Claudia Gragnoli, MD, PhD

Professor

Contact

School of Medicine
Department of Medicine
Endocrinology
Fellowship - endocrinology

Claudia Gragnoli, MD, PhD

Professor

Department

Medicine

Position

Professor

Articles

  • Gragnoli Claudia, Erratum 2005

Publications

  • Aspects of molecular medicine
    Amin Mutaz, Genome-wide linkage and association of novel genes and pathways with type 2 diabetes in Italian families
    4 2024
  • Aspects of molecular medicine
    Wu Rongling, Linkage and association of rs3110045 and rs28499085 variants in the thyrotropin-releasing hormone receptor (TRHR) gene with the risk of familial type 2 diabetes
    3 2024
  • Journal of ovarian research
    Postolache Teodor T, The melatonin receptor genes are linked and associated with the risk of polycystic ovary syndrome
    17:1, p. 17 - 17 2024
  • Journal of ovarian research
    Syed Shumail, The glucocorticoid receptor gene (NR3C1) is linked to and associated with polycystic ovarian syndrome in Italian families
    17:1, p. 13 - 13 2024
  • European archives of psychiatry and clinical neuroscience
    Del Bosque-Plata Laura, LD block disorder-specific pleiotropic roles of novel CRHR1 in type 2 diabetes and depression disorder comorbidity 2023
  • Journal of ovarian research
    Amin Mutaz, The prolactin receptor gene (PRLR) is linked and associated with the risk of polycystic ovarian syndrome
    16:1, p. 222 - 222 2023
  • Proceedings of the National Academy of Sciences - PNAS
    Wu Shuang, The metabolomic physics of complex diseases
    120:42, p. e2308496120 - e2308496120 2023
  • European review for medical and pharmacological sciences
    Amin M, Author Correction: Linkage and association of novel DRD2 variants to the comorbidity of type 2 diabetes and depression
    27:18, p. 8322 - 8322 2023
  • Drug discovery today
    Wang Yu, A pleiotropic–epistatic entangelement model of drug response, p. 103790 2023
  • Journal of ovarian research
    Amin Mutaz, Linkage and association of variants in the dopamine receptor 2 gene (DRD2) with polycystic ovary syndrome
    16:1, p. 158 - 158 2023
  • Genes & diseases
    Amin Mutaz, The role of melatonin receptor 1B gene (MTNR1B) in the susceptibility to depression and type 2 diabetes comorbidity 2023
  • Drug discovery today
    Feng Li, A personalized pharmaco-epistatic network model of precision medicine
    28:7, p. 103608 - 103608 2023
  • European review for medical and pharmacological sciences
    Amin M, Melatonin receptor 1A (MTNR1A) gene linkage and association to type 2 diabetes in Italian families
    27:10, p. 4688 2023
  • International journal of molecular sciences
    Amin Mutaz, Novel Risk Variants in the Oxytocin Receptor Gene (OXTR) Possibly Linked to and Associated with Familial Type 2 Diabetes
    24:7, p. 6282 2023
  • European review for medical and pharmacological sciences
    Amin M., Oxytocin receptor (OXTR) is a risk gene for polycystic ovarian syndrome
    27:6, p. 2634 - 2638 2023
  • Aspects of Molecular Medicine
    Amin Mutaz, Novel linkage and association of the mineralocorticoid receptor gene (NR3C2) with familial type 2 diabetes and depression and their comorbidity
    1 2023
  • European review for medical and pharmacological sciences
    Amin M., The mineralocorticoid receptor gene (NR3C2) is linked to and associated with polycystic ovarian in Italian families
    27:3, p. 942 - 948 2023
  • Journal of the Endocrine Society
    Amin Mutaz, ODP258 CRHR1 gene shows extensive linkage to major depression and type 2 diabetes in Italian families
    6:Supplement_1, p. A339 - A340 2022
  • International journal of molecular sciences
    Amin Mutaz, Familial Linkage and Association of the NR3C1 Gene with Type 2 Diabetes and Depression Comorbidity
    23:19, p. 11951 2022
  • International journal of molecular sciences
    Amin Mutaz, Comorbidity of Novel CRHR2 Gene Variants in Type 2 Diabetes and Depression
    23:17 2022
  • International journal of molecular sciences
    Amin Mutaz, Implication of Melanocortin Receptor Genes in the Familial Comorbidity of Type 2 Diabetes and Depression
    23:15 2022
  • Journal of Cellular Physiology
    del Bosque-Plata Laura, The broad pathogenetic role of TCF7L2 in human diseases beyond type 2 diabetes
    237:1, p. 301 - 312 2022
  • Diabetes
    Del Bosque-Plata Laura, The Role of TCF7L2 in Type 2 Diabetes
    70:6, p. 1220 - 1228 2021
  • Gut Microbes
    Jiang Libo, A behavioral model for mapping the genetic architecture of gut-microbiota networks
    13:1 2021
  • Cancers
    Sun Lidan, Computational identification of gene networks as a biomarker of neuroblastoma risk
    12:8, p. 1 - 17 2020
  • Journal of Psychiatric Research
