 1631 - 1637 2001 - RNA
Soukup Garrett A., Generating new ligand-binding RNAs by affinity maturation and disintegration of allosteric ribozymes
7:4, p. 524 - 536 2001 - Current Opinion in Structural Biology
Soukup Garrett A., Allosteric nucleic acid catalysts
10:3, p. 318 - 325 2000 - Journal of Molecular Biology
Soukup Garrett A., Altering molecular recognition of RNA aptamers by allosteric selection
298:4, p. 623 - 632 2000 - Trends in Biotechnology
Soukup Garrett A., Nucleic acid molecular switches
17:12, p. 469 - 476 1999 - RNA
Soukup Garrett A., Relationship between internucleotide linkage geometry and the stability of RNA
5:10, p. 1308 - 1325 1999 - Structure
Soukup Garrett A., Design of allosteric hammerhead ribozymes activated by ligand-induced structure stabilization
7:7, p. 783 - 791 1999 - Proceedings of the National Academy of Sciences of the United States of America
Soukup Garrett A., Engineering precision RNA molecular switches
96:7, p. 3584 - 3589 1999 - Nature Structural Biology
Koizumi Makoto, Allosteric selection of ribozymes that respond to the second messengers cGMP and cAMP
6:11, p. 1062 - 1071 1999 - Nucleic acids symposium series
Koizumi M., Allosteric ribozymes sensitive to the second messengers cAMP and cGMP., p. 275 - 276 1999 - Nucleic Acids Research
Soukup Garrett A., Selection and characterization of RNAs that relieve transcriptional interference in Escherichia coli
26:11, p. 2715 - 2722 1998 - Journal of Molecular Biology
Soukup Garrett A., Selection of RNAs that bind to duplex DNA at neutral pH
259:2, p. 216 - 228 1996 - Bioconjugate Chemistry
Soukup Garrett A., Preparation of Oligonucleotide-Biotin Conjugates with Cleavable Linkers
6:1, p. 135 - 138 1995
Awards
- 2021 Dedicated Teacher Award
Creighton University School of Medicine