Janee B . Gelineau-van Waes, DVM, PhD

Department

Pharmacology and Neuroscience

Position

Associate Professor

Books

• Reproductive and Developmental Toxicology
  Waes Janee Gelineau van, Fumonisins [Book Chapter] 2022
• Developmental Toxicology
  Sant K. E., Fumonisin, Folate and other Methyl Donors and Neural Tube Defects [Book Chapter] 2018
• World Nutrition Forum 2012
  Gelineau-van Waes, Development of Biomarkers to Assess Fumonisin Exposure and Birth Defects [Book Chapter] 2012
• Reproductive and Developmental Toxicology
  Voss K. A., Fumonisins [Book Chapter] 2011
• Developmental Toxicology
  Gelineau-van Waes J., Fumonisin, Folate, and Neural Tube Defects [Book Chapter] 2010
• Advances in Food and Nutrition Research
  Gelineau-van Waes J., Chapter 5 Maternal Fumonisin Exposure as a Risk Factor for Neural Tube Defects [Book Chapter] 2009
• Sphingolipid Biology
  Riley Ronald T., Fumonisin inhibition of ceramide synthase [Book Chapter] 2006

Articles

• Bhattacharyya Sohinee, Corrigendum 2017

Publications

• Journal of Agricultural and Food Chemistry
  Voss Kenneth, Reduction of Fumonisin Toxicity by Extrusion and Nixtamalization (Alkaline Cooking)
  65:33, p. 7088 - 7096 2017
• Toxicology and Applied Pharmacology
  Gardner Nicole M., Elevated Nuclear Sphingoid Base-1-Phosphates and Decreased Histone Deacetylase Activity After Fumonisin B1 Treatment in Mouse Embryonic Fibroblasts
  298, p. 56 - 65 2016
• Scientific Reports
  Bhattacharyya S., Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development
  6, p. (23 pages) 2016
• Toxicological Sciences : An Official Journal of the Society of Toxicology
  Gardner Nicole M., Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects
  150:1, p. 161 - 168 2016
• Molecular Nutrition & Food Research
  Riley R. T., Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala
  59:11, p. 2209 - 2224 2015
• Food Additives & Contaminants. Part A. Chemistry, Analysis, Control, Exposure & Risk Assessment
  Riley R. T., A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans
  32:6, p. 934 - 949 2015
• World Mycotoxin Journal
  Torres O., Human health implications from co-exposure to aflatoxins and fumonisins in maize-based foods in Latin America: Guatemala as a case study
  8:2, p. 143 - 159 2015
• Molecular Nutrition & Food Research
  Torres Olga, Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala
  58:5, p. 973 - 983 2014
• Molecular nutrition & food research
  Voss Kenneth A, Fumonisin B, induced neural tube defects were not increased in LM/Bc mice fed folate-deficient diet
  58:6, p. 1190 - 1198 2014
• Birth Defects Research. Part A. Clinical and Molecular Teratology
  Gardner N. M., Increased Nuclear Sphingoid Base-1-Phosphates and HDAC Inhibition after Fumonisin and FTY720-Treatment: The Link between Epigenomic Modifications and Neural Tube Defects?
  97:5, p. 304 - 304 2013
• International Journal of Developmental Neuroscience
  Gelineau-van Waes Janee B., Tortillas and toxins: Gene–environment interactions in fumonisin-induced neural tube defects
  30:8, p. 636 2012
• Birth Defects Research Part A - Clinical and Molecular Teratology
  Gelineau-van Waes Janee, Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720
  94:10, p. 790 - 803 2012
• Molecular Nutrition and Food Research
  Riley Ronald T., The kinetics of urinary fumonisin B1 excretion in humans consuming maize-based diets
  56:9, p. 1445 - 1455 2012
• Birth Defects Research. Part A. Clinical and Molecular Teratology
  Gardner Nicole M., Altered Expression of Sphingolipid Metabolites and TGF beta Superfamily Genes in Fumonisin and FTY720-Treated Exencephalic Embryos
  94:5, p. 312 - 312 2012
• The FASEB journal
  Callihan Phillip, Lysophospholipid signaling in human neural progenitors
  24:S1, p. 761.3 - 761.3 2010
• Toxicological Sciences
  Voss Kenneth A., Reproductive and sphingolipid metabolic effects of fumonisin B1 and its alkaline hydrolysis product in LM/Bc mice
  112:2, p. 459 - 467 2009