    Akram Faisal, Seasonal affective disorder and seasonal changes in weight and sleep duration are inversely associated with plasma adiponectin levels
    122, p. 97 - 104 2020
  • Computational and Structural Biotechnology Journal
    Sang Mengmeng, A rewiring model of intratumoral interaction networks
    18, p. 45 - 51 2020
  • iScience
    Jiang Libo, A Drive to Driven Model of Mapping Intraspecific Interaction Networks
    22, p. 109 - 122 2019
  • Biological psychiatry (1969)
    Wadhawan Abhishek, S144. Obesity is Associated With Anhedonia Only in the Younger Amish Women
    85:10, p. S352 - S352 2019
  • American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
    Postolache Teodor T., Co-shared genetics and possible risk gene pathway partially explain the comorbidity of schizophrenia, major depressive disorder, type 2 diabetes, and metabolic syndrome
    180:3, p. 186 - 203 2019
  • Drug Discovery Today
    Wang Qian, A unified mapping framework of multifaceted pharmacodynamic responses to hypertension interventions
    24:3, p. 883 - 889 2019
  • Drug Discovery Today
    Wei Kun, Mapping genes for drug chronotherapy
    23:11, p. 1883 - 1888 2018
  • Gragnoli Claudia, Breastfeeding and future maternal health- no causal evidence 2018
  • Pteridines
    Mohyuddin Hira, Seasonality of blood neopterin levels in the Old Order Amish
    28:3-4, p. 163 - 176 2017
  • Pteridines
    Ahmad Zaki, Sleep onset insomnia, daytime sleepiness and sleep duration in relationship to Toxoplasma gondii IgG seropositivity and serointensity
    28:3-4, p. 195 - 204 2017
  • Frontiers in Public Health
    Mathai Ashwin Jacob, Blood Levels of Monoamine Precursors and Smoking in Patients with Schizophrenia
    4 2016
  • Trends in Genetics
    Zhu Xuli, Integrating Evolutionary Game Theory into Mechanistic Genotype-Phenotype Mapping
    32:5, p. 256 - 268 2016
  • Translational Psychiatry
    Gragnoli C., Dopamine–prolactin pathway potentially contributes to the schizophrenia and type 2 diabetes comorbidity
    6:4 2016
  • Scientific Reports
    Hao Han, T2D and Depression Risk Gene Proteasome Modulator 9 is Linked to Insomnia
    5 2015
  • Journal of Cellular Physiology
    Gragnoli Claudia, Proteasome modulator 9 gene SNPs, responsible for anti-depressant response, are in linkage with generalized anxiety disorder
    229:9, p. 1157 - 1159 2014
  • Application of Clinical Genetics
    Gragnoli Claudia, Hypothesis of the neuroendocrine cortisol pathway gene role in the comorbidity of depression, type 2 diabetes, and metabolic syndrome
    7, p. 43 - 53 2014
  • Cardiovascular Diabetology
    Gragnoli Claudia, Overweight condition and waist circumference and a candidate gene within the 12q24 locus
    12:1 2013
  • Current Medicinal Chemistry
    Gragnoli C., Proteasome modulator 9 and depression in type 2 diabetes
    19:30, p. 5178 - 5180 2012
  • Journal of Cellular Physiology
    Oberweis Brandon, Potential role of prolactin in antipsychotic-mediated association of schizophrenia and type 2 diabetes
    227:8, p. 3001 - 3006 2012
  • Journal of Cellular Physiology
    Gragnoli Claudia, Proteasome modulator 9 is linked to microvascular pathology of T2D
    227:8, p. 3116 - 3118 2012
  • Journal of Cellular Physiology
    Gragnoli Claudia, Depression and type 2 diabetes
    227:6, p. 2318 - 2322 2012
  • Ophthalmic Genetics
    Gragnoli Claudia, Proteasome modulator 9 gene is linked to diabetic and non-diabetic retinopathy in T2D
    32:4, p. 228 - 230 2011
  • Diabetes Research and Clinical Practice
    Gragnoli Claudia, Proteasome modulator 9 and carpal tunnel syndrome
    94:2, p. e47 - e49 2011
  • Journal of Diabetes and its Complications
    Gragnoli Claudia, PSMD9 is linked to type 2 diabetes neuropathy
    25:5, p. 329 - 331 2011
  • Cardiovascular Diabetology
    Gragnoli Claudia, Proteasome Modulator 9 SNPs are linked to hypertension in type 2 diabetes families
    10 2011
  • Diabetes Research and Clinical Practice
    Gragnoli Claudia, T2D-nephropathy linkage within 12q24 locus
    92:3, p. e73 - e75 2011
  • Cardiovascular Diabetology
    Gragnoli Claudia, Hypercholesterolemia and a candidate gene within the 12q24 locus
    10 2011
  • Cardiovascular Diabetology
    Gragnoli Claudia, Proteasome modulator 9 and macrovascular pathology of T2D
    10 2011
  • Journal of diabetes & metabolism
    Gragnoli Claudia, Insomnia linked to a T2D Gene
    1:S1 2011
  • Journal of Cellular Physiology
    Gragnoli Claudia, PSMD9 is linked to MODY3
    223:1, p. 1 - 5 2010
  • Journal of Cellular Physiology
    Gragnoli Claudia, PSMD9 gene in the NIDDM2 locus is linked to type 2 diabetes in Italians
    222:2, p. 265 - 267 2010
  • Diabetes Research and Clinical Practice
    Meenakshisundaram Ramachandran, CDK4 IVS4-nt40G → A SNP and type 2 diabetes in Italians
    86:2, p. e28 - e30 2009
  • Journal of Cellular Physiology
    Meenakshisundaram Ramachandran, CDK4 IVS4-nt40G→A and T2D-associated obesity in Italians rapid communication
    221:2, p. 273 - 275 2009
  • Obesity Surgery
    Spanakis Elias, Successful medical management of status post-roux-en-y-gastric-bypass hyperinsulinemic hypoglycemia
    19:9, p. 1333 - 1334 2009
  • Obesity Surgery
    Spanakis Elias, Bariatric surgery, safety and type 2 diabetes
    19:3, p. 363 - 368 2009
  • Journal of Experimental and Clinical Cancer Research
    Meenakshisundaram Ramachandran, CDK4 IVS4-nt40 AA genotype and obesity-associated tumors/cancer in Italians - A case-control study
    28:1 2009
  • Journal of Cellular Physiology
    Spanakis Elias, AVPR2 variants and mutations in nephrogenic diabetes insipidus
    217:3, p. 605 - 617 2008
  • Journal of Cellular Physiology
    Gragnoli Claudia, CHOP T/C and C/T haplotypes contribute to early-onset type 2 diabetes in Italians
    217:2, p. 291 - 295 2008
  • Journal of Cellular Physiology
    Jonnakuty Catherine, What do we know about serotonin?
    217:2, p. 301 - 306 2008
  • Journal of Cellular Physiology
    Gragnoli Claudia, The CM cell line derived from liver metastasis of malignant human insulinoma is not a valid beta cell model for in vitro studies
    216:2, p. 569 - 570 2008
  • Journal of Cellular Physiology
    Jonnakuty Catherine, Karyotype of the human insulinoma CM cell line - Beta cell model in vitro?
    213:3, p. 661 - 662 2007
  • Journal of Cellular Physiology
    Gragnoli Claudia, Linkage studies for T2D in chop and C/EBPbeta chromosomal regions in Italians
    213:2, p. 552 - 555 2007
  • Obesity and metabolism
    Gragnoli Claudia, PPAR gamma P12A variant in type 2 diabetes in Italians
    3:3, p. 99 - 100 2007
  • Journal of Cellular Physiology
    Gragnoli C., PSMD9 gene variants within NIDDM2 may rarely contribute to type 2 diabetes
    212:3, p. 568 - 571 2007
  • Obesity and metabolism
    Gragnoli Claudia, Kir6.2 (KCNJ11) E23K variant in Type 2 diabetes in Italians
    3:2, p. 97 - 98 2007
  • Minerva Medica
    Gragnoli C., Meta-analysis of the IPF1 D76N polymorphism in a worldwide type 2 diabetes population
    98:3, p. 163 - 166 2007
  • Obesity and metabolism
    Milord Edrice, Chromosome 10 locus in linkage to type 2 diabetes in Italians
    3:1, p. 44 - 47 2007
  • Minerva Medica
    Milord E., NEUROG3 variants and type 2 diabetes in Italians
    97:5, p. 373 - 378 2006
  • Metabolism: Clinical and Experimental
    Gragnoli Claudia, IPF-1/MODY4 gene missense mutation in an Italian family with type 2 and gestational diabetes
    54:8, p. 983 - 988 2005
  • Metabolism: Clinical and Experimental
    Gragnoli Claudio, Linkage study of the glucagon receptor gene with type 2 diabetes mellitus in Italians
    54:6, p. 786 - 787 2005
  • Metabolism: Clinical and Experimental
    Gragnoli Claudia, Triple genetic variation in the HNF-4α gene is associated with early-onset type 2 diabetes mellitus in a Philippino family
    53:8, p. 959 - 963 2004
  • Diabetologia
    Gragnoli C., Early-onset Type II diabetes mellitus in Italian families due to mutations in the genes encoding hepatic nuclear factor 1α and glucokinase
    44:10, p. 1326 - 1329 2001
  • Human mutation
    Godart François, Identification of seven novel nucleotide variants in the hepatocyte nuclear factor-1α (TCF1) promoter region in MODY patients
    15:2, p. 173 - 180 2000
  • Diabetes
    Gragnoli Claudia, Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4α binding site in the promoter of the hepatocyte nuclear factor-1α gene
    46:10, p. 1648 - 1651 1997
  • Journal of Clinical Investigation
    Lindner Tom, Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4α/MODY1 gene
    100:6, p. 1400 - 1405 1997
  • Diabetes
    Lindner Tom, The 31-cM region of chromosome 11 including the obesity gene tubby and ATP-sensitive potassium channel genes, SUR1 and Kir6.2, Does not contain a major susceptibility locus for NIDDM in 127 non-hispanic white affected sibships
    46:7, p. 1227 - 1229 1997
  • Diabetologia
    Pozzilli P., Double blind trial of nicotinamide in recent-onset IDDM (the IMDIAB III study)
    38:7, p. 848 - 852 1995
  • Journal of Endocrinology
    Pozzilli P., New and old trends for treating organ-specific autoimmune endocrinopathies
    145:2, p. 195 - 199 1995
  • Human Genetics
    Baroni Marco G., Affected sib-pair analysis of the GLUT1 glucose transporter gene locus in non-insulin-dependent diabetes mellitus (NIDDM)
    93:6, p. 675 - 680 1994
  • Acta Therapeutica
    Baroni M. G., Therapy with a thymic extract and reduced recurrence of low urinary tract infections in patients with diabetes mellitus
    19:3, p. 283 - 294 1993