• Birth Defects Research Part A - Clinical and Molecular Teratology
  Waes Janee Gelineau Van, Embryonic development in the reduced folate carrier knockout mouse is modulated by maternal folate supplementation
  82:7, p. 494 - 507 2008
• BMC Genomics
  Gelineau-Van Waes Janee, Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex
  9 2008
• Experimental Eye Research
  Gelineau-van Waes J., Altered expression of the iron transporter Nramp1 (Slc11a1) during fetal development of the retinal pigment epithelium in microphthalmia-associated transcription factor Mitfmi and Mitfvitiligo mouse mutants
  86:2, p. 419 - 433 2008
• Clinical Chemistry and Laboratory Medicine
  Taparia Shveta, Importance of folate-homocysteine homeostasis during early embryonic development
  45:12, p. 1717 - 1727 2007
• Birth Defects Research Part A - Clinical and Molecular Teratology
  Zhu Huiping, Cardiovascular abnormalities in Folr1 knockout mice and folate rescue
  79:4, p. 257 - 268 2007
• The FASEB journal
  Finnell Richard H, Embryonic Consequences of Abnormal Folate Transport: Impact on Congenital Heart Defects
  21:6, p. LB40 - LB40 2007
• Birth Defects Research Part B - Developmental and Reproductive Toxicology
  Bennett Gregory D., Failure of homocysteine to induce neural tube defects in a mouse model
  77:2, p. 89 - 94 2006
• Mycotoxin Research
  Voss K. A., Fumonisins
  22:1, p. 61 - 69 2006
• JSM Mycotoxins
  Voss K.A., Fetotoxicity and neural tube defects in CD1 mice exposed to the mycotoxin fumonisin B1
  2006:Suppl4, p. 67 - 72 2006
• Birth Defects Research Part A - Clinical and Molecular Teratology
  Gelineau-Van Waes Janee, Maternal fumonisin exposure and risk for neural tube defects
  73:7, p. 487 - 497 2005
• Nestlé Nutrition workshop series. Paediatric programme
  Rosenquist Thomas H., Nutrient effects upon embryogenesis, p. 29 - 40; discussion 40 2005
• Maikotokishin
  Voss Kenneth, Trends in fumonisin research: Recent studies on the developmental effects of fumonisins and Fusarium verticillioides
  55:2, p. 91 - 100 2005
• Journal of Nutrition
  Marasas Walter F.O., Fumonisins Disrupt Sphingolipid Metabolism, Folate Transport, and Neural Tube Development in Embryo Culture and In Vivo
  134:4, p. 711 - 716 2004
• Epidemiology
  Lammer Edward J., Maternal smoking and the risk of orofacial clefts
  15:2, p. 150 - 156 2004
• Maikotokishin
  Voss Kenneth A., Fumonisins: toxicology, emerging issues, and prospects for control and detoxification
  2003:Suppl3, p. 41 - 48 2003
• Mycopathologia
  Gelineau-Van Waes J., Role of folate in fumonisin B1-induced neural tube defects
  155:1-2 SPEC 2002
• Annual Review of Pharmacology and Toxicology
  Finnell Richard H., Molecular basis of environmentally induced birth defects
  42, p. 181 - 208 2002
• Toxicology and Applied Pharmacology
  Wlodarczyk Bogdan, Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice
  177:3, p. 238 - 246 2001
• Waes Janée Gelineau Van, Importance of model organisms in understanding the biology and genetic basis of human nonsyndromic neural tube defects 2001
• Seminars in Pediatric Neurology
  Gelineau-Van Waes Janee, Genetics of neural tube defects
  8:3, p. 160 - 164 2001
• Toxicology Letters
  Ruan Ying, Folic acid protects SWV/Fnn embryo fibroblasts against arsenic toxicity
  117:3, p. 129 - 137 2000
• Annals of the New York Academy of Sciences
  Finnell Richard H., Genetic basis of susceptibility to environmentally induced neural tube defects
  919, p. 261 - 277 2000
• Nature genetics
  Piedrahita Jorge A., Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development
  23:2, p. 228 - 232 1999
• Teratology
  Gelineau-Van Waes Janee, Phenytoin-induced alterations in craniofacial gene expression
  59:1, p. 23 - 34 1999
• Annals of the New York Academy of Sciences
  JOHNSTON C. A., Physiological Significance and Interactions between Oxytocin and Central Neuropeptide and Monoamine Neurotransmitters in the Regulation of the Preovulatory Secretion of Luteinizing Hormone
  652:1, p. 440 - 442 1992