Presentations

  • Amin M and Gragnoli C. Genome-Wide Linkage and Association Study Identifies Novel Genes and Pathways Implicated in Polycystic Ovarian Syndrome. European Society of Human Genetics Hybrid Meeting, Glasgow, Scotland, UK, June10-13, 2023, submitted 2023
  • del Bosque-Plata L, Amin M, Wu R, Postolache T, and Gragnoli C. Novel TCF7L2 Familial Linkage and Association with Type 2 Diabetes, Depression, and Their Comorbidity. European Society of Human Genetics Hybrid Meeting, Glasgow, Scotland, UK, June10-13, 2023, submitted 2023
  • Amin M, del Bosque-Plata L, Gonzalez-Ramirez R, Wu R, Postolache TT, Vergare M, Gordon, Ott J, PhD, and Gragnoli C. CRHR1 Gene Shows Extensive Linkage to Major Depression and Type 2 Diabetes in Italian families. Endocrine Society 2022, Atlanta, GA-June 11-14, 2022 2022
  • Amin M, Ott J, Wu R, Postolache T, Vergare M, Gragnoli C. Comorbidity of CRHR2 Gene Variants in Type 2 Diabetes and Depression. 30th European Congress of Psychiatry (EPA), Budapest, Hungary-April 2-5, 2022 2022
  • Amin M, Ott J, Wu R, Postolache T, Vergare M, Gragnoli C. Association of CRHR2 Gene Variants with Type 2 Diabetes and Depression. Psych Congress Europe 2022, Barcelona, Spain-February 23-25, 2022 2022
  • Leadership Speaker Series, CUSOM 2022
  • Invited speakers for Endocrine Grand Round and Medicine Grand Round to present on R adiofrequency Ablation (RFA) Technique used to cure benign thyroid nodules andm alignant thyroid nodules 2021