Presentations

• PRIM&R invited speaker, IACUC Chair Networking Session 2022
• Invited Speaker: Symposium on Nongenetic Factors Causing Neural Tube Defects: "Fumonisin B1 and Fingolimod: Tortilla Toxin and Oral Therapeutic Target Sphingolipid Pathways During Neural Tube Closure. 2018
• Tortillas and Toxins: Fumonisin Exposure as a Risk Factor for NTDs Hot Topics Session on Washington State NTD Cluster, 54th Annual Meeting of the Teratology Society, Bellevue, WA 2014
• Tortillas, Toxins, and Neural Tube Defects Molecular Basis of Human Disease, University of Nebraska Medical Center 2014
• Gene-Environment Interactions in Susceptibility to Fumonisin-Induced Neural Tube Defects 8th International Conference on Neural Tube Defects, Austin, TX 2013
• Invited Seminar: NWI VA Medical Center Research Seminar Series, Omaha, NE, Dec. 7, 2012 "Tortillas, Toxins, and Neural Tube Defects" 2012
• Invited Speaker: March of Dimes Prematurity Summit, Omaha, NE, Oct. 15, 2012 "Tortillas, Toxins, and Neural Tube Defects" 2012
• Teratology Society Annual Meeting 2012
• Faculty Club at Center Stage 2012
• Neural Tube Defect Symposium, International Society for Developmental Neuroscience, Mumbai, India, "Gene-Environment Interactions in Fumonisin-Induced Neural Tube Defects: Genetic Variants and Metabolic Toxin Converge on a Bicistronic Modulator of CNS Development" 2012
• Southeastern Regional Lipid Conference 2011
• 7th International Conference on Neural Tube Defects, Austin, TX, "Gene-Environment Interactions in Fumonisin-Induced Neural Tube Defects: Genetic Variants and Metabolic Toxin Converge on a Bicistronic Modulator of CNS Development" 2011
• "Embryonic Development and Birth Defects: Gene-Nutrient-Environment Interactions: A Multifactorial Perspective" 2011
• Invited Seminar: Molecular Cell Biology Seminar Series, Creighton University, Omaha, NE, May 7, 2010 "Of Maize and Men: A Tale of Tortillas, Toxins, and Teratogens" 2011
• Guest Lecture: Environmental Health Sciences Webinar, University of Georgia, Athens, GA, April 14, 2011 "Food Safety and Pregnancy: Mycotoxins and Risk for Birth Defects" 2011
• Invited Seminar: Nebraska Wesleyan University Developmental Biology Class, Lincoln, NE, April 7, 2011 "Gestational Exposure to Fumonisin and Risk for Neural Tube Defects" 2011
• Invited Seminar: Biomedical Sciences Departmental Seminar, Creighton University, Omaha, NE, Feb. 28, 2011 "Tortillas, Toxins and Pregnancy: Deciphering the Enigma of Fumonisin and Birth Defects" 2011
• Molecular Cell Biology Seminar 2010
• Biology Seminar, Wesleyan University 2010
• Molecular Basis of Human Disease graduate lecture (UNMC) 2010
• Dept. of Environmental Health Sciences Webinar, University of Georgia 2010
• Society of Toxicology, Salt Lake City, UT 2010
• FASEB Conference: Cilia, Signaling, and Human Disease, Monterey, CA 2010
• Sphingolipid Gordon Research Conference, Ventura, CA 2010
• BRTP822 graduate lecture (UNMC) 2009
• BRTP822 graduate lecture (UNMC) 2009
• BRTP822 graduate lecture (UNMC) 2009
• Neural Tube Defect Conference, Burlington, Vermont 2009

State

• Neural Tube Defect Risk Factors: Fumonisin, Folate and (Epi)genetic Interactions

• mir-574-5p Balances the Neural Progenitor Sphingolipid-APP Axis of Good and Evil

• CerS1-Gdf1: Bicistronic Balance of Neural Stem Cell Fate

• Mouse Model of Dolutegravir-Induced Neural Tube Defects

Federal

• Mycotoxins and Birth Defects in Maize-Based Cultures: A Global Health Concern (RC4)

Other

• Developing a mouse model of endometriosis to test novel therapeutic targets

Awards

• Intramural Research Award
  Creighton University School of Medicine Distinguished Research Career Award

Consulting

• HESI Dev and Repro Tox Steering Committee
  scientific advisor
  Health & Environmental Sciences Institute
  2014 - 2014
• State Program Services Committee, Nebraska Chapter
  advisor
  March of Dimes Foundation
  2014 - 2014